EKS-ANC-00140
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00140
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR556.48.2E-168479755277
StatusUnreviewed
Ensembl ProteinENSACAP00000016963
UniProt AccessionG1KTN6;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000017206ENSACAP00000016963ENSACAT00000017298
OrganismAnolis carolinensis
Functional Description
Protein Length819
Protein Sequence
(FASTA)
MVSWDSCCLI CLVVITMAGF SLARPSYNLV GEDTTLEPEE PPTKYQISQP EAHTVLPGET 60
LKLHCQLKDA TMITWTKDGV HLVPNNRTII SGEYLWIKDT TPRDSGLYAC TVDSETLYFI 120
TNITDVLSSG DDEDDNDGSE DFVNDNNPIK GPKWTQTDKM EKRLHAVPAA NTVKFRCPAT 180
GNPMPTMRWL KNGKEFKQEH RIGGYKVRNQ HWSLIMESVV PSDKGNYTCI VENIHGSINH 240
TYHLDVVERS PHRPILQAGL PANTSAILGG EAKFVCKVYS DAQPHIQWIK HIEKNGSKYG 300
PDGLPYLEVL KTAGVNTTDK EIEVLHIQNV TVEDAGEYTC LAGNSIGISF HSAWLTVLPA 360
PVEDRPYPTS PDYLEIAIYC VGVFLIVCMV MTVILCRMRS TTKKSDFSSQ PAVHKLTKRI 420
PLRRQVTVSA DSSSSMNSNT PLVRITTRLS SNTDAPMLAG VSEYELPEDP KWEFPRDKLT 480
LGKPLGEGCF GQVVMAEAVG IDKDRPKEAV TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG 540
KHKNIINLLG ACTQDGPLYV LVEYASKGNL REYLRARRPP GMEYSFDINR VPEEQMTFKD 600
LVSCTYQLAR GMEYLASQKC IHRDLAARNV LVTENNVMKI ADFGLARDIN NIDYYKKTTN 660
GRLPVKWMAP EALFDRVYTH QSDVWSFGVL MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM 720
DKPANCTNEL YMMMRDCWHA VPSQRPTFKQ LVEDLDRILT LTTNEEYLDL SGPLEQYSPS 780
YPDTRSSCSS GDDSVFSPDP MPYEPCLPKY QHINGSVKT 819
Nucleotide Sequence
(FASTA)
ATGGTCAGTT GGGATTCATG TTGCCTTATC TGCCTGGTGG TGATCACCAT GGCTGGATTT 60
TCACTGGCTC GGCCTTCGTA CAATTTAGTC GGTGAAGACA CCACTCTGGA ACCTGAAGAG 120
CCACCAACCA AATATCAGAT CTCTCAGCCC GAGGCACACA CTGTACTTCC AGGAGAAACT 180
CTGAAGTTGC ACTGTCAACT GAAAGATGCC ACCATGATCA CTTGGACTAA AGATGGGGTC 240
CATTTGGTGC CCAACAATAG AACAATCATC AGTGGGGAAT ACTTGTGGAT TAAAGATACT 300
ACTCCCAGAG ATTCAGGCCT TTATGCTTGT ACTGTAGACA GTGAGACTCT CTACTTCATT 360
ACCAATATTA CAGATGTTCT TTCATCTGGA GATGATGAAG ACGACAATGA TGGCTCTGAG 420
GATTTTGTGA ATGACAACAA CCCGATCAAA GGACCTAAGT GGACTCAAAC TGATAAAATG 480
GAGAAGCGTT TACATGCAGT CCCAGCAGCA AACACTGTAA AGTTCCGTTG TCCAGCTACA 540
GGAAACCCTA TGCCAACCAT GAGGTGGTTG AAAAATGGGA AGGAATTTAA GCAAGAGCAT 600
CGCATTGGCG GATACAAGGT GCGCAATCAG CACTGGAGTC TTATAATGGA GAGTGTTGTT 660
CCATCAGACA AAGGAAATTA TACCTGTATT GTGGAGAACA TACACGGGTC CATCAATCAC 720
ACATACCACC TTGATGTTGT TGAACGATCT CCACATAGGC CAATCCTACA AGCTGGCCTA 780
CCAGCAAACA CTTCTGCAAT TCTTGGGGGT GAAGCAAAGT TTGTCTGCAA AGTCTACAGT 840
GATGCCCAGC CTCACATCCA GTGGATAAAA CATATAGAAA AGAATGGAAG CAAATATGGG 900
CCAGATGGAC TGCCATATCT CGAAGTTTTA AAGACCGCCG GTGTTAACAC TACGGACAAA 960
GAGATTGAGG TTCTCCATAT ACAGAATGTA ACTGTTGAGG ATGCTGGGGA GTATACATGC 1020
TTGGCGGGTA ATTCTATTGG GATATCCTTT CACTCTGCAT GGTTGACAGT TCTGCCAGCT 1080
CCCGTAGAAG ACAGACCATA CCCAACATCC CCAGACTACC TGGAGATTGC CATTTACTGC 1140
GTAGGCGTAT TCCTTATTGT CTGCATGGTA ATGACAGTGA TCCTGTGCCG CATGAGATCT 1200
ACTACCAAGA AGTCAGACTT CAGTAGCCAG CCTGCTGTCC ACAAGCTGAC CAAGCGCATT 1260
CCTCTGCGTA GACAGGTAAC AGTGTCTGCA GACTCTAGTT CGTCCATGAA TTCCAACACA 1320
