EKS-ANC-00014
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00014
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR510.29.4E-1549881255268
StatusUnreviewed
Ensembl ProteinENSACAP00000015124
UniProt AccessionH9GM91;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSRR
Gene Synonyms/Alias INSRR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000015162ENSACAP00000015124ENSACAT00000015430
OrganismAnolis carolinensis
Functional Description
Protein Length1307
Protein Sequence
(FASTA)
LAVPLVWEIK YEELVSNLII CGRGLTTLLV CDSLDIRVDV SQLRRLENCT IIEGNLQILL 60
MFTSSSEDFQ PLSFPRLVMI TEYLLLFRVY GLESLRDLFP NLAVIRGTSL FFNYALVIFE 120
MPHLRDIGLF SLTNILNGSV RIERNQELCH ISTIDWSLLQ PLHSLEHNII LHNKPVEECA 180
DVCPGMLGVE KPCVQTQKGL TGQMEYRCWT SHNCQKVCPC KAAAACTGNG ECCNPECLGG 240
CSRARDHRAC VACRHFELNG RCLRSCPELT YQYEGWRCVT AEHCASLHKV SENPRDSSRF 300
VIHQGQCLSE CPSGYKRNDS SIFCHKCEGL CPKECKVGTK TIDSTRAARD LTGCTLVEGN 360
LIINIRRADN LISDLQGSLG LIETITGFLK IKHSFALISL SFFKNLRLIR GDSMVDGNYT 420
LYVLDNQNLQ QLWDWSRHTL FIPAGKMYFA FNPRLCLSEI YRMEEITGTK GRQNKAEINP 480
RTNGDRASCK TQTLRFVSNA TESDRIVLKW ERYQPPEYRD LLSFIVYYKE SPFQNVTEYI 540
GQDACGANSW NVVDVDLPLN NDQEPGVILQ NLKPWTQYAI FVRAITLTTA EEGRDYGAQS 600
KVVYIRTMPA VPTVPRDVIS MSNSSSHLIV RWKPPTQPNG NLTYYLVLWQ QLAEDSELFV 660
NDYCHKGLRL PTSSADTRFD MDNEGREDAE DEQCCPCQSP VGQAQLGGET VSFQKKFENF 720
LHNSIIIPRP PWKVTSINKV SHSNKWKHGS SISGKSRGNK NNMKDFRISE DKVVRERTAI 780
ASLRHFTEYR IDIHACNHAA QTVGCSAATF VFARTMPEPQ ADNIPGNMTW EPAGKNTVLL 840
RWKEPQNPNG LVLKYEIKYS RESEKVVSVV CVSRHRYAQY GGYHLALLQP GNYSAKVRAT 900
SLSGNGSWTG LIKFYILGPV EEEEAGNVYV LLILMPVVLM VGIACLAIFV FLYNKKRYGT 960
LYASVNPEYF STSNMYIPDE WEVPREKITV LRELGQGSFG MVYEGIARDI EGEGQETRVA 1020
LKTVNELATM RERIEFLKEA SVMKAFRCHH VVRLLGVVSQ GQPALVIMEL MMRGDLKSFL 1080
RSLRPEAENN PGLPPPSLKE MIQMAGEIAD GMAYLNAKKF VHRDLAARNC MVSEDFTVKI 1140
GDFGMTRDIY ETDYYRKSGK GLLPVRWMSP EALKDGLFNT HSDIWSFGVV LWEIATLAEQ 1200
PYQGMSNEQV LHFVMDNGIL EKPENCPEKL HELMTWCWQQ NPRLRPSFIQ ILESIKEDMS 1260
SSFRTHSFFY SLENKHCSSW EVLDAETDQL LVSDASVLDV PNGRPLL 1307
Nucleotide Sequence
(FASTA)
CTAGCTGTGC CCCTGGTATG GGAAATAAAG TATGAGGAAT TGGTTTCAAA TCTGATAATC 60
