EKS-AIM-00378
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00378
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK404.72.2E-121135413279
StatusUnreviewed
Ensembl ProteinENSAMEP00000000111
UniProt AccessionG1KZR0;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK3
Gene Synonyms/Alias IRAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000000105ENSAMEP00000000111ENSAMET00000000115
OrganismAiluropoda melanoleuca
Functional Description
Protein Length566
Protein Sequence
(FASTA)
IAERLSSSWL DVRHIEKYVD QGKSGTRELL WSWAQKNKTI GDLLQILQEM GHHRAIHLIV 60
NHGAVLNPSE QSHPGDGFPN MLPKVECMCI VNELGIEETA NVTADNVLIP ECNEKGILFK 120
SSISFQNIID GTKNFHKDFL IGEGEIFEVY RAEIQNRTYA IKLFKQEKKM QCKKQWKRFL 180
SELEVLLLFH HPNILELAAY FTESEKFCLV YPYMRNGSLF DRLQCVGNTA PLSWHIRISV 240
LIGASKAIQY LHNTEPCSVV CGNVSSANIL LDNQFQPKLT DFGMAHFRPH MEHQSSTISM 300
ASSSRKHLWY MPEEYIRQGK LSIKTDVYSF GIVIMEVLTG RKVVLDDPKH IQLRDLLMEL 360
MEKRGLDSCL SFLDKKVHPC PRNFSAKLFS LAGQCATTRA KLRPSMDEVL NTLESTQASL 420
YFAEDPPTSL KSFRCPSPLF LENVPSIPVE DDENQNNRSP PPDKGLRKDR VTQKVPFECS 480
QSEVTFLGFD RKKGSERNED ACNRPSSSCQ ESWSPKHAAL CQDPRAYGTD TEPSAEAPGH 540
SYRSRPVETS CSCEFSWNEC EPYKRE 566
Nucleotide Sequence
(FASTA)
ATAGCGGAGC GACTTTCAAG CAGCTGGCTG GATGTTCGTC ACATTGAAAA ATATGTAGAC 60
CAAGGTAAAA GTGGAACAAG AGAATTACTT TGGTCCTGGG CACAGAAAAA CAAGACCATC 120
GGCGACCTTT TACAGATTCT CCAGGAGATG GGGCATCATC GAGCTATCCA TTTAATTGTG 180
AACCATGGAG CAGTCTTGAA TCCTTCAGAG CAGAGTCATC CGGGAGATGG ATTTCCAAAC 240
ATGTTGCCCA AGGTAGAGTG TATGTGCATA GTTAATGAAT TGGGAATTGA GGAAACAGCC 300
AATGTCACAG CGGATAATGT TCTTATTCCT GAATGTAATG AAAAAGGAAT ATTGTTTAAA 360
TCCTCCATCA GCTTTCAAAA CATCATAGAC GGAACCAAAA ATTTCCATAA AGACTTTCTA 420
ATTGGAGAAG GGGAGATTTT TGAAGTATAT AGAGCGGAGA TTCAAAACCG AACATATGCC 480
ATTAAATTAT TTAAACAGGA GAAAAAAATG CAGTGTAAGA AACAATGGAA GAGGTTTTTA 540
TCTGAGCTTG AAGTTTTACT ACTGTTTCAT CATCCAAACA TACTGGAGTT GGCTGCCTAT 600
TTTACAGAGA GTGAGAAGTT CTGCCTGGTT TATCCATATA TGAGAAATGG ATCCCTTTTT 660
GACAGATTAC AGTGTGTAGG CAACACGGCC CCACTTTCTT GGCACATTCG AATCAGTGTT 720
TTAATAGGAG CCTCCAAAGC CATTCAGTAC TTGCACAACA CGGAGCCGTG CTCGGTTGTC 780
TGCGGCAATG TATCAAGTGC AAACATACTT TTGGATAATC AGTTCCAACC CAAACTCACT 840
GATTTTGGCA TGGCACACTT CCGACCGCAC ATGGAACATC AGAGCTCTAC CATCAGCATG 900
GCCAGCAGCA GCAGGAAACA TCTGTGGTAT ATGCCTGAAG AGTACATCAG ACAGGGCAAA 960
CTTTCCATTA AAACGGACGT CTATAGCTTT GGAATTGTAA TAATGGAAGT TCTGACAGGT 1020
CGTAAAGTGG TGTTAGATGA TCCAAAGCAT ATCCAGCTGA GGGATCTCCT TATGGAATTG 1080
ATGGAGAAGA GAGGCCTCGA TTCATGTCTT TCATTTCTGG ATAAGAAAGT GCATCCCTGT 1140
CCTCGGAATT TCTCTGCCAA GCTCTTCTCT TTGGCAGGCC AGTGTGCTAC CACGCGGGCC 1200
AAGTTAAGAC CGTCAATGGA TGAAGTCCTG AACACTCTTG AAAGTACTCA GGCCAGCTTA 1260
TATTTTGCTG AGGATCCTCC CACCTCCCTA AAGTCCTTCA GGTGTCCTTC TCCTCTGTTC 1320
TTGGAGAACG TACCAAGTAT TCCAGTGGAA GATGATGAAA ACCAGAATAA TCGTTCACCG 1380
CCTCCTGATA AAGGTTTGAG AAAAGATAGA GTGACTCAGA AAGTTCCATT TGAATGTAGC 1440
CAGTCTGAGG TTACATTTCT GGGCTTTGAC AGAAAGAAAG GCAGTGAGAG AAATGAGGAT 1500
GCCTGCAACA GGCCCAGTTC GTCTTGTCAA GAAAGTTGGT CTCCAAAGCA CGCAGCTCTA 1560
