EKS-ANC-00290
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00290
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR494.55.6E-149683940258
StatusUnreviewed
Ensembl ProteinENSACAP00000017185
UniProt AccessionG1KTY1;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000017406ENSACAP00000017185ENSACAT00000017522
OrganismAnolis carolinensis
Functional Description
Protein Length1183
Protein Sequence
(FASTA)
VCQGTSNRLS QLGSVEDHYN SLKRMYEDCE VVLGNLEITC LEPNYNLTFL KSIQEVAGYV 60
LIALNTVKVI PLENLQIIRG NTLYENAALT ILLNYNEIEG LEELPMRRLA AEILNGGVKI 120
VGNPYLCNIN NILWNDIIES TKGFLLNLLF FFKITTGVRL PCHPNCTSGH CWGPDLENCQ 180
ILTKIGCAEQ CSGRCKGKLP SDCCHTQCAA GCTGPKESDC LACRKFWDDA TCKESCPPLQ 240
VYNPTAYQLE DNPDGKYSFG ATCVKKCPHN YVVTDYGSCV RSCNPDSTEV EENGIRKCKK 300
CDGPCSKVCN GVGAGNLTSA LAVNGSNIDY FKNCTTISGD LIFLHVSFKG DVYTHTPPLD 360
PKKLDIFRTV KEITGFLSIQ DWPANATDLS VFENLKVIRG RTKQMGRYAL AISSLDIKQL 420
GLRSLKEISD GDVVIMRNKN LCFGNTVDWT TLFVTEKQNI KIAQNRNESS CAAARQVCDP 480
LCSPVGCWGP GPTQCYSCHH FIRQQECVKE CNVMQGEPRE FIRDSECLQC HPECLVQNST 540
KTCTGPGPDN CTKCAHLIDG PHCVKSCPAG IMGENSTLIW KYTDENSVCQ PCHPNCIRGC 600
KGPGLEGCPI GSKVPSIAAG VVGSILGLVV IALGIGLYVR RRHIVRKRTL RRLLQERELV 660
EPLTPSGEAP NQALLRILKE TELKKVKVLG SGAFGTVFKG LWIPEGEKVK IPVAIKELRE 720
ATSPKANKEI LDEAYVMASV DNPHVCRLLG ICLTSTVQLI TQLMPYGCLL DYIREHKDNI 780
GSQYLLNWCV QIAKGMNYLE ERRLVHRDLA ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY 840
HAEGGKVPIK WMALESILHR IYTHQSDVWS YGVTVWELMT FGSKPYDGIP ASEISCVLEK 900
GERLPQPPVC TIDVYMIMVK CWMIDAESRP KFRELIAEFS KMARDPQRYL VIQGDERMNL 960
PSPTDSKFYR SLMEEEDMED IVDADEYLIP HQGFFSSPSN SRTPLLSSLS ATSDNSAPVT 1020
CLDINGVHRV REDSFIQRYS SDPTRSCLDD SLDDGFLPAP EYMNQLAAKP PSVSVMQTPV 1080
YNNFSLPIEP NHVVDSNHQN PHNTALDNPE YLNTSLSPFA NTIFDSSPFL GQKDNPQINL 1140
DNPDYQQDFL PNETKSNGFP KIPTAENPEY LRVATGKSEY IQA 1183
Nucleotide Sequence
(FASTA)
GTTTGTCAAG GAACCAGCAA CAGATTATCA CAGCTTGGAA GTGTGGAAGA TCACTACAAC 60
AGCTTAAAGA GAATGTATGA AGACTGTGAA GTGGTACTTG GCAACCTAGA AATCACATGT 120
CTAGAACCAA ACTATAATCT CACTTTCTTG AAGAGCATAC AGGAGGTAGC TGGTTATGTG 180
CTCATAGCAT TAAACACAGT GAAAGTTATT CCTTTGGAGA ATCTCCAGAT AATCCGAGGA 240
AATACCCTTT ATGAAAACGC TGCTCTCACT ATTTTACTAA ATTATAATGA AATCGAGGGA 300
CTCGAAGAAC TTCCAATGAG ACGTTTAGCA GCAGAAATTC TAAATGGAGG TGTTAAAATA 360
GTTGGTAACC CTTATCTCTG CAACATTAAT AATATTCTGT GGAATGACAT TATAGAATCA 420
ACCAAAGGTT TTTTGCTTAA TTTACTATTC TTTTTTAAAA TAACTACAGG TGTTCGTCTC 480
CCATGCCATC CCAACTGTAC AAGTGGACAC TGTTGGGGTC CTGATTTAGA AAATTGCCAA 540
ATATTAACAA AGATTGGCTG TGCAGAACAG TGTTCAGGTC GATGCAAGGG GAAGTTGCCA 600
AGTGACTGTT GTCATACTCA GTGTGCAGCA GGATGTACAG GCCCTAAAGA GAGTGATTGC 660
TTGGCATGCC GCAAATTTTG GGATGATGCA ACCTGTAAGG AATCTTGCCC CCCTTTGCAA 720
GTGTATAATC CTACAGCCTA TCAGTTGGAA GACAACCCAG ATGGAAAGTA CAGCTTTGGA 780
