EKS-ANC-00449

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00449

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	424.5	1.7E-127	39	327	289

Status

Unreviewed

Ensembl Protein

ENSACAP00000014825

UniProt Accession

H9GLX1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK3

Gene Synonyms/Alias

MAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000015056	ENSACAP00000014825	ENSACAT00000015126

Organism

Anolis carolinensis

Functional Description

Protein Length

375

Protein Sequence
(FASTA)

MSAATAAAPG GAGAVPVPGA PRLGVETVKG QVFDVGPRYT DLQYIGEGAY GMVCSSYDHV 60

NKIRAAIKKI SPFEHQTYCQ RTLREIKILL RFKHENVIGI NDILRAPTID QMRDRYIVQD 120

LMETDLYKLL KTQQLSNDHI CYFLYQILRG LKYIHSANVL HRDLKPSNLL INTTCDLKIC 180

DFGLARIADP DHDHTGFLTE YVATRWYRAP EIMLNSKGYT KSIDIWSVGC ILAEMLSNRP 240

IFPGKHYLDQ LNHILGILGS PSQDDLNCII NMKARNYLQS LPQKPKVPWN KLFPKADPKA 300

LDLLDKMLTF NPNKRITVEE SLAHPYLEQY YDPSDEPVAE EPFTFDMELD DLPKEKLKEL 360

IFEETARFQP GYQGP 375

Nucleotide Sequence
(FASTA)

ATGTCGGCAG CGACAGCAGC AGCGCCTGGT GGGGCAGGAG CCGTGCCGGT GCCCGGGGCG 60

CCGAGGCTGG GCGTGGAGAC GGTGAAAGGG CAGGTCTTCG ACGTGGGCCC GCGCTACACG 120

GACCTGCAGT ACATCGGCGA GGGCGCCTAC GGAATGGTGT GTTCTTCTTA TGACCACGTG 180

AACAAGATTC GAGCTGCCAT CAAAAAGATC AGTCCCTTCG AGCATCAAAC TTATTGCCAA 240

CGCACACTGC GCGAAATAAA AATACTACTC CGCTTTAAAC ATGAGAACGT CATCGGCATC 300

AATGACATTC TGCGTGCCCC TACTATTGAT CAGATGCGTG ATAGATACAT AGTTCAGGAT 360

TTAATGGAGA CAGATCTGTA CAAGTTGCTA AAGACCCAGC AACTCAGCAA CGACCACATC 420

TGTTACTTCC TCTACCAGAT TCTCCGAGGG CTGAAATACA TTCATTCTGC CAATGTGCTG 480

CATCGGGATC TAAAGCCCAG CAATCTTCTC ATCAATACCA CATGTGACCT GAAGATCTGT 540

GATTTTGGCT TGGCCCGAAT TGCTGATCCA GACCATGACC ACACAGGGTT CTTGACAGAA 600

TATGTTGCCA CCCGCTGGTA CCGAGCCCCT GAAATCATGC TCAATTCCAA GGGCTACACC 660

AAGTCCATTG ATATATGGTC TGTGGGCTGC ATCCTGGCAG AGATGCTGTC GAACCGACCC 720

ATCTTTCCTG GCAAGCACTA CCTGGACCAG CTCAACCATA TCCTGGGTAT TCTAGGTTCC 780

CCATCTCAGG ATGACCTGAA CTGCATCATC AATATGAAGG CTCGCAACTA TCTCCAGTCG 840

CTGCCCCAAA AGCCCAAGGT TCCGTGGAAC AAACTGTTTC CTAAGGCAGA TCCCAAAGCT 900

CTAGACCTGT TGGACAAAAT GTTGACCTTT AACCCCAACA AACGCATCAC AGTGGAGGAG 960

TCCTTGGCCC ATCCTTACCT AGAGCAGTAC TACGACCCCT CAGATGAGCC CGTTGCTGAA 1020

GAGCCATTCA CTTTTGACAT GGAGCTGGAT GACCTTCCCA AAGAGAAGCT GAAAGAACTG 1080

ATATTTGAGG AGACAGCACG CTTCCAGCCT GGCTATCAAG GTCCCTGA 1128

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v+s++d+ ++ r aikk+s pf+++t ++rtlRE+k+l ++kheN+

Q: 39    YTDLQYIGEGAYGMVCSSYDHVNKIRAAIKKIS-PFEHQTYCQRTLREIKILLRFKHENV  97

         7899****************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + +++++d Y+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs

Q: 98    IGINDILRAPT-IDQMRDRYIVQDLMETDLYKLLKTQQLSNDHICYFLYQILRGLKYIHS  156

         *********99.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++

Q: 157   ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPDHDHTgfLTEYVATRWYRAPEIMLNS  216

         ***********************************999999*******************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+++l++i + +arn

Q: 217   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQDDLNCIINMKARN  276

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y++slp+k+k ++++lfpka+++aldLl+k+L+++p+kRi+vee L+hpYl

Q: 277   YLQSLPQKPKVPWNKLFPKADPKALDLLDKMLTFNPNKRITVEESLAHPYL  327

         **************************************************7

Domain Sequence
(FASTA)

YTDLQYIGEG AYGMVCSSYD HVNKIRAAIK KISPFEHQTY CQRTLREIKI LLRFKHENVI 60

GINDILRAPT IDQMRDRYIV QDLMETDLYK LLKTQQLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLINTTCDLK ICDFGLARIA DPDHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQDDLNC IINMKARNYL 240

QSLPQKPKVP WNKLFPKADP KALDLLDKML TFNPNKRITV EESLAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013