CCATTGGTGA GGATAACCAC CCGTCTCTCC TCTAATACCG ATGCTCCAAT GTTGGCAGGA 1380
GTTTCAGAGT ATGAGCTCCC AGAAGATCCC AAATGGGAGT TTCCAAGAGA TAAGCTGACT 1440
TTAGGAAAAC CACTTGGGGA AGGATGCTTT GGTCAAGTAG TCATGGCAGA AGCAGTGGGA 1500
ATTGACAAAG ACAGGCCAAA GGAAGCTGTG ACTGTAGCAG TAAAGATGTT GAAAGATGAT 1560
GCTACAGAAA AAGACCTCTC TGACCTTGTG TCTGAGATGG AGATGATGAA AATGATTGGC 1620
AAGCATAAAA ATATCATCAA TCTCCTTGGT GCCTGTACTC AAGATGGACC ACTGTATGTG 1680
CTTGTTGAAT ATGCTTCCAA AGGAAATTTG CGAGAGTACC TACGAGCGAG GCGGCCACCA 1740
GGAATGGAAT ATTCTTTCGA TATTAACCGA GTCCCTGAAG AGCAGATGAC ATTCAAAGAT 1800
TTAGTCTCAT GTACATACCA GTTAGCAAGA GGCATGGAAT ACTTAGCATC ACAAAAATGC 1860
ATCCATCGAG ATTTAGCAGC GAGGAATGTT TTGGTGACTG AAAATAATGT AATGAAAATC 1920
GCCGACTTTG GGTTGGCAAG AGACATCAAC AATATAGATT ATTATAAAAA GACTACTAAT 1980
GGTCGGCTGC CTGTAAAGTG GATGGCACCA GAAGCTCTAT TTGACAGAGT TTACACACAT 2040
CAAAGTGATG TATGGTCATT TGGTGTGCTG ATGTGGGAAA TCTTCACTTT AGGAGGGTCT 2100
CCATATCCAG GAATTCCAGT GGAAGAGCTT TTCAAGCTGC TTAAAGAAGG GCACAGGATG 2160
GACAAACCTG CCAATTGCAC CAATGAACTC TACATGATGA TGAGAGATTG TTGGCATGCA 2220
GTGCCTTCAC AGAGACCTAC TTTTAAGCAG CTTGTGGAAG ACTTAGATCG GATCCTCACC 2280
CTTACAACAA ATGAGGAGTA TCTAGACCTC AGTGGACCAC TGGAACAGTA TTCACCAAGC 2340
TATCCAGATA CAAGAAGTTC CTGTTCTTCG GGGGATGACT CTGTTTTTTC TCCAGATCCA 2400
ATGCCTTATG AACCTTGCCT TCCTAAGTAT CAACATATAA ATGGAAGTGT TAAAACATGA 2460
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkd++k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 479   LTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  538
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+e+s d ++++eeq+t+
Q: 539   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTF  598
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 599   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  658
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 659   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  718
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl
Q: 719   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  755
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDRPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMEYSFDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-BOT-00148
EKS-CAE-00120
EKS-CAJ-00155
EKS-CAF-00154
EKS-CII-00090
EKS-CIS-00182
EKS-DAR-00432
EKS-DRM-00071
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAG-00125
EKS-GAA-00175
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-LOA-00149
EKS-MAM-00147
EKS-MEG-00114
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-NOL-00141
EKS-ORN-00182
EKS-ORC-00138
EKS-ORL-00170
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-PEM-00079
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0045165; P:cell fate commitment
GO:0007267; P:cell-cell signaling
GO:0050673; P:epithelial cell proliferation
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0035265; P:organ growth
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013