TGTGGAAGAG GCCTAACCAC CCTGCTAGTC TGTGACAGCT TGGATATCCG CGTGGATGTC 120
TCCCAACTTC GACGGCTGGA GAACTGCACC ATCATTGAGG GCAACTTGCA GATCCTGTTG 180
ATGTTCACCA GCAGCAGCGA GGACTTCCAG CCGCTCAGCT TCCCGCGCTT GGTCATGATC 240
ACAGAGTACC TGCTCCTCTT CCGAGTCTAC GGCCTGGAGA GCCTGCGGGA CCTTTTCCCC 300
AACCTGGCGG TCATCCGAGG CACCAGCCTC TTCTTCAACT ACGCCTTGGT CATCTTCGAG 360
ATGCCCCACT TGCGCGACAT CGGCCTCTTC AGCCTCACCA ACATCTTGAA CGGCTCCGTA 420
CGCATCGAGC GCAACCAGGA GCTCTGCCAC ATCTCCACCA TCGACTGGAG CCTCCTCCAG 480
CCCCTTCACT CCCTGGAGCA CAACATCATC CTGCACAACA AGCCCGTGGA GGAGTGTGCC 540
GACGTGTGTC CGGGCATGTT GGGTGTGGAG AAGCCCTGCG TCCAGACCCA GAAGGGCCTC 600
ACGGGGCAGA TGGAATATCG CTGCTGGACC TCCCACAACT GCCAGAAAGT GTGTCCCTGC 660
AAGGCTGCGG CCGCGTGCAC CGGCAATGGA GAGTGCTGCA ACCCAGAGTG CCTGGGTGGC 720
TGCAGCCGGG CGCGGGACCA CCGGGCCTGC GTGGCCTGCC GCCACTTCGA ACTCAACGGG 780
CGCTGCCTGC GTTCCTGCCC GGAGCTGACG TATCAGTATG AGGGCTGGCG TTGTGTGACC 840
GCTGAGCACT GCGCCAGCCT GCATAAGGTG TCCGAGAACC CCCGCGACTC CTCCCGGTTC 900
GTCATCCACC AAGGACAGTG CCTCTCCGAG TGCCCCTCCG GATACAAGAG GAACGACAGC 960
AGCATTTTCT GCCACAAGTG TGAAGGCCTC TGCCCCAAGG AGTGCAAGGT GGGCACCAAG 1020
ACCATTGACT CCACCCGGGC GGCCAGGGAC TTGACGGGCT GCACCTTGGT CGAGGGCAAT 1080
CTGATCATCA ACATCCGCCG TGCGGACAAC CTGATCTCCG ACCTTCAGGG CAGCCTGGGC 1140
CTCATTGAGA CCATCACCGG ATTCCTGAAG ATCAAGCATT CCTTCGCCCT GATCTCCCTC 1200
TCCTTCTTCA AGAACCTCCG CCTGATCCGT GGAGATTCCA TGGTGGACGG AAACTATACA 1260
CTGTATGTGC TAGACAACCA GAACCTCCAG CAGCTCTGGG ACTGGAGCCG CCACACGTTG 1320
TTCATCCCGG CCGGCAAGAT GTATTTCGCC TTCAACCCCC GGCTCTGCCT CTCCGAGATC 1380
TACCGGATGG AGGAGATCAC CGGCACGAAG GGCAGGCAGA ACAAGGCAGA GATCAACCCC 1440
CGGACCAATG GGGACAGAGC CTCCTGTAAG ACCCAAACCC TGCGCTTTGT CTCCAACGCC 1500
ACGGAATCAG ACCGCATTGT CCTCAAATGG GAACGTTATC AGCCGCCCGA GTACCGGGAC 1560
CTTCTCAGTT TCATCGTCTA CTACAAGGAG TCACCCTTCC AGAATGTGAC AGAGTATATT 1620
GGGCAAGACG CCTGTGGGGC CAACAGCTGG AACGTGGTAG ATGTGGACCT TCCTTTGAAC 1680
AACGACCAGG AGCCCGGAGT AATTCTGCAG AACCTCAAGC CATGGACCCA GTATGCCATC 1740
TTTGTGCGGG CCATCACCCT CACCACCGCT GAAGAGGGGA GGGACTATGG AGCCCAGAGC 1800
