EKS-ANC-00390

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00390

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	557.9	9.1E-168	570	925	356

Status

Unreviewed

Ensembl Protein

ENSACAP00000015253

UniProt Accession

G1KR75;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000015352	ENSACAP00000015253	ENSACAT00000015562

Organism

Anolis carolinensis

Functional Description

Protein Length

1053

Protein Sequence
(FASTA)

LKISPNDREV ILSLYSDFTL TCSGQNEVFW MKDSKHNIVD TVLEKKGGTF FNTLTLRNVT 60

GFDTGEYSCN YIQPPGGKAI YIFVPDPSLP FLPNTHEETF VFSTGHVEDI IPCRVTDPNT 120

TVTVYEKKVN DPVPGTYYPQ QGFKGYFDDT TYICRATIDE QEFDSEQFYI YSIEVPSLPN 180

SAINMSVSAV QTIVKRGENI SLTCTVRGIQ LVNYTWSYPG QKLGKVVKID TQFAQGIYHY 240

STLTIHNVDL EDEGSYVCEA IDTYHGGKEA QSINIRVLDH GFVTFHTVMN DTVFAELHKS 300

HVFHVQIEAY PSPTIVWSQN NQPLTSGSNN EFAISSRNLS ETRYQTTLTL VRVKQSEGGL 360

YTVRAFHEDD SKYLSFYLQI NVPAKVTDLR ENSNTSSGEQ TVTCITEGMP QPEITWFTCN 420

DVKRNRCGGE ATRILGNTSE DMNLQTNSTY RDDLRIYIVT SKLRLHRVDE PVFISCDSRN 480

LLGTDSQNIT LVPHNFPFKV IIISVILALL VLMVLFLVIL IIVWRKKPRY EIRWKVIESV 540

SSDGHEYIYV DPMQLPYDSS WEVPRDKLVL ALGRTLGSGA FGRVVEAIAH SLSHSQSTMR 600

VAVKMLKSTA RSSEKQALMS ELKIMSHLGP HLNIVNLLGA CTKGGPIYLI TEYCRYGDLV 660

DYLHRNKHTF LQCCTEKVKQ DTEVYGNAPT EDRVQSHTSL SVESDGGYMD MSKDESLDYV 720

PMSDMKGEIK YVDIDSSNYG TTYELGTYSP TVSEKVTLIN ESPILSYTDL VGVSFQVAKG 780

MDFLASKNCV HRDLAARNVL ICEGKLVKIC DFGLARDIMR DSNYISKGNT FLPLKWMAPE 840

SIFNNLYTTL SDVWSFGILL WEIFTLGGTP YPELPMNEQF YNAIKRGYRM SKPTHASNEI 900

YEIMQKCWEE KFEIRPSFSQ LVMLLGNLLT ENYRKRYQQV NEEFLKSDHP AVVRTRPRNV 960

GLNNSRSTPN SNASSSSVLY TTVEQNGLDN DYIIPLPDPK PEGVNDNPQE ASSSRASSTL 1020

NEANTSSTLS CDSPLSHQQD EEEEQEEQEL KPD 1053

Nucleotide Sequence
(FASTA)

