EKS-ANC-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	457.8	1.3E-137	206	493	288

Status

Unreviewed

Ensembl Protein

ENSACAP00000016598

UniProt Accession

G1KT77;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000016836	ENSACAP00000016598	ENSACAT00000016924

Organism

Anolis carolinensis

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

LTVEGLRKSL LQLSFRGLSL RLLFSVPSAL RCLCSNCNEA NSTCETDGAC IVSITNVNGL 60

KHHVRACIPK GKLIPAGKPF FCLSSEDVRN THCCYLDFCN KIDLMVPSGH RKEDDETSSG 120

WGPVELVAVI AGPVFLLFVI MIIVVSVFHH HQRVYHNRQR LDMEDPSCEM CLSKDKTLQD 180

LVYDLSTSGS GSGLPLFVQR TVARTIVLQE IIGKGRFGEV WRGRWRGGDV AVKIFSSREE 240

RSWFREAEIY QTVMLRHENI LGFIAADNKD NGTWTQLWLV SDYHEHGSLF DYLNRYTVNI 300

EGMIKLALSA ASGLAHLHME IVGTQGKPGI AHRDLKSKNI LVKKNGTCAI ADLGLAVRHD 360

SVTDTIDIAP NQRVGTKRYM APEVLDETIN MKHFDSFKCA DIYALGLVYW EIARRCNSGG 420

IHEEYQLPYY DLVPSDPSIE EMRKVVCDQK LRPNIPNWWQ SYEALRVMGK MMRECWYANG 480

AARLTALRIK KTLSQLSIQE DVKI 504

Nucleotide Sequence
(FASTA)

CTTACAGTTG AAGGATTGAG AAAGAGTCTT TTACAACTAT CTTTTAGGGG TTTGTCACTG 60

AGACTTCTCT TCTCTGTCCC TTCAGCTTTA AGGTGTTTGT GCTCTAATTG CAACGAGGCG 120

AACTCGACAT GTGAAACAGA TGGTGCCTGC ATTGTCTCCA TAACAAATGT GAATGGGTTG 180

AAGCATCATG TCCGGGCCTG TATCCCTAAA GGAAAGCTGA TTCCTGCTGG AAAACCCTTT 240

TTTTGCCTGA GTTCAGAAGA TGTGCGCAAT ACACACTGCT GCTACTTAGA TTTCTGTAAT 300

AAAATTGATC TCATGGTACC CAGTGGTCAT CGAAAAGAAG ATGATGAAAC TTCTTCTGGA 360

TGGGGACCTG TGGAGCTGGT GGCTGTGATT GCAGGGCCAG TGTTCCTTTT ATTTGTCATT 420

ATGATCATTG TAGTTTCTGT CTTTCACCAT CACCAACGAG TATACCACAA TCGTCAACGT 480

TTGGACATGG AAGATCCATC TTGTGAGATG TGCCTCTCCA AGGACAAAAC CCTGCAAGAT 540

TTAGTATATG ATCTGTCTAC CTCTGGCTCT GGCTCAGGTT TGCCCCTCTT TGTCCAGCGC 600

ACTGTAGCTC GAACAATAGT TTTGCAAGAA ATCATTGGCA AAGGTCGTTT TGGGGAAGTC 660

TGGCGTGGTC GGTGGCGTGG TGGTGATGTA GCTGTGAAAA TCTTCTCTTC ACGAGAAGAG 720

CGTTCCTGGT TCAGGGAAGC AGAGATCTAC CAGACGGTTA TGTTGCGGCA CGAAAATATT 780

CTGGGGTTTA TTGCTGCAGA CAACAAAGAT AATGGCACTT GGACTCAATT GTGGTTGGTC 840

TCTGATTACC ATGAGCATGG CTCTCTATTT GATTACCTCA ACCGATATAC AGTAAACATT 900

GAGGGGATGA TTAAATTGGC TCTGTCTGCT GCCAGTGGAC TAGCACATCT GCACATGGAG 960

ATTGTTGGGA CCCAAGGAAA GCCTGGAATT GCACACCGAG ATTTGAAATC CAAGAATATA 1020

TTAGTGAAGA AAAATGGAAC TTGTGCCATT GCAGACCTAG GTCTAGCTGT CCGCCATGAC 1080

TCTGTTACTG ATACAATTGA CATTGCTCCC AATCAGAGGG TTGGAACAAA ACGTTACATG 1140

GCTCCTGAGG TTCTTGATGA AACTATAAAC ATGAAGCATT TTGATTCATT TAAATGTGCT 1200

GATATCTATG CCCTGGGCCT AGTTTACTGG GAAATTGCTC GCAGATGTAA CTCAGGAGGT 1260

ATTCATGAAG AATATCAGTT ACCATACTAT GACCTTGTGC CCTCTGACCC TTCCATCGAA 1320

GAAATGAGGA AGGTCGTATG TGATCAGAAG CTGCGGCCCA ACATTCCCAA TTGGTGGCAG 1380

AGTTATGAGG CTTTGCGTGT AATGGGGAAA ATGATGCGAG AATGCTGGTA TGCTAATGGG 1440

GCTGCACGGT TAACAGCCTT GCGCATCAAG AAAACTCTTT CACAACTCAG CATCCAAGAA 1500

GATGTGAAAA TCTAA 1515

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 206   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  265

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 266   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVNIEGMIKLALSAASGLAHLHMEIVGTQ  325

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk++tc+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 326   G--KPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHDSVTDTIDIAPNQRVGTKRYMAPE  383

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 384   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGIHEEYQLPYYDLVPSDPSIEEM  442

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 443   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  493

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVNIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GTCAIADLGL AVRHDSVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGIHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013