EPS-AIM-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	151.9	1.1E-44	136	281	146

Status

Unreviewed

Ensembl Protein

ENSAMEP00000000020

UniProt Accession

G1KZH2;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000000020	ENSAMEP00000000020	ENSAMET00000000020

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1157

Protein Sequence
(FASTA)

QAVMATGGDP EEEQVVPNGE DEADVRAVQA QYLRSPSPSQ YSMVSDAETE SIFMEPIHLS 60

SAVAAKQIIN EEFKPRGIRA EAECPGMLES AEQLLVEDLY NRVKEKMDDT SLYNTPCVLD 120

LQRALVQDRQ EAPWNEVDEV WPNVFIAEKS VAVNKARLKR LGITHILNAA HGTGVYTGPE 180

FYTGLEIQYL GVEVDDFPEV DISQHFRKAA EFLDEALLTY RGKVLVSSEM GVSRSAVLVV 240

AYLMIFHDMA ILQALLTVRR KRAIYPNDGF LKQLRELNEK LMEEREEDSS QGGGTDEADV 300

ESDVGARAHA LTVQEEDDTC SHLSGSSWGR ASGASKPVTL IDEDEEERLY EEWKKGQGLP 360

TGKVPGGGDG RRSASNPGGE EPGDEDLDRM VEEWQSRNER YQAEGHQRWG REEEEEEAGE 420

AGSWQRRTRR HTLSESSTCE SVSSHDLRVV SQRLERGSQS PAGRRRSDSA STDSTWDMWN 480

QRLLEIEKEA SRRYRGRSRR EEADSSSEAG SRLREDDEES VASEASSFYN FCSRNKDKLT 540

ALERWKVKRI QFGFHKKELG AQDGSGEQGP EEAEREQKSS DVDLTAYQAW KLRHQKKVGS 600

ENKDEVVGLG KGEDSALAKK RQRRQELLER SRQTLEESQS VGSWEANSSV AGGSIPLSAF 660

CSAAPSVSAD DAASVLSAQS HGSRVSQAAS SAGGCLGSTP GAVLPALPVG PGDTISVASI 720

QNWIASVVSE TLAQKQNEML LWSRPPSVAS ARVAPAAGGL GDDQVSLLSG HSGSSSLGGC 780

LLLAGRRGPG SDVPSLLSSH EAGASRAEGP GSKVRGTSKP IYSLFADNVD LQELGRKERE 840

MRGDLRQKIC EYEMEKLASG NKRSSLFKKK KVKEDQEDGV GDRDGDTDSA IGSFQNSSRS 900

NSQKPETDTS SSLAVSDRCG TGGRAGKETD DGNIARWLRG VRTEEKSPPQ SDWSGSSRGK 960

YTRSSLLRET ESKSSSYKFS KSQSEEQDTA SYHEADGNSV RSISRISSSS TREGRETHKF 1020

SRSTFSETSS SREDSPEPYF FRRTPEASEG EASPEPRRPN WARPRDWEGV EESSSSDFAE 1080

FGAKRKFTQS FMRSEEEGER ERMEDREEGR FASGRRSQYR RSTDREEEEE MDDEAIIAAW 1140

RRRQEETRTK LQRRRED 1157

Nucleotide Sequence
(FASTA)

