EKS-ANC-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	523.3	9.6E-158	474	753	280

Status

Unreviewed

Ensembl Protein

ENSACAP00000017732

UniProt Accession

H9GPZ1;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000018003	ENSACAP00000017732	ENSACAT00000018080

Organism

Anolis carolinensis

Functional Description

Protein Length

821

Protein Sequence
(FASTA)

MPARRCLHAA RVNASAIVHS CLAFPLPPSL SLFSPLTLPV LPKTSIEVES LSAHPGDPLQ 60

LRCRLRDDVQ SINWVRDGVQ LAENNRTRIT GEEVEVRDAV PEDSGLYACM TNSPSGSETT 120

YFSVNVSDAL PSAEDDDDDD DSSSEEKEAD NSKPNRMVTP VWLCCPCRVQ SRMRSTGADK 180

TLGPTLRWRS KEDTVILSMH AFLVRHATWS IIMESVVPSD KGNYTCIVEN KYGTINHTYQ 240

LDVVERSPHR PILQAGLPAN KTVSLGSNVE FVCKVYSDPQ PHIQWLKHIE VNGSRIGPNN 300

LPYVQVLKTA GVNTTDKEME VLHLRNVSFE DAGQYTCLAG NSIGISHHSA WLTVLEAMED 360

KPAMMTSPLY LEIIIYCTGG FLISCMIVTV LLYKMKSTTK KTDFNSQLAV HKLAKSIPLR 420

RQVTVSADSS SSMNSGVMLM RPSRLSSSGT PMLAGVSEYD LPEDPRWELP RDRLILGKPL 480

GEGCFGQVVL AEAIGLDKDK PNRVTKVAVK MLKSDATEKD LSDLISEMEM MKMIGKHKNI 540

INLLGACTQD GPLYVIVEYA SKGNLREYLQ ARRPPGMEYC YNPTHLPDEQ LSFKDLVSCA 600

YQVARGMEYL ASKKCIHRDL AARNVLVTED SVMKIADFGL ARDIHHIDYY KKTTNGRLPV 660

KWMAPEVLYK NLYRVHWACL HRWSFGVLLW EIFTLGGSPY PGVPVEELFK LLKEGHRMDK 720

PSNCTNELYM MMRDCWHAVP SQRPTFKQLV EDLDRIVAMT SNQEYLDLSM PLDQYSPSFP 780

DTRSSTCSSG EDSVFSHDPL PDEPCLPKHP PQLANGGLKR R 821

Nucleotide Sequence
(FASTA)

