EKS-ANC-00056

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00056

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	354.3	4.0E-106	94	385	292

Status

Unreviewed

Ensembl Protein

ENSACAP00000015558

UniProt Accession

G1KRP4;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK14

Gene Synonyms/Alias

CDK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000015785	ENSACAP00000015558	ENSACAT00000015872

Organism

Anolis carolinensis

Functional Description

Protein Length

435

Protein Sequence
(FASTA)

ICVTKMSTRN CQGMDSVIKP LDTIPEDKKV RVQRTQSTFD PFEKPNNQVK RVHSENNACI 60

NFKTSSTGKE SPKIRRHSSP SSPTSPKFGK ADSYEKLEKL GEGSYATVYK GKSKVNGKLV 120

ALKVIRLQEE EGTPFTAIRE ASLLKGLKHA NIVLLHDIIH TKETLTLVFE FVHTDLCQYM 180

DKYPGGLHPD NVKLFLFQLL RGLSYIHQRF ILHRDLKPQN LLISDTGELK LADFGLARAK 240

SIPSHTYSNE VVTLWYRPPD VLLGSTEYST CLDMWGVGCI FVEMIQGVAA FPGMKDIQDQ 300

LERIFLLSSC LRCFGTPNEE SWPGVHSLPH FKVTDRFTQY SAKNLRQAWN KLSYVNHAED 360

LASKLLQCFP KNRLSAQAAL SHEYFSDLPP RLWELTDMSS IFSVPNVRLQ AEAGESLKVF 420

GKNNIYGKGL SNNKH 435

Nucleotide Sequence
(FASTA)

ATATGTGTCA CAAAGATGTC TACACGGAAC TGCCAAGGAA TGGATTCTGT GATCAAGCCC 60

TTGGACACAA TTCCAGAAGA CAAAAAAGTC AGAGTTCAGA GGACACAAAG CACTTTTGAT 120

CCATTTGAGA AGCCAAATAA TCAAGTGAAG CGGGTACATT CAGAGAACAA TGCCTGCATT 180

AACTTCAAGA CTTCGTCTAC TGGGAAAGAA TCTCCTAAAA TCAGACGACA TTCCAGTCCT 240

AGCTCTCCAA CGAGTCCCAA ATTTGGAAAA GCAGACTCAT ACGAAAAACT GGAAAAACTA 300

GGGGAAGGTT CATATGCCAC AGTATATAAA GGCAAAAGCA AAGTAAATGG GAAGCTGGTG 360

GCATTAAAGG TGATAAGACT TCAAGAAGAG GAAGGCACAC CATTCACTGC CATCAGAGAA 420

GCTTCTCTCT TGAAAGGTCT AAAACATGCT AACATTGTGC TGCTTCATGA TATCATTCAC 480

ACAAAAGAGA CATTGACACT GGTATTTGAG TTTGTGCACA CTGATTTATG TCAGTACATG 540

GACAAGTATC CTGGAGGACT TCATCCAGAC AATGTGAAGT TATTTTTATT TCAATTGCTG 600

CGAGGACTTT CGTACATCCA CCAGCGTTTC ATTTTGCACA GGGACCTGAA ACCGCAAAAC 660

CTTCTGATCA GTGACACTGG GGAATTGAAG CTGGCAGATT TTGGACTTGC AAGAGCCAAA 720

TCTATCCCAA GTCATACATA TTCTAATGAA GTGGTTACCT TGTGGTACAG ACCTCCAGAT 780

GTCCTTTTAG GCTCAACAGA GTATTCCACC TGCCTCGATA TGTGGGGAGT TGGTTGCATC 840

TTTGTGGAAA TGATTCAAGG TGTTGCTGCT TTTCCAGGAA TGAAAGACAT TCAAGATCAG 900

CTTGAAAGAA TATTTTTGCT CTCTTCTTGT TTAAGGTGCT TTGGTACCCC AAATGAGGAG 960

TCGTGGCCTG GAGTTCATTC TCTGCCCCAT TTCAAAGTTA CAGATCGCTT TACACAGTAC 1020

AGTGCAAAAA ACCTTAGGCA AGCCTGGAAC AAGCTAAGCT ATGTGAACCA TGCAGAGGAT 1080

CTGGCCTCCA AATTACTCCA ATGTTTCCCA AAGAACAGAT TGTCAGCACA AGCAGCTCTG 1140

AGCCATGAGT ATTTCAGTGA TTTGCCCCCA CGGCTATGGG AGCTAACTGA CATGTCTTCT 1200

ATTTTTTCTG TCCCGAATGT AAGATTACAA GCAGAGGCTG GAGAAAGCTT GAAAGTGTTT 1260

GGAAAAAACA ATATTTATGG CAAGGGTTTA TCAAACAATA AGCACTGA 1308

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 94    YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  152

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfef+++dL ++++k +  +l++++vk +l+qll+gl+y+H++

Q: 153   VLLHDIIH-TKETLTLVFEFVHTDLCQYMDKYPG-GLHPDNVKLFLFQLLRGLSYIHQRF  210

         ********.99**********************9.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s p++ty++evvTlwYr+P++Llg++eYst

Q: 211   ILHRDLKPQNLLISDTGELKLADFGLARAKSIPSHTYSNEVVTLWYRPPDVLLGSTEYST  270

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerif......kllgtpsekvwpevsklpe  233

          +D+W+vgci++e+++  + f+g ++ +dqlerif      +++gtp+e++wp+v++lp+

Q: 271   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFllssclRCFGTPNEESWPGVHSLPH  330

         ************************99779****98555554678****************

S: 234   yk..ksfpkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         +k   +f+++++k+l++ ++kl+  ++a dl +kll++ pk+R+sa++al+h+yf

Q: 331   FKvtDRFTQYSAKNLRQAWNKLSyvNHAEDLASKLLQCFPKNRLSAQAALSHEYF  385

         **86699999*********99997678***************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEFVH TDLCQYMDKY PGGLHPDNVK LFLFQLLRGL SYIHQRFILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSIP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLLSSCLRC FGTPNEESWP GVHSLPHFKV 240

TDRFTQYSAK NLRQAWNKLS YVNHAEDLAS KLLQCFPKNR LSAQAALSHE YF 292

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000308	; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013