EKS-ANC-00054

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00054

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	365.1	2.1E-109	12	295	284

Status

Unreviewed

Ensembl Protein

ENSACAP00000016200

UniProt Accession

G1KSN0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000016452	ENSACAP00000016200	ENSACAT00000016523

Organism

Anolis carolinensis

Functional Description

Protein Length

345

Protein Sequence
(FASTA)

FGMEARARAK RYEKLDFLGE GQFATVYKAK DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDTSLVLT PSHIKAYMLM 120

TLQGLEYLHA HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRVYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRA PFLPGDSDLD QLTKIFETLG TPTEEQWPGM 240

TSLPDYVTFK SFPGMLLHHI FSAASDDLLE LLQGLFTFNP STRLTATQAL KHDYFSNRPA 300

PTPGSQLPRP NCPAEALKEQ QNVVPNLKRK RVDGIDQGLS KKLVF 345

Nucleotide Sequence
(FASTA)

TTCGGGATGG AGGCGCGGGC GCGGGCCAAG CGCTACGAGA AGCTCGACTT CCTGGGGGAA 60

GGGCAGTTCG CTACTGTGTA TAAAGCAAAA GACAAGAATA CAAACCAAAT TGTTGCTATT 120

AAAAAGATCA AACTTGGCCA TAGATCAGAA GCAAAAGATG GTATAAACAG AACAGCCCTC 180

AGAGAAATAA AACTGTTGCA GGAGCTTAGT CATCCAAATA TTATTGGGCT TCTTGATGCA 240

TTTGGACACA AATCCAACAT TAGTCTAGTG TTTGATTTTA TGGAAACAGA TTTAGAGGTT 300

ATAATAAAGG ACACTAGCCT TGTGCTGACA CCTTCACACA TCAAAGCATA CATGCTGATG 360

ACACTTCAGG GTTTAGAATA TTTACATGCG CACTGGATTC TTCATAGGGA TCTCAAGCCT 420

AACAACTTGC TGCTGGATGA AAATGGAGTT TTGAAACTGG CTGACTTTGG TTTAGCAAAA 480

TCTTTTGGAA GTCCAAATAG AGTTTATACA CATCAAGTGG TTACAAGATG GTATCGAGCT 540

CCTGAGCTAC TCTTTGGTGC TAGGATGTAT GGTGTGGGCG TGGATATGTG GGCAGTGGGC 600

TGCATATTGG CTGAACTGCT TTTAAGGGCT CCATTTTTGC CAGGAGATTC TGATCTGGAT 660

CAGCTCACAA AGATATTTGA AACTCTGGGC ACTCCCACAG AGGAACAGTG GCCTGGTATG 720

ACCAGTCTTC CAGATTATGT GACTTTTAAA AGTTTTCCTG GAATGCTGCT TCATCATATT 780

TTCAGTGCTG CTAGTGATGA TTTGCTTGAA CTACTGCAAG GCTTATTTAC ATTTAATCCT 840

TCTACCAGGT TGACTGCTAC GCAGGCACTG AAGCATGATT ATTTTAGTAA TCGACCAGCA 900

CCAACACCTG GAAGCCAGTT ACCAAGACCG AATTGTCCCG CAGAAGCCTT GAAAGAACAG 960

CAAAATGTAG TTCCAAATTT GAAAAGGAAA AGAGTGGATG GAATAGATCA AGGGTTATCG 1020

AAAAAACTGG TGTTTTGA 1038

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vykakdk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKAKDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDTSL-VLTPSHIKAYMLMTLQGLEYLH  129

         ***********.99***********************.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp++ yt++vvT+wYraPelL+ga+

Q: 130   AHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRVYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql++if++lgtp+e++wp++++lp+y  +

Q: 190   YGVGVDMWAVGCILAELLLRAPFLPGDSDLDQLTKIFETLGTPTEEQWPGMTSLPDYV-T  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ +++++++ l+ll+ l++++p++R++a++al+h+yf

Q: 249   FKSFPGMLLHHIFSAASDDLLELLQGLFTFNPSTRLTATQALKHDYF  295

         9999999******999999***************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKAKD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDTSLVLTP SHIKAYMLMT LQGLEYLHAH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRVYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRAP FLPGDSDLDQ LTKIFETLGT PTEEQWPGMT SLPDYVTFKS 240

FPGMLLHHIF SAASDDLLEL LQGLFTFNPS TRLTATQALK HDYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013