TTGAAGATCT CTCCAAATGA CCGTGAAGTC ATCCTTAGTC TTTACAGTGA TTTTACTTTG 60

ACATGTTCTG GACAGAATGA GGTTTTCTGG ATGAAGGACA GCAAACATAA CATAGTAGAC 120

ACTGTTCTAG AGAAAAAGGG TGGCACTTTT TTTAACACCC TAACACTTAG GAACGTGACT 180

GGATTCGATA CGGGCGAGTA TTCCTGTAAT TACATCCAGC CACCTGGGGG AAAGGCCATC 240

TATATTTTTG TACCAGACCC CTCTTTGCCA TTCCTACCAA ATACACACGA AGAAACATTT 300

GTTTTTAGTA CTGGCCATGT GGAGGACATT ATCCCATGTC GTGTGACAGA CCCAAACACT 360

ACAGTGACTG TGTATGAAAA AAAGGTTAAT GACCCTGTCC CTGGCACTTA TTACCCACAA 420

CAAGGGTTTA AGGGATACTT TGATGATACA ACATACATCT GTAGAGCAAC TATAGATGAG 480

CAAGAGTTTG ACTCTGAGCA ATTCTATATC TACAGCATTG AAGTTCCTTC TCTACCTAAC 540

TCCGCTATCA ACATGTCTGT TAGTGCAGTG CAAACTATTG TGAAGCGTGG TGAAAATATA 600

TCTTTGACAT GTACAGTGAG AGGTATTCAG TTGGTTAATT ACACCTGGAG CTATCCAGGC 660

CAGAAACTAG GCAAGGTGGT TAAGATAGAT ACACAGTTTG CACAAGGGAT CTACCACTAT 720

TCCACACTAA CCATCCACAA TGTTGACCTA GAAGATGAAG GATCATATGT TTGTGAGGCC 780

ATTGATACCT ATCATGGAGG AAAAGAAGCA CAAAGCATCA ATATCAGAGT GCTTGACCAT 840

GGATTTGTGA CCTTTCACAC TGTTATGAAT GACACTGTGT TTGCTGAACT GCACAAGAGC 900

CATGTTTTCC ATGTGCAGAT CGAGGCCTAT CCAAGCCCCA CTATTGTTTG GTCTCAGAAT 960

AACCAACCAC TGACCTCAGG AAGCAACAAC GAATTTGCCA TCAGCAGCAG GAATTTGTCA 1020

GAAACCAGGT ATCAAACTAC TCTAACCCTT GTAAGAGTGA AACAGAGTGA AGGAGGTTTA 1080

TACACTGTCC GAGCTTTCCA TGAAGATGAC TCGAAGTACC TCTCTTTTTA CTTGCAGATT 1140

AATGTCCCAG CTAAAGTGAC TGACCTGAGA GAAAACAGCA ACACCAGCAG TGGGGAGCAA 1200

ACTGTGACAT GTATTACAGA AGGAATGCCT CAGCCAGAGA TTACCTGGTT TACCTGCAAT 1260

GATGTCAAGC GAAACAGGTG TGGTGGGGAG GCCACCAGAA TCCTGGGGAA TACTTCTGAA 1320

GATATGAACC TACAAACAAA CTCCACCTAC CGAGATGACC TAAGGATTTA CATTGTGACA 1380

AGCAAGCTGC GCCTTCACCG AGTAGATGAG CCAGTCTTCA TAAGCTGTGA CTCTAGAAAT 1440

CTCTTAGGCA CAGATTCTCA GAACATCACC TTGGTACCAC ACAATTTTCC CTTTAAAGTC 1500

ATCATCATCT CAGTTATCCT GGCCTTGCTG GTCCTTATGG TTCTTTTTTT GGTGATCCTC 1560

ATCATTGTGT GGCGAAAGAA ACCTCGCTAT GAAATCCGCT GGAAGGTGAT TGAGTCAGTC 1620

AGCTCTGATG GACATGAATA CATCTATGTG GACCCCATGC AGCTTCCTTA TGATTCCAGT 1680

TGGGAGGTTC CAAGGGATAA GCTTGTGCTG GCTCTAGGGC GCACGCTGGG CTCTGGAGCC 1740

TTTGGGCGTG TGGTGGAAGC CATTGCCCAC AGCCTCAGCC ATTCTCAGTC CACCATGAGG 1800

GTTGCTGTGA AAATGCTCAA GTCTACTGCA CGAAGCAGTG AGAAACAAGC ACTCATGTCA 1860

GAACTTAAAA TCATGAGTCA TCTTGGGCCT CACCTGAACA TTGTCAACCT GCTTGGTGCC 1920

TGCACAAAAG GAGGTCCCAT CTATCTCATA ACAGAATACT GCCGATATGG AGACCTGGTG 1980

GACTACCTGC ACAGGAACAA ACACACCTTC CTCCAGTGCT GCACCGAGAA AGTAAAGCAG 2040

GACACAGAGG TGTATGGGAA TGCTCCCACT GAGGACAGGG TGCAAAGCCA TACATCGTTA 2100

TCTGTGGAAA GTGACGGGGG CTACATGGAT ATGAGTAAAG ATGAATCATT GGATTATGTG 2160

CCCATGTCAG ACATGAAGGG TGAAATCAAG TATGTGGACA TTGATTCCTC CAATTATGGT 2220

ACCACTTATG AGCTGGGCAC CTATTCACCC ACAGTTTCTG AGAAAGTGAC ACTGATAAAC 2280

GAGTCTCCTA TCCTCAGCTA CACTGATCTT GTTGGCGTTA GCTTCCAAGT GGCCAAAGGG 2340

ATGGACTTCC TAGCTTCCAA AAATTGTGTG CACCGAGACC TGGCTGCAAG AAATGTTCTC 2400

ATCTGTGAAG GAAAGCTGGT GAAGATCTGT GACTTTGGCC TAGCAAGAGA TATCATGAGA 2460

GATTCAAATT ATATTTCCAA AGGAAATACC TTCTTGCCTT TGAAATGGAT GGCACCTGAA 2520

AGCATCTTCA ACAACCTGTA CACTACCTTG AGTGATGTGT GGTCTTTTGG GATCCTTCTA 2580