ATGCCCGCTC GCCGTTGTCT GCATGCTGCC AGAGTTAATG CCTCTGCCAT AGTGCACTCA 60

TGCCTTGCTT TTCCCCTCCC TCCCTCTCTA TCCCTTTTTT CTCCCCTAAC ATTGCCAGTT 120

CTGCCCAAAA CAAGCATTGA AGTGGAGTCG TTGTCGGCTC ATCCCGGGGA CCCCCTCCAG 180

TTGCGCTGTC GGCTCCGCGA TGATGTTCAG AGCATCAACT GGGTTCGAGA CGGGGTCCAG 240

CTGGCTGAGA ACAACCGGAC ACGCATCACA GGGGAGGAGG TGGAGGTCAG GGATGCGGTG 300

CCCGAGGACT CCGGGCTCTA TGCTTGCATG ACCAACAGCC CCTCGGGAAG CGAGACCACC 360

TACTTCTCCG TTAACGTCTC AGATGCTCTT CCATCCGCTG AAGATGATGA CGACGACGAT 420

GATTCCTCCT CAGAGGAGAA GGAGGCAGAC AACTCCAAAC CGAATCGTAT GGTCACACCT 480

GTCTGGCTCT GTTGCCCATG CAGAGTGCAA TCTAGGATGC GGAGCACAGG AGCTGACAAG 540

ACGCTTGGCC CAACTTTGAG GTGGAGAAGC AAAGAGGACA CTGTCATTCT ATCAATGCAT 600

GCTTTCCTAG TTCGCCATGC AACCTGGAGC ATCATCATGG AATCCGTGGT GCCGTCAGAT 660

AAAGGCAACT ACACCTGCAT TGTGGAGAAC AAATACGGAA CTATCAACCA CACCTACCAG 720

CTTGATGTTG TTGAGAGGTC CCCTCACCGG CCTATTTTGC AAGCTGGCCT CCCCGCAAAC 780

AAGACCGTCT CCTTGGGTAG CAATGTAGAA TTTGTTTGCA AAGTCTACAG CGACCCTCAG 840

CCTCACATCC AGTGGCTGAA ACACATTGAG GTCAACGGGA GCAGGATTGG GCCAAACAAC 900

TTGCCCTACG TGCAGGTCTT GAAGACGGCT GGTGTTAACA CAACTGACAA AGAAATGGAA 960

GTCCTTCACT TAAGGAATGT CTCCTTTGAG GACGCTGGGC AGTATACCTG TTTGGCGGGT 1020

AATTCTATTG GGATCTCCCA CCACTCTGCA TGGTTGACGG TTCTGGAAGC CATGGAAGAC 1080

AAGCCTGCGA TGATGACCTC CCCGCTGTAC CTGGAGATCA TTATATACTG CACCGGGGGG 1140

TTCCTCATCT CCTGCATGAT TGTGACCGTC CTCCTCTACA AGATGAAGAG CACCACCAAG 1200

AAGACGGACT TCAACAGCCA GCTGGCCGTG CACAAGTTGG CCAAGAGCAT CCCTCTGCGC 1260

AGACAGGTAA CAGTCTCGGC TGACTCGAGC TCTTCCATGA ATTCAGGTGT GATGCTCATG 1320

CGCCCCTCGC GGCTTTCTTC CAGTGGGACT CCAATGCTGG CCGGTGTTTC TGAGTACGAC 1380

CTGCCAGAAG ACCCTCGCTG GGAGCTACCC AGAGACAGGC TGATTTTAGG TAAACCCTTG 1440

GGAGAAGGCT GCTTTGGGCA GGTGGTTCTC GCAGAAGCAA TAGGCCTGGA CAAAGACAAA 1500

CCGAACCGAG TAACTAAAGT GGCCGTAAAG ATGCTCAAAT CCGATGCCAC GGAAAAAGAT 1560

CTGTCTGATT TGATTTCTGA GATGGAGATG ATGAAAATGA TTGGCAAGCA TAAGAACATC 1620

ATCAACCTCC TCGGGGCTTG TACGCAGGAT GGTCCCCTCT ATGTGATAGT GGAGTATGCC 1680

TCCAAAGGCA ACCTGCGGGA ATACCTTCAA GCCCGGCGAC CCCCAGGCAT GGAATATTGC 1740

TACAACCCCA CCCACCTCCC CGATGAGCAG CTCTCCTTCA AAGACCTGGT CTCCTGTGCC 1800

TATCAAGTGG CCCGGGGCAT GGAATACCTG GCATCCAAAA AGTGCATCCA CCGAGACTTA 1860

GCCGCCAGGA ATGTGCTGGT GACGGAAGAC AGTGTGATGA AGATTGCTGA TTTTGGCTTG 1920

GCGCGAGATA TCCATCACAT AGATTACTAC AAGAAGACGA CAAATGGTCG CTTGCCGGTC 1980

AAATGGATGG CCCCTGAAGT CCTCTATAAG AACCTTTATA GAGTCCATTG GGCGTGTTTG 2040

CATAGGTGGT CCTTTGGAGT TCTGCTGTGG GAGATCTTCA CGTTGGGTGG ATCGCCGTAT 2100

CCAGGGGTTC CCGTGGAAGA ACTCTTCAAG CTGTTGAAAG AGGGCCATCG AATGGACAAG 2160

CCCAGCAACT GCACCAATGA GCTATACATG ATGATGCGAG ACTGCTGGCA TGCCGTTCCC 2220

TCCCAGAGAC CCACATTTAA GCAGCTGGTA GAAGACTTAG ATAGGATTGT GGCCATGACC 2280

TCAAACCAGG AATACCTGGA CCTCTCCATG CCACTGGACC AGTATTCTCC CAGTTTCCCA 2340

GACACCCGCA GCTCCACCTG CTCTTCTGGA GAGGACTCTG TGTTTTCCCA CGACCCCCTT 2400

CCTGATGAAC CTTGCCTTCC CAAGCACCCC CCTCAGCTTG CCAATGGAGG ACTCAAAAGA 2460

CGCTGA 2466

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l lgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 474   LILGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  533

         689*********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g+e+++++++ ++eql++

Q: 534   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGMEYCYNPTHLPDEQLSF  593

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvted+v+kiadfGlard+h+idyykkt

Q: 594   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDSVMKIADFGLARDIHHIDYYKKT  653

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqs...dvwsfGvllweiltlGgspypgiaveelfkllk  237

         tnGrlpvkwmape l +++y ++      wsfGvllwei+tlGgspypg++veelfkllk

Q: 654   TNGRLPVKWMAPEVLYKNLYRVHWaclHRWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK  713

         ********************987522257*******************************

S: 238   eGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         eGhrm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 714   EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  753

         **************************************97

Domain Sequence
(FASTA)

LILGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGMEYCYNP THLPDEQLSF 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDSVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEVLYKNLY RVHWACLHRW SFGVLLWEIF TLGGSPYPGV PVEELFKLLK 240

EGHRMDKPSN CTNELYMMMR DCWHAVPSQR PTFKQLVEDL 280

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013