GCCACTTGTG TGAAAAAGTG TCCACATAAC TATGTTGTAA CAGACTACGG CTCATGTGTC 840
CGATCATGTA ATCCAGACTC CACTGAGGTG GAGGAAAATG GAATTAGAAA GTGTAAAAAA 900
TGTGATGGGC CATGTAGCAA GGTGTGCAAT GGAGTTGGAG CAGGTAATCT TACAAGTGCT 960
CTTGCTGTGA ATGGATCCAA CATTGACTAT TTCAAAAACT GTACCACAAT CAGTGGGGAT 1020
CTCATATTCC TTCACGTATC ATTTAAAGGT GATGTATATA CACATACTCC TCCTTTAGAC 1080
CCAAAGAAAT TGGATATTTT TCGAACAGTT AAAGAAATAA CAGGGTTTTT GTCAATCCAG 1140
GATTGGCCAG CAAATGCCAC TGACTTGAGT GTTTTTGAAA ATCTAAAAGT TATACGAGGC 1200
AGAACAAAAC AAATGGGCCG GTATGCTCTT GCTATCAGTT CCTTAGATAT AAAACAATTG 1260
GGTTTGCGGT CTCTCAAGGA AATAAGCGAT GGAGATGTTG TCATTATGAG AAACAAGAAC 1320
CTATGCTTTG GTAATACAGT AGACTGGACT ACACTTTTTG TGACAGAAAA ACAGAATATA 1380
AAAATTGCCC AGAACAGAAA TGAAAGTTCA TGTGCTGCTG CAAGGCAGGT TTGTGATCCA 1440
CTCTGCTCAC CTGTGGGCTG CTGGGGCCCA GGTCCCACCC AATGCTATTC TTGCCATCAC 1500
TTCATTCGTC AGCAGGAGTG TGTAAAGGAA TGCAATGTAA TGCAGGGGGA ACCTCGGGAA 1560
TTTATAAGAG ATTCTGAATG CCTTCAATGC CATCCAGAAT GCCTGGTGCA AAATTCAACT 1620
AAAACTTGCA CAGGACCTGG TCCAGACAAC TGCACCAAAT GTGCCCATTT AATAGACGGC 1680
CCTCACTGTG TTAAATCATG CCCTGCTGGG ATCATGGGTG AAAATAGTAC TTTAATCTGG 1740
AAATATACAG ATGAAAATTC AGTGTGCCAG CCATGTCATC CAAATTGTAT TCGTGGATGC 1800
AAAGGACCAG GACTTGAAGG TTGTCCTATT GGCTCGAAGG TCCCATCAAT TGCTGCTGGA 1860
GTTGTTGGAA GTATTCTTGG CTTAGTTGTT ATAGCATTGG GCATTGGTCT CTATGTACGC 1920
AGGCGTCACA TTGTTCGGAA ACGTACTTTG CGCAGGCTGC TACAAGAAAG AGAGCTTGTT 1980
GAGCCCCTGA CTCCCAGTGG TGAGGCACCA AACCAAGCAC TCCTAAGAAT TCTAAAGGAA 2040
ACGGAATTAA AAAAAGTCAA GGTTCTTGGT TCTGGCGCTT TTGGTACTGT CTTTAAGGGA 2100
CTGTGGATTC CAGAAGGGGA GAAGGTTAAA ATTCCTGTGG CCATTAAGGA ATTGAGAGAA 2160
GCCACGTCCC CCAAAGCCAA CAAAGAAATT CTTGATGAAG CCTATGTAAT GGCAAGCGTA 2220
GACAACCCCC ATGTGTGCCG TTTGCTGGGA ATTTGCCTCA CATCTACAGT CCAGCTCATC 2280
ACACAACTTA TGCCATATGG GTGTCTTCTT GATTATATCC GAGAGCACAA GGATAACATT 2340
GGATCCCAAT ACCTTCTCAA TTGGTGTGTG CAGATTGCAA AGGGAATGAA TTATTTGGAA 2400
GAACGTCGTT TAGTACATCG TGATTTGGCT GCCAGGAATG TTCTAGTTAA GACTCCTCAA 2460
CATGTAAAGA TTACTGACTT TGGACTGGCA AAATTGCTTG GCGCAGAAGA AAAGGAGTAC 2520
CATGCAGAAG GAGGAAAAGT TCCTATTAAG TGGATGGCTT TGGAGTCTAT TCTGCACCGC 2580
ATATATACCC ATCAAAGTGA TGTTTGGAGT TATGGTGTCA CTGTCTGGGA ATTAATGACA 2640
TTTGGATCAA AACCATATGA TGGCATCCCG GCCAGTGAAA TTTCCTGTGT CCTGGAAAAG 2700
GGGGAGAGGT TGCCCCAGCC TCCAGTTTGT ACAATTGATG TCTACATGAT CATGGTCAAA 2760
TGTTGGATGA TTGATGCAGA GAGTCGTCCC AAATTTCGGG AACTGATAGC AGAATTCTCC 2820
AAAATGGCTC GGGACCCACA GCGCTATCTG GTTATACAGG GAGATGAAAG AATGAACCTA 2880
CCAAGCCCAA CAGACTCAAA ATTTTACCGT AGCCTCATGG AAGAAGAGGA CATGGAAGAC 2940
ATTGTGGATG CAGATGAATA CCTTATTCCA CACCAAGGAT TTTTCAGCAG CCCATCAAAT 3000
TCCCGGACAC CTCTCCTAAG TTCACTGAGT GCTACTAGTG ATAATTCTGC ACCTGTAACC 3060
TGCTTGGATA TTAATGGGGT ACATCGAGTG AGAGAAGACA GCTTTATCCA GCGATATAGT 3120