AAGGTGGTCT ACATACGCAC CATGCCTGCA GTTCCAACTG TACCGCGGGA TGTTATCTCC 1860
ATGTCCAACT CTTCGTCACA TCTGATCGTA CGGTGGAAGC CACCCACCCA GCCCAACGGC 1920
AACCTCACCT ACTATCTGGT CTTGTGGCAG CAGTTGGCAG AAGACTCAGA GCTGTTTGTC 1980
AATGACTATT GCCACAAAGG CCTCCGGCTG CCCACCAGCA GCGCAGACAC CCGCTTCGAC 2040
ATGGATAATG AAGGCCGTGA GGATGCGGAA GATGAGCAGT GCTGCCCGTG TCAGAGCCCC 2100
GTCGGGCAGG CCCAGCTGGG AGGCGAAACG GTCTCTTTCC AGAAGAAGTT TGAAAACTTC 2160
CTCCACAATT CCATCATCAT CCCCAGGCCT CCGTGGAAAG TTACATCCAT CAACAAGGTT 2220
TCTCACAGCA ATAAATGGAA ACACGGTAGC TCTATAAGTG GAAAAAGTAG GGGCAACAAA 2280
AACAATATGA AGGACTTCCG TATCTCCGAG GACAAAGTGG TGAGGGAGCG GACGGCCATC 2340
GCCAGCCTTC GCCATTTCAC TGAGTACCGC ATTGATATCC ACGCCTGCAA CCACGCTGCC 2400
CAGACTGTCG GCTGCAGTGC TGCCACCTTT GTCTTCGCCA GGACCATGCC GGAACCTCAA 2460
GCAGACAACA TTCCCGGCAA CATGACCTGG GAGCCGGCTG GCAAAAACAC TGTCCTCCTC 2520
CGCTGGAAGG AGCCCCAGAA CCCCAATGGG CTGGTTCTGA AGTACGAGAT CAAATACAGT 2580
CGGGAGAGCG AGAAGGTGGT CTCCGTTGTG TGTGTCTCCC GCCACCGCTA TGCCCAGTAT 2640
GGGGGCTATC ACCTCGCCCT CCTCCAGCCG GGAAACTACT CCGCTAAGGT GCGTGCCACA 2700
TCGCTGTCCG GGAATGGATC ATGGACTGGA CTCATCAAGT TTTACATCCT TGGGCCGGTA 2760
GAGGAAGAGG AGGCTGGGAA TGTCTATGTG CTCCTGATAC TGATGCCGGT CGTCTTGATG 2820
GTGGGGATTG CGTGCTTGGC CATCTTCGTC TTCTTGTACA ACAAGAAAAG GTACGGGACA 2880
CTGTATGCCT CCGTCAACCC GGAGTATTTC AGCACTTCCA ACATGTACAT CCCGGACGAG 2940
TGGGAAGTTC CCCGGGAGAA GATCACGGTG CTTCGGGAAC TAGGCCAGGG CTCCTTTGGC 3000
ATGGTCTACG AGGGGATCGC GAGGGACATT GAGGGAGAAG GCCAGGAGAC CCGGGTGGCA 3060
CTCAAGACGG TCAACGAGTT GGCCACCATG CGGGAGCGGA TCGAGTTCCT GAAAGAGGCC 3120
TCCGTCATGA AAGCCTTCAG GTGCCACCAC GTGGTCCGGC TCCTAGGTGT GGTTTCCCAG 3180
GGCCAGCCCG CCTTGGTCAT CATGGAGCTG ATGATGCGGG GGGACCTCAA GAGCTTTCTT 3240
CGTTCCCTCC GGCCAGAAGC CGAGAACAAT CCCGGCTTGC CTCCACCTTC GCTGAAGGAG 3300
ATGATCCAAA TGGCTGGTGA GATTGCCGAC GGCATGGCCT ACCTGAACGC CAAGAAGTTT 3360
GTCCACAGGG ACCTGGCGGC CCGCAACTGC ATGGTCTCAG AGGACTTCAC GGTGAAGATT 3420
GGAGATTTTG GGATGACCAG GGACATCTAC GAGACAGATT ATTACCGCAA GTCGGGAAAA 3480
GGTCTGCTGC CCGTCCGCTG GATGTCCCCG GAAGCTCTGA AGGATGGCCT CTTCAACACT 3540
CACTCGGACA TCTGGTCCTT TGGGGTGGTG CTGTGGGAGA TTGCGACGCT GGCCGAGCAG 3600