CAGGCTGTCA TGGCGACCGG TGGGGACCCA GAGGAGGAGC AGGTCGTCCC AAATGGAGAG 60

GATGAAGCCG ATGTGAGGGC CGTGCAGGCC CAGTACCTCC GGAGCCCCTC CCCCAGCCAG 120

TACTCGATGG TCTCAGATGC AGAAACAGAA AGCATTTTCA TGGAGCCCAT TCACCTCTCT 180

TCAGCGGTGG CAGCTAAACA GATCATCAAT GAAGAATTCA AGCCACGGGG GATCAGAGCC 240

GAGGCAGAAT GTCCGGGCAT GCTGGAGTCG GCCGAGCAGC TGCTGGTGGA GGACCTGTAC 300

AACCGTGTCA AGGAGAAGAT GGATGACACC AGCCTATACA ATACCCCCTG TGTCCTCGAT 360

TTACAGCGGG CCTTGGTCCA AGACCGCCAG GAGGCCCCCT GGAACGAGGT GGATGAGGTC 420

TGGCCCAATG TCTTCATAGC AGAGAAGAGT GTAGCTGTGA ACAAGGCAAG GCTGAAGAGG 480

CTGGGGATTA CTCACATCCT GAATGCTGCT CATGGCACCG GCGTCTACAC CGGGCCCGAA 540

TTCTACACTG GCCTGGAGAT TCAGTACTTG GGTGTGGAGG TCGATGACTT TCCCGAGGTG 600

GACATCTCCC AGCATTTCCG GAAGGCTGCT GAGTTCCTTG ATGAAGCCCT GTTGACCTAT 660

AGAGGGAAAG TGCTGGTCAG CAGCGAGATG GGCGTCAGCC GCTCAGCAGT GCTGGTGGTG 720

GCCTACCTCA TGATCTTCCA CGACATGGCC ATCCTGCAGG CCTTGCTGAC CGTGCGCAGG 780

AAGCGGGCCA TCTACCCCAA CGATGGCTTC CTGAAGCAGC TCCGTGAGCT CAACGAGAAG 840

CTGATGGAGG AGAGAGAGGA AGACTCCAGC CAGGGAGGGG GGACTGATGA GGCCGACGTG 900

GAGAGTGACG TCGGGGCCAG AGCGCACGCC CTCACCGTGC AGGAGGAGGA CGACACCTGC 960

AGCCACCTGA GTGGCTCGTC CTGGGGGAGG GCCAGCGGGG CGTCCAAGCC CGTCACCCTC 1020

ATTGACGAGG ATGAGGAGGA GAGGCTGTAC GAGGAGTGGA AGAAGGGGCA GGGCCTCCCC 1080

ACAGGCAAGG TCCCCGGGGG TGGGGACGGC CGTCGATCAG CCTCCAACCC GGGTGGGGAG 1140

GAGCCCGGGG ACGAGGACTT GGACAGGATG GTCGAGGAGT GGCAGAGCCG AAATGAGAGG 1200

TACCAGGCCG AGGGGCATCA GAGGTGGGGG AGGGAGGAGG AGGAGGAGGA GGCAGGCGAG 1260

GCCGGCTCGT GGCAGAGGAG GACACGGAGG CACACCCTGA GTGAGAGCAG CACCTGCGAG 1320

AGTGTCAGCA GCCACGACCT CCGGGTGGTG TCGCAGCGGC TGGAGAGGGG CAGCCAGAGC 1380

CCAGCCGGGA GACGCCGCTC CGACTCCGCG TCCACGGACA GCACGTGGGA CATGTGGAAC 1440

CAGAGGCTGC TGGAGATCGA GAAGGAAGCT TCCCGGCGCT ATCGCGGCAG GAGCCGGAGG 1500

GAGGAGGCCG ACAGCAGCTC TGAGGCGGGC AGCAGGCTGC GGGAGGACGA CGAGGAGAGC 1560

GTGGCTTCGG AGGCCAGCTC TTTCTACAAC TTCTGCAGCA GGAACAAGGA CAAGCTCACC 1620

GCTCTGGAAA GGTGGAAGGT CAAGCGAATC CAGTTTGGGT TTCACAAGAA AGAGTTGGGG 1680

GCGCAAGACG GCAGCGGTGA GCAGGGGCCA GAGGAGGCGG AGAGGGAGCA GAAGAGCTCG 1740

GACGTCGACC TGACGGCCTA CCAGGCCTGG AAACTGAGGC ACCAGAAGAA GGTGGGCAGC 1800

GAGAACAAGG ACGAGGTGGT GGGGCTCGGC AAGGGGGAGG ACTCTGCCTT GGCCAAGAAG 1860

AGGCAGCGGA GGCAGGAGCT GCTGGAGAGG AGCCGGCAGA CGTTGGAGGA GAGCCAGTCG 1920

GTGGGGAGCT GGGAGGCCAA CAGCTCGGTG GCCGGCGGGA GCATCCCACT GTCCGCCTTC 1980

TGCTCGGCCG CCCCCTCGGT CAGTGCGGAT GACGCGGCCT CGGTCCTCAG CGCCCAGAGC 2040

