EKS-ANC-00215

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00215

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	393.6	3.9E-118	29	294	266

Status

Unreviewed

Ensembl Protein

ENSACAP00000017195

UniProt Accession

G1KTZ0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000017457	ENSACAP00000017195	ENSACAT00000017532

Organism

Anolis carolinensis

Functional Description

Protein Length

326

Protein Sequence
(FASTA)

ERLRTHSIES SGKLKISPEQ HWDFTAEDLK DLGEIGRGAY GSVNKMVHKP SGQIMAVKRI 60

RSTVDEKEQK QLLMDLDVVM RSSDCPYIVQ FYGALFREGD CWICMELMST SFDKFYKYVY 120

SVLDDIIPEE ILGKITLATV KALNHLKENL KIIHRDIKPS NILLDRNGNI KLCDFGISGQ 180

LVDSIAKTRD AGCRPYMAPE RIDPSASRQG YDVRSDVWSL GITLYELATG RFPYPKWNSV 240

FDQLTQVVKG DPPQLSNSDE REFSHSFINF VNLCLTKDES KRPKYKELLK HPFILMYEER 300

TVDVACYVCK ILDQMPATPS SPMYVD 326

Nucleotide Sequence
(FASTA)

GAAAGACTGA GAACACACAG CATTGAATCA TCGGGAAAGT TGAAGATTTC CCCTGAACAG 60

CATTGGGACT TTACGGCAGA GGACCTGAAA GACCTTGGAG AAATTGGACG AGGAGCTTAT 120

GGTTCTGTCA ACAAAATGGT CCACAAACCA AGTGGACAAA TTATGGCTGT TAAAAGAATT 180

CGGTCAACAG TGGATGAAAA GGAACAGAAA CAGCTTTTAA TGGATCTGGA CGTAGTTATG 240

CGAAGCAGTG ACTGCCCATA TATTGTTCAG TTTTATGGAG CACTATTCAG AGAGGGTGAC 300

TGTTGGATCT GTATGGAGCT CATGTCTACC TCGTTTGATA AATTTTACAA ATATGTATAT 360

AGTGTATTAG ATGACATTAT TCCAGAAGAA ATTCTAGGCA AAATCACTTT AGCTACTGTG 420

AAAGCACTAA ACCACTTAAA AGAAAACTTG AAAATCATTC ACAGAGATAT TAAACCTTCC 480

AATATTCTTC TGGACAGAAA TGGAAATATT AAACTCTGTG ATTTCGGCAT CAGCGGACAA 540

CTTGTAGACT CTATTGCCAA AACCAGAGAT GCAGGGTGTC GGCCGTACAT GGCACCAGAA 600

AGGATAGACC CCAGTGCATC CAGGCAAGGT TACGATGTCC GCTCCGATGT CTGGAGCTTA 660

GGGATTACAT TGTATGAGCT GGCCACCGGA CGGTTCCCCT ATCCCAAATG GAATAGTGTA 720

TTTGATCAAC TGACACAAGT AGTCAAAGGA GACCCACCTC AGCTGAGTAA TTCAGATGAA 780

CGGGAGTTCT CCCACAGTTT TATAAACTTT GTCAACTTGT GCCTTACAAA GGACGAGTCC 840

AAACGGCCAA AGTATAAGGA GCTTCTGAAA CATCCCTTCA TTCTAATGTA TGAGGAGCGA 900

ACGGTAGATG TTGCGTGCTA TGTTTGTAAA ATCCTGGATC AAATGCCAGC AACTCCCAGC 960

TCTCCCATGT ATGTTGATTG A 981

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 29    LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  88

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ +++ipe++lgki++a+vkal++lk

Q: 89    VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDIIPEEILGKITLATVKALNHLK  147

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 148   ENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  207

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 208   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSderEFSHSF  267

         9***********************************************988888******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 268   INFVNLCLTKDESKRPKYKELLKHPFI  294

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDIIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRNG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS DEREFSHSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013