EKS-ANC-00233

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00233

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	363.6	4.3E-109	26	277	252

Status

Unreviewed

Ensembl Protein

ENSACAP00000017572

UniProt Accession

G1KUE9;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK1

Gene Synonyms/Alias

SIK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000017841	ENSACAP00000017572	ENSACAT00000017918

Organism

Anolis carolinensis

Functional Description

Protein Length

802

Protein Sequence
(FASTA)

MVIMSDYTPV PTSNQSQQRP LRVGFYDIER TLGKGNFAVV KLARHRVTKT QVAIKIIDKT 60

RLDPSNLEKI YREVQIMKLL NHPHIIKLYQ VMETKDMLYI VTEFAKNGEM FDHLTSHGHL 120

SESEARKKFW QILSAVEYCH SHHIVHRDLK TENLLLDANM NIKLADFGFG NFYKSGEPLS 180

TWCGSPPYAA PEVFEGKEYE GPHLDIWSLG VVLYVLVCGS LPFDGPNLPS LRQRVLEGRF 240

RIPYFMSQDC ETLIRRMLVV DPTKRITIAQ IKQHKWILAD PSLQQHQSLS FSMHSYNSNL 300

GDYNEQVLGI MHTLGIDRQR TVESLQNSSY NHFAAIYYLL LERLKEYRSN QLANRPVSSR 360

QQRPRSSDFS NIELPQDSLA GETLRSSLMY QQPQNLIQSH LQAEMDCDMN NPLQPVFFPV 420

DPNFNSLFRN RSISPNSLLE TTISEEVRQD KELEDEIKAF NPIRLPINTS RRHTLAEVTT 480

HFYQCSPPCI VISSSTNGTE GTSSDSCLTS SANDGSVTLS NCLEEQMMLG HPATTRVTSS 540

FLASHSDTPV LQAQGCLGGA SLLPVSFQEG RRASDTSLTQ GLKAFRQQLR KNARAKGFLG 600

LNKIKGLARQ VCQSSSARLA RNSMGLFQHP QQNACLYGSS GNSGGSGSSS GSSRESRNLL 660

EEVLQQQRIL QLQHKQPACP QPSQVSQPHI IPLSDTAGSK ASNSLLLTEL QSENSLELAF 720

HNTQFLQPHL FGVGVSPVNS TAHLLDTRLH ISNNVSPIAS MFSQQNGFAL QSQSYNAVAL 780

QHGDCEMEDL TSTQMGKFVL VK 802

Nucleotide Sequence
(FASTA)

