EKS-ANC-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	621.9	1.1E-187	465	744	280

Status

Unreviewed

Ensembl Protein

ENSACAP00000016616

UniProt Accession

G1KT86;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000016868	ENSACAP00000016616	ENSACAT00000016943

Organism

Anolis carolinensis

Functional Description

Protein Length

775

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGAGVTKGPL NSESSNQSLC SVGSLSDKEL ETPEKKQNDQ 60

RNRKRKAETF ETSQGKITPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PRRMEQPLYG VESSAAKELQ EEHSALPTLV SVMLAKQRLE GEQLAQRGTS LCFPFTSAQQ 180

GSPSSTGSGN TEHSCASQKQ ISVQHKQTQS DLTMEKISAL ENSKNSDLEK KEGRIDDLLR 240

ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFA 300

TVRHGASYTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQVPPATNEQ 360

KQRKNKTNGA ENETTPQSNE TAAVDRLPRL PFHSVLELKL TLAEYHEQEE IFKLRLGHLK 420

KEEAEIQAEL ERLERVRNLH IRELKRIHNE DNSQFKDHPT LNDRYLLLHL LGRGGFSEVY 480

KAFDLTEQRY VAVKIHQLNK NWRDEKKENY HKHACREYRI HKELDHPRIV KLYDYFSLDT 540

DSFCTVLEYC EGNDLDFYLK QHKLMTEKEA RSIIMQIVNA LKYLNEIKPP IIHYDLKPGN 600

ILLVNGTACG EIKITDFGLS KIMDDDSYNS VDGMELTSQG AGTYWYLPPE CFVVGKEPPK 660

ISNKVDVWSV GVIFYQCLYG RKPFGHNQSQ QDILQENTIL KATEVQFPPK PVVTPEAKAF 720

IRRCLAYRKE DRIDVQQLAC DPYLLPHIRK SVSTSSPAGA AIASTSGSSN NSSSN 775

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCA CGACGGCAGG AACTGTTGGA AGCCAGATTC 60

