EKS-ANC-00186

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00186

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	396.4	5.4E-119	60	307	248

Status

Unreviewed

Ensembl Protein

ENSACAP00000014904

UniProt Accession

G1KQS2;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000015178	ENSACAP00000014904	ENSACAT00000015207

Organism

Anolis carolinensis

Functional Description

Protein Length

536

Protein Sequence
(FASTA)

MDRSKRNSIA GFPPRLERLE DFDGGGSDGT VSQMGRVWTS SYKALISAFS RLTRLDDFSC 60

EKIGSGFFSE VFKVRHKVSD QVMALKMNTL SSNRANMLKE VQLMNRLSHP NILKFMGVCV 120

HQGQLHALTE YINCGNLEQL LDGNQHLPWT VRVKLALDIA LGLCYLHFKG IFHRDLTSKN 180

CLIKHDESGY SAIVGDFGLA EKIPDFRYFI EKLPVVGSPY WMAPEVLRDE PYNEKADVFS 240

YGIILCEIIA RIQADPDFLP RTENFGLDYD AFQHMVGDCP PNFLQLAFNC CNMDPKLRPS 300

FADIVKALEE ILSNLKSEED ERERKLLILF LGLLERGQGF KRLSSLDDKI PPKSPRPRRN 360

IWLSRSQSDI FSRKPCRKIN VQDPYYTPSK GANRKVNPFN SREDLKGGKI KFFDMPSKSV 420

ISLVFDLHSP EAGTYLNIDW QESSFLPGRR SRSLPVSPEF VHKGYSTFGD LSATVSRCDP 480

SQLGAEVRQK LLSSNKYGVS EIPPFQAKHH RQVSSFLQEE EMDCSDGLQP QEENGF 536

Nucleotide Sequence
(FASTA)

ATGGATCGAA GTAAGCGAAA TTCAATTGCA GGATTTCCAC CACGCTTGGA GCGTCTTGAA 60

GACTTTGATG GTGGCGGAAG TGATGGGACT GTGTCCCAGA TGGGCAGAGT CTGGACTTCT 120

TCATACAAGG CCTTGATAAG TGCCTTTTCA AGACTTACAC GGCTTGATGA CTTTTCTTGT 180

GAGAAAATAG GATCTGGTTT CTTCTCTGAG GTATTCAAGG TGCGGCACAA GGTATCTGAT 240

CAAGTAATGG CTTTGAAGAT GAATACACTA AGTAGCAACC GTGCAAACAT GCTAAAAGAA 300

GTCCAGCTCA TGAACAGACT TTCACATCCA AACATACTAA AGTTTATGGG TGTCTGTGTA 360

CATCAAGGAC AGTTGCATGC TCTTACTGAG TATATCAACT GTGGTAACCT GGAACAATTA 420

TTAGACGGCA ATCAGCATCT TCCCTGGACA GTGAGAGTGA AACTGGCCTT GGACATTGCT 480

CTAGGACTTT GTTATCTTCA CTTTAAAGGC ATTTTCCATC GAGATTTAAC ATCTAAGAAC 540

TGTTTGATAA AGCATGATGA GAGTGGATAT TCTGCTATAG TTGGTGACTT TGGCTTGGCA 600

GAGAAAATCC CAGATTTTAG GTATTTCATT GAGAAGCTGC CAGTGGTGGG GTCTCCTTAT 660

TGGATGGCAC CTGAAGTGCT GAGAGATGAG CCATACAATG AAAAGGCGGA TGTCTTCTCA 720

TATGGGATCA TTCTTTGTGA AATTATAGCC AGGATCCAGG CCGATCCAGA CTTTCTCCCT 780

CGCACAGAGA ATTTTGGATT GGATTATGAT GCCTTTCAGC ATATGGTAGG AGATTGTCCG 840

CCGAACTTCC TCCAGTTAGC CTTCAACTGC TGCAACATGG ACCCAAAGTT ACGCCCTTCA 900

TTTGCTGACA TTGTCAAGGC ACTGGAGGAA ATCTTGAGCA ATTTGAAAAG TGAAGAGGAT 960

GAAAGAGAAA GGAAGCTTCT AATTCTTTTT TTAGGATTAC TAGAGAGAGG ACAAGGATTC 1020

AAAAGACTGA GCTCACTGGA TGACAAGATC CCACCTAAGT CTCCCCGTCC ACGGCGCAAC 1080

ATCTGGTTGT CACGCAGTCA ATCAGACATC TTCTCTCGAA AGCCTTGTCG CAAAATAAAT 1140

GTGCAGGATC CTTACTACAC ACCAAGCAAA GGAGCAAACC GCAAAGTCAA CCCCTTCAAT 1200

TCTAGGGAAG ACTTGAAAGG GGGAAAGATC AAATTTTTTG ACATGCCAAG CAAATCTGTG 1260

ATATCTCTTG TATTTGATTT GCACTCTCCA GAAGCAGGAA CGTATCTGAA CATTGACTGG 1320

CAAGAATCCT CTTTCCTTCC TGGAAGACGG AGCAGATCAC TCCCAGTCTC TCCTGAATTT 1380

GTACATAAAG GTTATAGTAC ATTTGGGGAT CTCTCAGCAA CTGTTAGTAG GTGTGATCCT 1440

AGTCAGTTAG GGGCTGAAGT GCGGCAGAAG CTACTGAGCA GCAATAAGTA TGGTGTGTCT 1500

GAGATCCCTC CTTTTCAAGC CAAACATCAT AGGCAAGTGT CTTCTTTTCT TCAAGAGGAA 1560

GAGATGGATT GCTCTGATGG ATTACAGCCT CAAGAAGAAA ATGGATTT 1608

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+h+ s +vm+lk  ++++++nr+n+lkev+l+++l+hpn+lkf+G

Q: 60    CEKIGSGFFSEVFKVRHKVSDQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILKFMG  117

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi+ G+l++ll+ +++lpwt+rv+la dia Gl ylh+kgi+hrdl+

Q: 118   VCVHQGQLHALTEYINCGNLEQLLDGNQHLPWTVRVKLALDIALGLCYLHFKGIFHRDLT  177

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s++v+dfGla          ek+++ +     ++l vvGsPywmaPe

Q: 178   SKNCLIKHdesGYSAIVGDFGLA----------EKIPDFRYF--IEKLPVVGSPYWMAPE  225

         *******9888899*********..........999998877..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPd+lPrte+fgld++af++ +v+ dcP++f

Q: 226   VLRDEPYNEKADVFSYGIILCEIIARIQADPDFLPRTENFGLDYDAFQH-MVG-DCPPNF  283

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekk  264

         l+la++cc++dp+ rpsf ++ k

Q: 284   LQLAFNCCNMDPKLRPSFADIVKA  307

         ********************9876

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHKVS DQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILKFMGVC 60

VHQGQLHALT EYINCGNLEQ LLDGNQHLPW TVRVKLALDI ALGLCYLHFK GIFHRDLTSK 120

NCLIKHDESG YSAIVGDFGL AEKIPDFRYF IEKLPVVGSP YWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDFL PRTENFGLDY DAFQHMVGDC PPNFLQLAFN CCNMDPKLRP 240

SFADIVKA 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013