EKS-ANC-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	441.5	1.0E-132	217	485	269

Status

Unreviewed

Ensembl Protein

ENSACAP00000015732

UniProt Accession

G1KRY6;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000015906	ENSACAP00000015732	ENSACAT00000016048

Organism

Anolis carolinensis

Functional Description

Protein Length

559

Protein Sequence
(FASTA)

DIMITYFEPS ISFEGLCNEV RDMCAFDNEQ LFTMKWIDEE GDPCTVSSQL ELEEAFRLYE 60

LNKDSELLIH VFPCVPERPG MPCPGEDKSI YRRGARRWRK LYCANGHTFQ AKRFNRRAHC 120

AICTDRIWGL GRQGYKCINC KLLVHKKCHK LVSRECGRHA LPPESMDHSS VHPDNIEPVI 180

PYHPSSHESL DHVGEEKEAT SIRESGKVSS SLGLQDFDLL RVIGRGSYAK VLLVRLKKTE 240

RIYAMKVVKK ELVNDDEDID WVQTEKHVFE QASNHPFLVG LHSCFQTESR LFFVIEYVNG 300

GDLMFHMQRQ RKLPEEHSRF YSAEISLALN YLHERGIIYR DLKLDNVLLD SEGHIKLTDY 360

GMCKEGLRPG DTTSTFCGTP NYIAPEILRG EDYGFSVDWW ALGVLMFEMM AGRSPFDIVG 420

SSDNPDQNTE DYLFQVILEK QIRIPRSLSV KAASVLKSFL NKDPKERLGC HPQTGFADIQ 480

GHPFFRNVDW DLMEQKQVVP PFKPNISGEF GLDNFDSQFT NEPVQLTPDD DDIVKKIDQS 540

EFEGFEYINP LLMSAEECV 559

Nucleotide Sequence
(FASTA)

GATATTATGA TAACCTATTT TGAACCTTCC ATCTCCTTTG AGGGCCTGTG TAATGAAGTT 60

CGAGATATGT GCGCCTTTGA TAATGAGCAG CTCTTCACCA TGAAATGGAT AGATGAAGAA 120

GGGGATCCAT GTACTGTTTC TTCTCAGCTG GAATTGGAAG AGGCCTTTCG TTTATATGAA 180

CTAAATAAGG ATTCTGAACT TCTAATACAT GTGTTTCCTT GTGTACCTGA GAGGCCTGGA 240

ATGCCCTGTC CTGGGGAAGA CAAGTCTATA TATCGTCGGG GTGCGCGACG GTGGCGAAAG 300

CTCTATTGTG CAAATGGTCA TACTTTTCAA GCCAAGAGAT TTAACAGAAG AGCTCACTGT 360

GCCATTTGTA CTGACCGAAT ATGGGGATTA GGACGTCAGG GATATAAATG CATCAACTGT 420

AAACTTCTGG TTCACAAGAA GTGCCACAAA CTTGTTAGCA GAGAATGTGG CCGACACGCA 480

CTACCACCAG AGTCTATGGA TCATTCATCA GTACACCCTG ATAACATAGA ACCAGTGATT 540

CCATATCATC CTTCCAGTCA TGAAAGCTTA GATCACGTTG GTGAAGAAAA AGAGGCAACA 600

AGTATTAGAG AAAGTGGCAA AGTTTCTTCC AGTCTCGGTC TCCAAGATTT TGATCTACTT 660

CGAGTTATAG GGAGAGGAAG TTACGCAAAA GTACTTTTGG TTCGTTTAAA GAAGACAGAG 720

CGCATATATG CGATGAAAGT TGTGAAAAAA GAACTAGTCA ATGATGATGA GGATATTGAT 780

TGGGTTCAGA CAGAAAAACA TGTTTTTGAA CAGGCATCTA ATCATCCCTT CCTTGTTGGT 840

CTTCACTCCT GTTTCCAGAC AGAGAGCAGG TTATTTTTTG TCATTGAATA TGTAAATGGA 900

GGGGATCTCA TGTTTCATAT GCAGCGCCAA AGAAAATTGC CAGAAGAACA CTCTAGGTTT 960

TATTCTGCAG AAATCAGTTT AGCACTAAAC TATCTTCATG AACGAGGAAT AATTTATAGG 1020

GACCTGAAGC TAGACAATGT GTTGCTGGAT TCTGAGGGAC ATATCAAACT GACTGACTAC 1080

GGCATGTGTA AGGAAGGATT AAGGCCTGGA GATACAACCA GCACTTTCTG TGGCACTCCC 1140

AACTACATTG CTCCAGAGAT CTTACGTGGA GAAGATTATG GGTTTAGTGT GGACTGGTGG 1200

GCTTTGGGTG TGCTGATGTT TGAAATGATG GCAGGAAGAT CGCCTTTTGA TATTGTTGGA 1260

AGTTCTGATA ATCCTGATCA AAACACAGAA GACTATCTTT TCCAAGTTAT TCTGGAGAAG 1320

CAAATCCGTA TCCCACGATC CCTTTCTGTG AAGGCAGCAA GTGTTCTAAA AAGTTTTCTC 1380

AACAAGGATC CAAAAGAACG TTTAGGGTGC CATCCGCAAA CAGGATTTGC AGACATTCAG 1440

GGACATCCAT TTTTCCGTAA TGTTGATTGG GATCTGATGG AACAAAAACA AGTGGTTCCT 1500

CCATTTAAAC CAAACATATC TGGAGAATTT GGTCTGGACA ACTTTGATTC CCAGTTCACA 1560

AATGAACCTG TTCAACTCAC TCCTGATGAT GATGATATTG TGAAGAAGAT TGATCAGTCT 1620

GAATTTGAAG GTTTTGAATA CATCAATCCC CTTCTGATGT CTGCTGAGGA ATGTGTCTGA 1680

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 217   FDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  276

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee++rfy+aei+lal++lhe+g

Q: 277   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHSRFYSAEISLALNYLHERG  336

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 337   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  396

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 397   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  456

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         k++l+kdp++rlG++ ++g +di+ h+ff

Q: 457   KSFLNKDPKERLGCHpQTGFADIQGHPFF  485

         **************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HSRFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0043220	; C:Schmidt-Lanterman incisure
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0007015	; P:actin filament organization
GO:0045216	; P:cell-cell junction organization
GO:0035089	; P:establishment of apical/basal cell polarity
GO:0035556	; P:intracellular signal transduction
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:2000353	; P:positive regulation of endothelial cell apoptotic process
GO:0090004	; P:positive regulation of establishment of protein localization to plasma membrane
GO:0046326	; P:positive regulation of glucose import
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013