TGGGAAATAT TCACTCTGGG TGGGACTCCA TATCCTGAAC TGCCCATGAA TGAACAATTC 2640

TACAATGCCA TCAAGCGTGG TTACCGAATG TCTAAGCCAA CTCACGCATC TAATGAGATC 2700

TATGAAATCA TGCAGAAATG CTGGGAGGAA AAATTTGAGA TCAGACCATC ATTCTCTCAG 2760

CTAGTTATGC TCTTGGGGAA TCTGCTGACA GAAAACTATA GGAAGAGGTA TCAACAGGTT 2820

AATGAAGAAT TCTTGAAGAG CGATCACCCT GCAGTTGTGA GAACAAGGCC CAGAAATGTG 2880

GGGCTCAACA ATTCCAGGTC CACTCCCAAC TCCAATGCCA GTTCAAGCTC TGTGCTTTAC 2940

ACTACTGTGG AGCAGAATGG ACTAGACAAT GATTACATCA TTCCTTTGCC TGACCCTAAA 3000

CCTGAAGGAG TCAATGACAA CCCTCAAGAG GCCTCCAGCA GTCGGGCAAG TTCTACATTG 3060

AATGAAGCAA ATACATCATC TACTCTGTCC TGTGACAGCC CTCTATCACA TCAGCAAGAT 3120

GAAGAAGAAG AACAAGAAGA ACAAGAACTA AAGCCAGAC 3159

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l lG++lGsGafG+vvea a+ ls+s+++++vavkmlkstarssek+almselki+shlG

Q: 570   LALGRTLGSGAFGRVVEAIAHSLSHSQSTMRVAVKMLKSTARSSEKQALMSELKIMSHLG  629

         689*********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+nivnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+  +ek k +++e++  +

Q: 630   PHLNIVNLLGACTKGGPIYLITEYCRYGDLVDYLHRNKHTFLQCCTEKVK-QDTEVYG-N  687

         ******************************************99999855.4555555.4

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

          +++  ++s++sls+es++ y+d++kd                + d++ss++ ++++  +

Q: 688   APTEDRVQSHTSLSVESDGGYMDMSKDesldyvpmsdmkgeikYVDIDSSNYGTTYELGT  747

         68999************************************9999999999999999886

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          s + +e   +l++e s  l+++dl+  s+qvakGm+flaskncvhrdlaarnvl++eGk

Q: 748   YSPTVSEKV-TLINE-SPILSYTDLVGVSFQVAKGMDFLASKNCVHRDLAARNVLICEGK  805

         665555544.56666.8*******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kGn++lp+kwmapesif++lyt+ sdvws+Gillweif+

Q: 806   LVKICDFGLARDIMRDSNYISKGNTFLPLKWMAPESIFNNLYTTLSDVWSFGILLWEIFT  865

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         lG+tpyp+l+++++fy++ik+Gyrm++p++a++eiyeimqkcwe+++e rpsf+qlv+ll

Q: 866   LGGTPYPELPMNEQFYNAIKRGYRMSKPTHASNEIYEIMQKCWEEKFEIRPSFSQLVMLL  925

         *********************************************************986

Domain Sequence
(FASTA)

LALGRTLGSG AFGRVVEAIA HSLSHSQSTM RVAVKMLKST ARSSEKQALM SELKIMSHLG 60

PHLNIVNLLG ACTKGGPIYL ITEYCRYGDL VDYLHRNKHT FLQCCTEKVK QDTEVYGNAP 120

TEDRVQSHTS LSVESDGGYM DMSKDESLDY VPMSDMKGEI KYVDIDSSNY GTTYELGTYS 180

PTVSEKVTLI NESPILSYTD LVGVSFQVAK GMDFLASKNC VHRDLAARNV LICEGKLVKI 240

CDFGLARDIM RDSNYISKGN TFLPLKWMAP ESIFNNLYTT LSDVWSFGIL LWEIFTLGGT 300

PYPELPMNEQ FYNAIKRGYR MSKPTHASNE IYEIMQKCWE EKFEIRPSFS QLVMLL 356

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005019	; F:platelet-derived growth factor beta-receptor activity
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0060326	; P:cell chemotaxis
GO:0006807	; P:nitrogen compound metabolic process
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046488	; P:phosphatidylinositol metabolic process
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0038091	; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777	; P:protein autophosphorylation
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013