ATGGTGATCA TGTCGGATTA TACACCGGTC CCCACCTCAA ACCAGAGCCA GCAAAGGCCT 60

CTTCGAGTTG GATTCTATGA TATCGAGAGG ACCTTAGGAA AAGGCAATTT TGCCGTGGTG 120

AAGCTGGCTA GACACAGAGT CACCAAAACA CAGGTGGCAA TAAAAATAAT AGACAAAACA 180

CGGTTAGATC CAAGCAATCT GGAGAAAATC TATAGAGAGG TTCAGATAAT GAAGCTTTTG 240

AACCACCCTC ATATTATCAA GCTGTATCAG GTTATGGAAA CAAAAGATAT GCTTTACATT 300

GTGACTGAAT TCGCAAAAAA TGGAGAAATG TTTGATCATT TGACATCCCA TGGGCACCTG 360

AGTGAGAGTG AAGCTCGGAA GAAATTCTGG CAGATCCTAT CAGCTGTCGA ATATTGCCAT 420

AGCCACCACA TAGTGCACAG AGACCTCAAA ACGGAGAACC TTCTGTTAGA TGCCAACATG 480

AACATCAAGC TTGCAGACTT TGGGTTTGGA AACTTCTACA AATCTGGTGA GCCTCTCTCC 540

ACCTGGTGCG GAAGTCCCCC GTATGCAGCT CCAGAAGTTT TTGAAGGAAA AGAATATGAA 600

GGCCCTCACC TTGACATATG GAGCCTTGGT GTGGTACTAT ATGTTCTTGT CTGTGGCTCT 660

CTACCATTTG ATGGACCTAA CTTGCCATCT TTAAGGCAAA GGGTTCTTGA AGGACGATTT 720

CGCATCCCCT ACTTCATGTC CCAAGATTGT GAAACACTCA TCCGACGAAT GCTGGTTGTG 780

GATCCCACCA AACGAATCAC CATTGCCCAA ATAAAGCAGC ACAAGTGGAT CCTCGCAGAC 840

CCTTCTCTGC AGCAGCACCA GTCTTTGTCA TTTTCCATGC ACAGTTACAA CTCTAACCTG 900

GGAGACTACA ACGAGCAGGT CCTTGGGATC ATGCATACTC TTGGCATCGA CCGGCAGAGG 960

ACGGTTGAGT CTCTACAGAA TAGCAGCTAC AACCATTTTG CTGCCATCTA TTATCTTCTC 1020

TTGGAGCGGC TCAAGGAGTA TCGAAGCAAT CAGTTGGCAA ACCGGCCAGT GAGCAGCCGT 1080

CAGCAAAGGC CAAGGAGCTC AGATTTCAGC AACATTGAGT TACCTCAAGA CAGCCTTGCC 1140

GGTGAGACTT TGAGGTCATC TCTGATGTAC CAGCAGCCTC AGAATCTGAT TCAATCACAT 1200

TTGCAGGCAG AAATGGATTG TGACATGAAC AACCCTTTAC AGCCTGTGTT CTTTCCTGTG 1260

GATCCGAACT TCAACAGTCT TTTTAGGAAT CGCTCAATCT CTCCAAACAG CCTCCTGGAA 1320

ACTACCATCA GTGAAGAAGT TCGGCAGGAC AAAGAACTGG AGGATGAGAT TAAAGCCTTC 1380

AACCCCATTC GCCTCCCCAT CAACACAAGT CGAAGGCACA CATTGGCTGA AGTCACCACT 1440

CATTTTTATC AGTGCTCCCC ACCATGTATA GTCATTTCCT CTTCCACGAA TGGTACAGAA 1500

GGAACCAGTT CTGACAGCTG CCTCACTTCC TCAGCCAATG ATGGCTCTGT GACTCTGAGC 1560

AACTGTTTGG AAGAGCAGAT GATGCTTGGC CACCCAGCCA CAACCAGGGT TACGTCATCA 1620

TTCCTGGCTT CCCATTCAGA CACACCAGTG TTGCAGGCTC AGGGCTGCCT GGGAGGTGCT 1680

TCGCTGTTAC CTGTCAGCTT CCAGGAAGGA AGGAGAGCAT CCGATACCTC ATTAACACAA 1740

GGTTTGAAGG CATTTAGGCA GCAGCTGCGG AAGAATGCAA GAGCCAAGGG TTTTCTGGGA 1800

CTGAATAAAA TCAAAGGGCT CGCCCGCCAG GTGTGCCAGT CCTCATCTGC TCGACTAGCA 1860

CGGAATAGCA TGGGCCTCTT CCAACATCCT CAGCAGAATG CCTGCCTGTA TGGCAGCAGT 1920

GGAAACAGTG GCGGAAGTGG CAGCAGCAGT GGCAGCAGCA GAGAGAGCAG GAACTTGCTT 1980

GAAGAGGTTC TCCAGCAACA AAGAATTCTC CAGTTACAGC ACAAGCAGCC GGCCTGTCCT 2040

CAGCCTTCTC AGGTGTCTCA GCCGCACATC ATCCCCTTGT CTGACACTGC AGGCAGCAAA 2100

GCATCCAATT CTCTCCTCCT GACCGAACTG CAAAGTGAGA ACTCTTTAGA GCTGGCCTTT 2160

CATAACACTC AGTTTCTCCA GCCTCACCTT TTTGGGGTCG GTGTCTCTCC AGTAAATTCT 2220

ACTGCTCATC TTCTGGACAC CCGCCTGCAC ATCAGCAACA ACGTTTCTCC CATCGCCTCC 2280

ATGTTTTCTC AGCAGAACGG CTTCGCCCTG CAGTCCCAGA GCTATAATGC AGTTGCTTTG 2340

CAGCATGGAG ACTGTGAAAT GGAGGACCTT ACTTCTACCC AGATGGGGAA ATTTGTCCTG 2400

GTGAAATGA 2409

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l+ ++leki+rE++i+k l+hp+i

Q: 26    YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNLEKIYREVQIMKLLNHPHI  85

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++ly+v+e+a++ge+fd+++++g+l+e+eark f q++sav+Y+hs++iv

Q: 86    IKLYQVMETKDMLYIVTEFAKNGEMFDHLTSHGHLSESEARKKFWQILSAVEYCHSHHIV  145

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nik+aDFG++n++k+g+ l+t+cGsppYaaPe+++gk+Yegp++D

Q: 146   HRDLKTENLLLDANMNIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPHLD  205

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGvvLy+lv+g+lPfd++nl +l++++l+g+++ip+ +s+++e+L+r++Lvvdp+kR

Q: 206   IWSLGVVLYVLVCGSLPFDGPNLPSLRQRVLEGRFRIPYFMSQDCETLIRRMLVVDPTKR  265

         ************************************************************

S: 241   atieeilkhewl  252

         +ti +i++h+w+

Q: 266   ITIAQIKQHKWI  277

         ***********7

Domain Sequence
(FASTA)

YDIERTLGKG NFAVVKLARH RVTKTQVAIK IIDKTRLDPS NLEKIYREVQ IMKLLNHPHI 60

IKLYQVMETK DMLYIVTEFA KNGEMFDHLT SHGHLSESEA RKKFWQILSA VEYCHSHHIV 120

HRDLKTENLL LDANMNIKLA DFGFGNFYKS GEPLSTWCGS PPYAAPEVFE GKEYEGPHLD 180

IWSLGVVLYV LVCGSLPFDG PNLPSLRQRV LEGRFRIPYF MSQDCETLIR RMLVVDPTKR 240

ITIAQIKQHK WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0008140	; F:cAMP response element binding protein binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0072333	; P:anoikis by p53 class mediator
GO:0007243	; P:intracellular protein kinase cascade
GO:0032792	; P:negative regulation of CREB transcription factor activity
GO:0045721	; P:negative regulation of gluconeogenesis
GO:0010868	; P:negative regulation of triglyceride biosynthetic process
GO:0046777	; P:protein autophosphorylation
GO:0007346	; P:regulation of mitotic cell cycle
GO:0010830	; P:regulation of myotube differentiation

KEGG

acs:100555063

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013