EKS-ANC-00144

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00144

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	515.3	4.0E-155	89	382	294

Status

Unreviewed

Ensembl Protein

ENSACAP00000016350

UniProt Accession

G1KSU7;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000016606	ENSACAP00000016350	ENSACAT00000016674

Organism

Anolis carolinensis

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MAMTGPAPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLRDE 60

EKRMRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLSEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240

HRTEFYRNLS HNLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LIFPPEVPIS ERAKDLILRF 360

CCEWEHRIGA PGVEEIKTNP FFEGVDWEHI RERPAAIPIE IKSIDDTSNF DEFPESDILK 420

PAVTTSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKDGK 465

Nucleotide Sequence
(FASTA)

ATGGCAATGA CCGGCCCAGC ACCTTGCTCA TCTATGAGCA ACCATACGAA GGAGCGAGTT 60

ACAATGACAA AAGTGACATT AGAAAATTTC TACAGTAATC TGATTGCACA GCATGAAGAA 120

CGGGAAATGA GACAAAAGAA GCTAGAAAAG GTGATGGAAG AAGAAGGCTT GAGAGATGAA 180

GAGAAAAGGA TGAGAAGGTC CGCACATGCC CGAAAGGAAA CGGAGTTTCT GCGCCTAAAA 240

AGGACAAGAC TTGGATTGGA AGATTTTGAG TCTTTAAAAG TAATTGGCAG AGGAGCATTT 300

GGAGAGGTAC GGCTTGTTCA GAAAAAAGAT ACAGGACACG TGTATGCAAT GAAAATTTTG 360

CGCAAAGCAG ACATGCTTGA AAAAGAGCAG GTTGGCCATA TTCGAGCAGA GCGTGACATT 420

CTAGTGGAAG CAGATAGTTT GTGGGTTGTA AAAATGTTCT ATAGCTTTCA GGATAAGCTA 480

AACCTGTATC TAATTATGGA ATTCCTACCT GGAGGAGATA TGATGACATT ATTGATGAAA 540

AAAGATACTC TGTCAGAAGA AGAGACTCAG TTTTATATAG CAGAGACTGT GCTAGCAATT 600

GATTCAATTC ACCAGCTGGG TTTTATTCAT CGTGATATCA AGCCAGATAA TCTTCTTTTG 660

GACAGTAAGG GACACGTGAA ACTGTCAGAC TTTGGTCTCT GCACTGGACT AAAGAAAGCA 720

CATAGAACAG AGTTTTATAG AAACCTGAGC CACAATCTGC CTAGTGACTT TACCTTTCAG 780

AATATGAACT CTAAAAGGAA AGCAGAAACT TGGAAAAGAA ACAGACGGCA ATTGGCTTTC 840

TCTACTGTGG GAACTCCAGA TTACATTGCT CCAGAAGTTT TCATGCAAAC AGGCTACAAT 900

AAACTTTGTG ACTGGTGGTC GCTTGGGGTC ATCATGTATG AGATGCTCAT TGGTTACCCT 960

CCCTTCTGTT CAGAGACACC CCAAGAAACA TATAAGAAGG TGATGAATTG GAAAGAGACG 1020

CTTATATTCC CTCCAGAGGT ACCAATCTCT GAACGAGCCA AAGATCTTAT TCTAAGGTTT 1080

TGCTGTGAAT GGGAACATCG AATTGGTGCT CCTGGTGTCG AGGAAATTAA AACAAATCCC 1140

TTTTTTGAGG GAGTTGACTG GGAGCATATC AGAGAGAGAC CAGCTGCAAT ACCTATAGAA 1200

ATCAAAAGTA TAGATGATAC ATCAAACTTT GATGAATTTC CAGAATCTGA TATCCTTAAA 1260

CCAGCAGTGA CCACAAGTAA CCACCCAGAG ACAGACTACA AGAATAAAGA CTGGGTCTTT 1320

ATCAATTATA CCTACAAGCG TTTTGAAGGC CTGACTGCTC GAGGCGCAAT ACCGTCCTAC 1380

ATGAAAGATG GAAAGTAG 1398

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLSEEETQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++

Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLSHNLPSDFTFQ----NMNS  264

         *************************************************555....5555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5544556*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqetykkv+nwketl fp+ev++se+akdli r+++++e+r+g+ Gv+eik++pff

Q: 325   ETPQETYKKVMNWKETLIFPPEVPISERAKDLILRFCCEWEHRIGAPGVEEIKTNPFF  382

         *********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLSEEE TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LSHNLPSDFT FQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYKKVMNWK ETLIFPPEVP ISERAKDLIL RFCCEWEHRI GAPGVEEIKT NPFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

acs:100554745

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013