CCCTACCAGG GCATGTCCAA CGAGCAGGTG CTACACTTCG TCATGGACAA CGGCATCCTG 3660
GAGAAGCCGG AGAACTGCCC GGAAAAACTC CACGAGCTGA TGACGTGGTG CTGGCAGCAA 3720
AATCCCCGTC TCCGGCCCTC CTTCATCCAG ATTTTGGAGA GCATCAAGGA GGACATGAGT 3780
AGCAGCTTCC GCACCCACTC CTTTTTCTAC AGCCTGGAGA ACAAGCACTG CAGCTCCTGG 3840
GAAGTTTTGG ATGCAGAGAC AGATCAGCTG CTGGTGTCTG ATGCGTCCGT GCTGGACGTC 3900
CCCAACGGCC GCCCCCTCCT T 3921
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i++lrelGqGsfGmvyeG+a+d++ +++etrva+ktvne a++rerieflkeasvmk+f+
Q: 988   ITVLRELGQGSFGMVYEGIARDIEGEGQETRVALKTVNELATMRERIEFLKEASVMKAFR  1047
         7899********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqpalv+melm +Gdlks+lrslrpe+en+++l+pp+l+++iqma+e
Q: 1048  CHHVVRLLGVVSQGQPALVIMELMMRGDLKSFLRSLRPEAENNPGLPPPSLKEMIQMAGE  1107
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+akkfvhrdlaarncmv+ed+tvkiGdfGmtrdiyetdyyrk+gkgllpvrw
Q: 1108  IADGMAYLNAKKFVHRDLAARNCMVSEDFTVKIGDFGMTRDIYETDYYRKSGKGLLPVRW  1167
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         mspe+lkdG f+++sd+wsfGvvlwei+tlaeqpyqG+sneqvl+fv+d+g+lekpencp
Q: 1168  MSPEALKDGLFNTHSDIWSFGVVLWEIATLAEQPYQGMSNEQVLHFVMDNGILEKPENCP  1227
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         e+l+elm  cwq np+lrpsf++i+e++
Q: 1228  EKLHELMTWCWQQNPRLRPSFIQILESI  1255
         ************************9976
Domain Sequence
(FASTA)
ITVLRELGQG SFGMVYEGIA RDIEGEGQET RVALKTVNEL ATMRERIEFL KEASVMKAFR 60
CHHVVRLLGV VSQGQPALVI MELMMRGDLK SFLRSLRPEA ENNPGLPPPS LKEMIQMAGE 120
IADGMAYLNA KKFVHRDLAA RNCMVSEDFT VKIGDFGMTR DIYETDYYRK SGKGLLPVRW 180
MSPEALKDGL FNTHSDIWSF GVVLWEIATL AEQPYQGMSN EQVLHFVMDN GILEKPENCP 240
EKLHELMTWC WQQNPRLRPS FIQILESI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-BOT-00016
EKS-CAJ-00018
EKS-CAF-00018
EKS-CAP-00017
EKS-FEC-00017
EKS-GOG-00020
EKS-HOS-00019
EKS-ICT-00018
EKS-LOA-00016
EKS-MAM-00017
EKS-MOD-00016
EKS-MUM-00016
EKS-MUP-00019
EKS-NOL-00017
EKS-ORC-00016
EKS-OTG-00017
EKS-PAT-00018
EKS-PES-00018
EKS-POA-00017
EKS-RAN-00018
EKS-SAH-00015
EKS-SUS-00014
EKS-XET-00017
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013