CATGGCTCCC GCGTCTCCCA GGCTGCGAGC AGCGCAGGCG GGTGCTTGGG CTCTACCCCG 2100

GGCGCCGTGC TGCCTGCCCT GCCCGTGGGG CCCGGCGACA CCATCTCTGT CGCCAGCATT 2160

CAGAACTGGA TCGCCAGTGT GGTCAGTGAG ACTCTGGCCC AGAAGCAAAA CGAAATGCTG 2220

CTGTGGTCCC GCCCGCCCTC CGTTGCCAGT GCGAGGGTGG CGCCCGCAGC CGGCGGCCTG 2280

GGGGACGACC AGGTCTCCCT GCTCAGCGGA CACAGCGGCT CGTCATCGCT GGGTGGCTGC 2340

CTGCTGCTCG CGGGTCGGCG GGGACCCGGC TCTGACGTGC CGTCCCTGCT GTCCTCCCAT 2400

GAGGCGGGGG CCTCGAGGGC CGAAGGCCCC GGGAGCAAAG TCAGGGGGAC CAGCAAGCCC 2460

ATCTATAGCC TCTTCGCCGA CAACGTGGAC CTCCAGGAGC TCGGCCGGAA GGAGAGGGAG 2520

ATGCGGGGGG ACCTGAGGCA GAAGATATGC GAGTACGAGA TGGAGAAGCT GGCCTCTGGC 2580

AACAAACGGA GCTCGCTTTT CAAGAAGAAG AAGGTCAAGG AAGACCAGGA GGATGGCGTG 2640

GGCGACAGGG ATGGAGACAC TGACAGTGCC ATTGGGAGCT TCCAGAATTC TTCCCGCAGT 2700

AACTCCCAAA AGCCTGAGAC AGACACCTCG TCCTCCCTGG CTGTCTCTGA TCGCTGCGGA 2760

ACTGGTGGCA GAGCGGGCAA GGAGACGGAC GATGGCAACA TCGCCAGGTG GCTCAGGGGC 2820

GTCAGGACAG AGGAAAAGTC TCCCCCCCAA AGCGATTGGT CTGGAAGCTC CAGGGGGAAG 2880

TACACCAGAT CTTCCCTGCT CCGGGAGACG GAGTCCAAGT CCTCCAGCTA CAAGTTCTCC 2940

AAATCGCAGT CGGAAGAGCA GGACACGGCC TCCTACCATG AGGCCGATGG CAACTCCGTA 3000

AGGAGCATTT CGCGGATCTC TTCTTCCTCT ACCAGGGAGG GCAGAGAGAC GCACAAATTC 3060

TCCAGGTCAA CGTTCAGCGA GACCTCAAGC TCCCGAGAGG ACAGCCCAGA GCCCTACTTC 3120

TTCCGCCGGA CCCCCGAGGC CTCCGAAGGG GAGGCGTCCC CGGAACCACG GCGTCCGAAC 3180

TGGGCCAGGC CCAGGGACTG GGAAGGTGTG GAAGAGTCGT CCAGCTCAGA CTTTGCTGAA 3240

TTTGGAGCCA AGAGGAAATT CACCCAGAGC TTCATGAGGT CCGAGGAGGA GGGAGAAAGA 3300

GAGAGGATGG AAGACAGAGA AGAAGGGAGG TTTGCTTCGG GGCGGCGGTC CCAGTACCGG 3360

AGGAGCACTG ACAGGGAGGA GGAGGAAGAA ATGGACGATG AGGCCATCAT TGCCGCCTGG 3420

AGACGCCGGC AGGAAGAGAC CAGGACGAAG CTGCAGAGAA GGAGGGAGGA TTGA 3474

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 136   EVDEVWPNVFIAEKSVAVNKARLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  194

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++GvsRSa+lv+aYLm+++++++ +A

Q: 195   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGVSRSAVLVVAYLMIFHDMAILQA  254

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         + +v+rkr +i+pn+gfl+QL+el++kl

Q: 255   LLTVRRKR-AIYPNDGFLKQLRELNEKL  281

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK ARLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGVSRS AVLVVAYLMI FHDMAILQAL 120

LTVRRKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013