TGCCAGGACC CAAGGGCCTA TGGTACGGAT ACGGAGCCTT CTGCGGAAGC TCCAGGCCAT 1620
TCTTACAGGA GCAGGCCGGT GGAGACCAGC TGTTCCTGCG AATTTTCCTG GAACGAATGT 1680
GAACCATACA AAAGGGAA 1698
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         f++d+ igeG+++evyr+e++n ++a+k +k+e+++++k+ +++fl+El+vl+ f+H+ni
Q: 135   FHKDFLIGEGEIFEVYRAEIQNRTYAIKLFKQEKKMQCKKQWKRFLSELEVLLLFHHPNI  194
         89**********************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120
         lel++y++esek+cLvY+ym+nGsL+drLqc ++++pLsW++R+s+l+G+++ai++LH++
Q: 195   LELAAYFTESEKFCLVYPYMRNGSLFDRLQCVGNTAPLSWHIRISVLIGASKAIQYLHNT  254
         ************************************************************
S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179
         +p s+++g+++saNiLLD++++pKl+Dfg+a+f+p+ e+qsst+ ++s+ r++l+Y+pee
Q: 255   EPcSVVCGNVSSANILLDNQFQPKLTDFGMAHFRPHMEHQSSTISMASSSRKHLWYMPEE  314
         ************************************************************
S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239
         +ir+g+l++k+DvySfGiV++EvltG+++v +d+k+ +L+dll+e +e+++++++ +fld
Q: 315   YIRQGKLSIKTDVYSFGIVIMEVLTGRKVVLDDPKHIQLRDLLMELMEKRGLDSCLSFLD  374
         ************************************************************
S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278
         kk+ +++++++++l++la++c+ ++ak rP+m++vl++l
Q: 375   KKVHPCPRNFSAKLFSLAGQCATTRAKLRPSMDEVLNTL  413
         ***********************************9987
Domain Sequence
(FASTA)
FHKDFLIGEG EIFEVYRAEI QNRTYAIKLF KQEKKMQCKK QWKRFLSELE VLLLFHHPNI 60
LELAAYFTES EKFCLVYPYM RNGSLFDRLQ CVGNTAPLSW HIRISVLIGA SKAIQYLHNT 120
EPCSVVCGNV SSANILLDNQ FQPKLTDFGM AHFRPHMEHQ SSTISMASSS RKHLWYMPEE 180
YIRQGKLSIK TDVYSFGIVI MEVLTGRKVV LDDPKHIQLR DLLMELMEKR GLDSCLSFLD 240
KKVHPCPRNF SAKLFSLAGQ CATTRAKLRP SMDEVLNTL 279
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00407
EKS-CAJ-00410
EKS-CAF-00407
EKS-CAP-00435
EKS-DAR-00794
EKS-ECT-00006
EKS-EQC-00399
EKS-ERE-00006
EKS-FEC-00390
EKS-GAA-00494
EKS-GOG-00398
EKS-HOS-00413
EKS-ICT-00386
EKS-LAC-00422
EKS-LOA-00416
EKS-MAM-00405
EKS-MOD-00398
EKS-MUM-00439
EKS-MUP-00401
EKS-MYL-00402
EKS-NOL-00370
EKS-OCP-00086
EKS-ORN-00520
EKS-ORA-00355
EKS-ORC-00382
EKS-OTG-00409
EKS-PAT-00385
EKS-PEM-00222
EKS-POA-00397
EKS-RAN-00421
EKS-SAH-00378
EKS-SUS-00359
EKS-TAR-00515
EKS-TUT-00121
EKS-VIP-00063
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0045824; P:negative regulation of innate immune response
GO:0010936; P:negative regulation of macrophage cytokine production
GO:0043407; P:negative regulation of MAP kinase activity
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177; P:negative regulation of protein catabolic process
GO:0043242; P:negative regulation of protein complex disassembly
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0010933; P:positive regulation of macrophage tolerance induction
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0043330; P:response to exogenous dsRNA
GO:0032496; P:response to lipopolysaccharide
GO:0032494; P:response to peptidoglycan
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013