TCAGACCCAA CTAGAAGTTG CCTGGATGAC AGTCTGGATG ATGGTTTTCT ACCTGCTCCA 3180
GAATACATGA ACCAACTGGC AGCCAAACCC CCATCTGTTT CTGTCATGCA AACCCCAGTC 3240
TACAACAATT TCTCCCTTCC AATTGAGCCC AACCATGTGG TTGATTCAAA CCATCAGAAT 3300
CCGCACAACA CAGCACTGGA TAATCCAGAA TATCTCAACA CAAGCCTCTC TCCTTTTGCT 3360
AATACAATTT TTGACAGCTC CCCCTTTTTG GGCCAGAAAG ACAACCCCCA AATCAATCTG 3420
GATAATCCGG ATTATCAGCA AGATTTCTTG CCCAATGAGA CCAAATCTAA TGGCTTCCCT 3480
AAGATTCCTA CAGCCGAGAA TCCAGAATAC CTACGGGTAG CAACAGGAAA AAGTGAATAC 3540
ATTCAAGCC 3549
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkk+kvlGsGafGtv+kG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 683   LKKVKVLGSGAFGTVFKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  742
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldy+rehkd++Gsq+llnwcvqiakGm+ylee+
Q: 743   PHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER  802
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y
Q: 803   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  862
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+ +lekGerl+qpp+ctidvym++vkcw
Q: 863   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISCVLEKGERLPQPPVCTIDVYMIMVKCW  922
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         midaesrpkf+el++efs
Q: 923   MIDAESRPKFRELIAEFS  940
         ****************96
Domain Sequence
(FASTA)
LKKVKVLGSG AFGTVFKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY IREHKDNIGS QYLLNWCVQI AKGMNYLEER 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISCVLEKGE RLPQPPVCTI DVYMIMVKCW 240
MIDAESRPKF RELIAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CIS-00072
EKS-EQC-00289
EKS-FEC-00283
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORN-00388
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-PEM-00164
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0030139; C:endocytic vesicle
GO:0005768; C:endosome
GO:0045121; C:membrane raft
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005006; F:epidermal growth factor-activated receptor activity
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0008283; P:cell proliferation
GO:0016337; P:cell-cell adhesion
GO:0043066; P:negative regulation of apoptotic process
GO:0042177; P:negative regulation of protein catabolic process
GO:0035413; P:positive regulation of catenin import into nucleus
GO:0030335; P:positive regulation of cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0045739; P:positive regulation of DNA repair
GO:0045740; P:positive regulation of DNA replication
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0046777; P:protein autophosphorylation
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0070141; P:response to UV-A
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013