EKS-ANC-00455

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00455

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	374.8	2.3E-112	141	427	287

Status

Unreviewed

Ensembl Protein

ENSACAP00000015332

UniProt Accession

H9GMI3;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000015583	ENSACAP00000015332	ENSACAT00000015645

Organism

Anolis carolinensis

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MSLCSATAGA KMMAAYNGGT SAAAAGHHHH HHHHLAHLPP PHLHHHHHPQ HHLHPGSAAA 60

VHPVQQHASS AAAAAAAAAA AAAMLNPGQQ QPYFPSPAPG QAPGPAAAAP AQVQAAAAAA 120

VKAHHHQHTH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK 180

RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH 240

VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE 300

VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP 360

SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD 420

ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTNDFEPITN PKFDDTFEKN LSSVRQVKEI 480

IHQFILEQQK GSRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE 527

Nucleotide Sequence
(FASTA)

ATGTCTCTGT GTAGTGCCAC AGCCGGCGCA AAAATGATGG CGGCTTACAA TGGCGGTACA 60

TCCGCCGCCG CTGCAGGTCA CCACCACCAC CATCACCACC ACCTTGCCCA CCTCCCTCCT 120

CCTCATCTCC ATCACCACCA TCATCCCCAG CACCACTTGC ACCCAGGCTC TGCGGCTGCA 180

GTGCATCCTG TGCAGCAACA TGCTTCTTCG GCGGCTGCAG CGGCGGCGGC TGCGGCGGCA 240

GCTGCAGCCA TGTTAAATCC AGGCCAGCAG CAGCCATATT TCCCGTCACC GGCACCAGGT 300

CAGGCTCCTG GGCCAGCTGC AGCTGCCCCA GCTCAGGTAC AAGCTGCAGC AGCGGCTGCA 360

GTTAAAGCGC ATCATCATCA GCACACACAT CACCCGCAGC AGCAACTGGA TATCGAGCCA 420

GATCGGCCTA TTGGATATGG AGCCTTTGGT GTCGTCTGGT CAGTCACAGA TCCACGCGAT 480

GGAAAGAGAG TTGCACTCAA AAAGATGCCC AACGTCTTCC AAAATCTGGT CTCTTGCAAA 540

AGGGTCTTCC GCGAATTGAA GATGTTGTGT TTTTTTAAGC ATGACAATGT ACTCTCTGCT 600

CTTGACATTC TTCAGCCACC ACACATTGAC TACTTTGAAG AAATATATGT TGTTACAGAA 660

TTGATGCAGA GTGACCTTCA TAAGATTATC GTCTCTCCTC AACCACTCAG TTCAGATCAT 720

GTCAAAGTTT TTCTTTACCA GATTTTGAGA GGTCTGAAAT ACCTACATTC TGCTGGTATT 780

TTGCATCGAG ACATTAAACC AGGGAATCTG CTTGTGAACA GCAACTGTGT TCTTAAGATC 840

TGTGATTTTG GCTTGGCGCG GGTGGAAGAG TTAGACGAAT CGCGTCACAT GACTCAGGAA 900

GTCGTCACTC AGTATTACCG AGCTCCCGAA ATCCTGATGG GCAGCCGCCA CTACAGCAAT 960

GCTATTGATA TTTGGTCTGT GGGCTGTATA TTTGCTGAAT TACTAGGGCG GCGAATACTG 1020

TTTCAAGCTC AGAGTCCCAT TCAGCAGTTG GATTTGATCA CAGATCTTCT GGGAACACCG 1080

TCACTGGAAG CAATGAGGAC GGCTTGTGAA GGCGCCAAGG CACACATACT CAGGGGTCCT 1140

CATAAACAGC CATCCCTTCC TGTCCTGTAT ACATTATCAA GTCAAGCTAC ACATGAAGCC 1200

GTTCATCTCC TTTGTAGGAT GTTGGTCTTT GATCCATCCA AGCGAATATC TGCTAAGGAT 1260

GCCTTAGCTC ATCCATATCT GGACGAAGGG CGTTTGCGAT ACCACACCTG CATGTGTAAA 1320

TGTTGCTTCT CCACCTCGAC GGGACGCGTT TACACCAACG ATTTCGAACC TATCACGAAC 1380

CCCAAGTTCG ACGATACGTT TGAAAAGAAC CTCAGTTCTG TTCGGCAGGT GAAAGAAATT 1440

ATTCATCAGT TCATTTTGGA ACAGCAGAAA GGAAGCAGAG TACCGCTGTG CATCAACCCA 1500

CAATCTGCTG CTTTTAAGAG CTTTATTAGT TCCACTGTTG CCCAGCCGTC CGAGATGCCG 1560

CCGTCTCCAC TGGTCTGGGA GTAA 1584

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 141   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  200

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 201   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  259

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 260   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  319

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 320   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  378

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 379   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  427

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

acs:100560802

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013