EPS-ANC-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ANC-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	284.6	8.3E-85	23	289	267

Status

Unreviewed

Ensembl Protein

ENSACAP00000014928

UniProt Accession

H9GM06;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000015169	ENSACAP00000014928	ENSACAT00000015231

Organism

Anolis carolinensis

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPNGL DGWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT SNHDFKGRGA SPSVESVKTG IRTGFLQIDE QMRLLSEKKH 120

GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVYFF TQDHKPNNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VYEIERSEED DQFIILACDG 240

IWDVMGNEEL CEFVRSRLEV TDDLERVCNE IVDTCLYKGS RDNMSVILIC FPNAPKVLPE 300

AVKRETELDK FLESRVEEII KKQGEGVPDL VHVMRTLQTE SIPNLPPGGE LASKRSVIEA 360

VYNRLNPYRN DDTDSASTDD MW 382

Nucleotide Sequence
(FASTA)

ATGGGAGCTT TTTTAGATAA GCCAAAGATG GAGAAACACA ATGCCCAAGG GCAGGGCAAT 60

GGACTGCGTT ATGGACTAAG CAGCATGCAA GGCTGGCGTG TTGAGATGGA GGATGCACAT 120

ACAGCTGTCA TTGGCTTACC AAATGGACTT GATGGATGGT CTTTTTTTGC TGTGTATGAT 180

GGACATGCTG GATCCCAAGT TGCCAAATAC TGCTGTGAGC ATTTATTAGA TCACATCACA 240

AGCAATCATG ATTTTAAAGG GCGTGGTGCT TCACCATCCG TGGAAAGTGT AAAGACTGGA 300

ATCAGAACAG GTTTTCTGCA GATTGATGAA CAAATGAGGC TACTTTCCGA AAAGAAACAT 360

GGTGCAGATA GAAGCGGGTC AACAGCTGTG GGAGTTCTGA TTTCTCCACA GCACACATAC 420

TTTATAAACT GTGGAGACTC TAGAGGTTTG CTTTGTAGAA ACAGGAAGGT TTATTTCTTC 480

ACGCAAGATC ACAAACCAAA TAATCCACTG GAAAAGGAAC GGATACAGAA TGCAGGCGGT 540

TCAGTCATGA TTCAGCGTGT CAATGGCTCT CTGGCAGTGT CAAGAGCCCT TGGGGACTTT 600

GATTACAAAT GTGTCCATGG GAAAGGCCCG ACAGAGCAGC TTGTCTCACC TGAACCCGAA 660

GTTTATGAAA TTGAGAGATC AGAAGAAGAT GACCAGTTCA TCATACTGGC TTGTGATGGT 720

ATCTGGGATG TTATGGGAAA TGAAGAGCTG TGTGAATTTG TCAGATCAAG GCTTGAAGTC 780

ACTGACGATC TTGAAAGAGT TTGCAATGAA ATTGTTGACA CCTGCTTGTA CAAGGGAAGC 840

CGAGACAACA TGAGTGTGAT ATTGATCTGT TTTCCAAATG CACCAAAGGT ATTGCCAGAG 900

GCGGTGAAGA GAGAGACAGA GCTGGACAAG TTCCTGGAAA GCCGAGTAGA AGAGATCATA 960

AAGAAGCAGG GTGAAGGAGT GCCAGACTTA GTCCACGTCA TGCGTACTTT ACAAACAGAG 1020

AGCATCCCAA ACCTTCCACC TGGGGGTGAA TTGGCAAGCA AACGGAGTGT GATTGAAGCA 1080

GTTTATAACA GACTGAATCC TTATAGAAAT GATGATACTG ACTCTGCATC AACGGATGAT 1140

ATGTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p+  d ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPNGLDGWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************98...5555555666***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         + + +      +++ + vk+ ++++Fl++de+++ l+ek++  d+sGstav +li++++

Q: 80    TSNHDfkgrGASPSVESVKTGIRTGFLQIDEQMRLLSEKKHGADRSGSTAVGVLISPQHT  139

         ***9998887789999********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k+   ++dHkp+++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVYFFTQDHKPNNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev+++++++ed+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVYEIERSEEDDqFIILACDGIWDVMGNEELCEFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++ +++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLERVCNEIVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPNGLDG WSFFAVYDGH AGSQVAKYCC EHLLDHITSN 60

HDFKGRGASP SVESVKTGIR TGFLQIDEQM RLLSEKKHGA DRSGSTAVGV LISPQHTYFI 120

NCGDSRGLLC RNRKVYFFTQ DHKPNNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVY EIERSEEDDQ FIILACDGIW DVMGNEELCE FVRSRLEVTD 240

DLERVCNEIV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013