ACTGGAGCAG GTGTCACAAA GGGTCCCTTG AACAGTGAAT CTTCCAATCA GAGTTTGTGC 120

AGTGTGGGTT CTCTAAGTGA CAAGGAGTTG GAGACTCCTG AAAAAAAACA GAATGACCAG 180

CGCAACAGGA AGAGGAAAGC AGAAACCTTT GAAACTAGTC AAGGCAAAAT CACTCCAAGG 240

GGGCATAAAA TTAGTGATTA TTTTGAGTTT GCTGGGGGAA GTGGACCAGG AACAAGCCCT 300

GGAAGAAGCG TACCGCCTGT TGCACGCTCA TCACCACAGC ATTCCTTATC CAATCCCTTA 360

CCTCGGCGAA TGGAGCAGCC GCTTTATGGG GTAGAGAGCA GCGCAGCCAA GGAACTGCAG 420

GAGGAGCATT CTGCTCTGCC AACACTGGTG TCGGTGATGC TAGCGAAGCA GCGGCTAGAG 480

GGCGAGCAGC TGGCCCAGAG GGGTACAAGC CTCTGTTTTC CATTTACTTC GGCCCAGCAA 540

GGCAGCCCTT CCTCAACGGG TTCAGGGAAC ACAGAGCATT CCTGCGCCTC CCAAAAACAG 600

ATCTCCGTCC AACATAAACA GACACAGTCT GATCTTACAA TGGAGAAAAT ATCTGCACTA 660

GAAAACAGCA AAAACTCTGA TCTTGAAAAA AAAGAAGGCA GGATAGATGA CTTATTAAGA 720

GCAAACTGTG ATTTAAGGCG ACAAATAGAT GAACAACAAA AAATGCTTGA AAAATATAAA 780

GAGCGGTTGA ATAGATGTGT AACAATGAGC AAGAAGCTTC TTATAGAAAA GTCGAAGCAG 840

GAAAAGATGG CATGCCGAGA TAAGAGTATG CAGGATCGGT TGCGGCTGGG CCACTTTGCA 900

ACAGTCCGGC ATGGGGCCTC TTACACTGAA CAGTGGACAG ATGGCTATGC TTTCCAAAAC 960

CTTATTAAGC AGCAGGAAAG AATAAATTCC CAAAGGGAAG AGATAGAGAG GCAAAGAAAA 1020

ATGTTAGCAA AACGGAAGCC ACCTGCCATG GGACAGGTTC CACCAGCAAC AAACGAGCAG 1080

AAGCAGCGTA AGAACAAGAC CAATGGAGCA GAAAATGAGA CGACTCCCCA GTCAAATGAA 1140

ACTGCTGCAG TGGACAGGCT GCCCAGGCTC CCCTTCCACT CAGTTTTAGA GCTAAAGTTA 1200

ACATTAGCAG AATATCATGA ACAGGAGGAA ATCTTCAAAC TCCGCCTGGG TCATCTTAAA 1260

AAGGAAGAAG CAGAGATCCA AGCGGAACTG GAGCGGTTAG AGAGGGTTAG AAATCTGCAT 1320

ATCAGGGAAT TGAAAAGAAT ACACAATGAA GATAATTCAC AGTTTAAAGA CCACCCAACA 1380

CTAAATGACA GATATTTGTT GCTGCATCTC CTGGGCAGAG GAGGATTTAG TGAGGTATAT 1440

AAGGCATTTG ATTTAACAGA ACAGAGATAT GTAGCAGTAA AGATTCACCA GCTAAATAAA 1500

AACTGGAGGG ATGAAAAGAA AGAAAATTAC CACAAACATG CATGTAGAGA ATACAGAATC 1560

CATAAAGAGT TGGATCATCC TCGCATAGTT AAGCTATATG ACTATTTCTC GCTGGACACT 1620

GACTCGTTTT GTACAGTTCT AGAATACTGT GAGGGAAATG ATCTGGACTT CTACCTGAAA 1680

CAGCACAAAT TAATGACAGA GAAAGAAGCC CGGTCTATAA TCATGCAGAT TGTGAATGCA 1740

TTAAAATATT TAAATGAAAT CAAGCCACCC ATTATTCACT ATGATCTCAA ACCAGGTAAT 1800

ATCCTCTTGG TGAATGGTAC TGCATGTGGT GAGATTAAAA TCACTGACTT TGGCCTCTCA 1860

AAGATCATGG ATGATGACAG CTACAATTCC GTTGATGGCA TGGAGCTTAC ATCTCAAGGG 1920

GCTGGCACTT ACTGGTATTT GCCACCTGAG TGTTTTGTGG TTGGAAAAGA ACCTCCAAAG 1980

ATTTCAAATA AAGTTGACGT CTGGTCAGTG GGAGTAATCT TCTACCAGTG TCTTTATGGC 2040

AGAAAACCGT TTGGCCACAA CCAATCTCAG CAGGATATTC TGCAGGAGAA TACAATCCTT 2100

AAAGCTACAG AGGTGCAATT TCCTCCAAAG CCAGTAGTAA CTCCAGAAGC TAAGGCATTT 2160

ATCAGGCGCT GCCTGGCATA CCGAAAGGAA GATCGGATAG ATGTTCAACA ATTGGCATGT 2220

GATCCCTACT TACTTCCTCA CATCCGCAAG TCTGTATCAA CAAGCAGCCC AGCTGGGGCT 2280

GCTATCGCCT CAACCTCTGG ATCTTCTAAT AACAGCTCTT CAAACTGA 2328

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 465   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  524

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl++ekearsiimqiv+alkyl

Q: 525   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYL  584

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 585   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  644

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 645   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  704

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 705   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  744

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MTEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013