EKS-AIM-00144

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00144

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	517.4	1.1E-155	89	382	294

Status

Unreviewed

Ensembl Protein

ENSAMEP00000000311

UniProt Accession

G1L0A9;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000000274	ENSAMEP00000000311	ENSAMET00000000322

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

470

Protein Sequence
(FASTA)

MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE 60

EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240

HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF 360

CCEWEHRIGA PGVEEIKSNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK 420

PTGISFPVAT SNHPETDYKN KDWVFVNYTY KRFEGLTARG AIPSYMKAAK 470

Nucleotide Sequence
(FASTA)

ATGGCAATGA CAGGCTCAAC ACCTTGTTCC TCCATGAGTA ATCACACAAA GGAAAGGGTG 60

ACCATGACCA AAGTGACACT GGAGAATTTT TACAGCAACC TTATCGCTCA ACATGAAGAA 120

CGAGAAATGA GACAAAAGAA GTTAGAAAAA GTGATGGAAG AAGAAGGCCT AAAAGATGAA 180

GAGAAGCGAC TGAGGAGATC AGCGCATGCT CGGAAGGAAA CAGAGTTTCT CCGTTTGAAG 240

AGAACAAGAC TTGGATTGGA AGATTTTGAG TCCTTAAAAG TAATAGGCAG AGGAGCATTC 300

GGTGAGGTGC GGCTTGTTCA GAAGAAAGAT ACAGGGCATG TGTATGCAAT GAAAATACTC 360

CGTAAAGCAG ATATGCTTGA AAAAGAGCAG GTCGGCCACA TTCGTGCGGA GCGCGACATT 420

CTAGTGGAGG CAGACAGTTT GTGGGTTGTG AAAATGTTCT ATAGTTTTCA GGATAAGCTA 480

AACCTCTACC TAATCATGGA GTTCCTGCCT GGAGGGGACA TGATGACCCT ATTAATGAAA 540

AAAGATACCC TGACGGAAGA GGAGACTCAG TTTTATATAG CAGAAACAGT GTTAGCCATA 600

GACTCCATTC ACCAACTTGG ATTCATCCAC AGAGACATCA AGCCAGACAA CCTTCTCCTG 660

GACAGCAAGG GCCATGTGAA GCTTTCTGAC TTTGGCCTTT GCACAGGATT GAAAAAAGCA 720

CATAGGACAG AATTTTATAG GAATCTGAAC CACAGCCTCC CCAGTGATTT CACTTTCCAG 780

AACATGAATT CCAAAAGGAA AGCAGAGACC TGGAAAAGAA ATAGACGTCA GCTAGCCTTC 840

TCCACAGTAG GCACTCCTGA CTACATCGCT CCTGAGGTGT TCATGCAGAC CGGGTACAAC 900

AAGCTCTGTG ACTGGTGGTC GCTTGGGGTC ATCATGTATG AGATGCTCAT CGGCTACCCA 960

CCTTTCTGTT CTGAGACCCC TCAAGAGACA TATAAGAAGG TGATGAACTG GAAAGAAACT 1020

TTGACTTTTC CTCCAGAAGT TCCTATCTCT GAGAAAGCCA AGGATCTAAT TTTGAGATTC 1080

TGCTGTGAGT GGGAACATAG AATTGGAGCC CCTGGAGTTG AGGAAATCAA AAGTAACTCT 1140

TTTTTTGAAG GCGTTGACTG GGAACATATC AGAGAGAGAC CTGCTGCAAT CTCTATTGAA 1200

ATCAAAAGCA TTGATGATAC CTCAAACTTC GATGAGTTTC CAGAATCTGA TATTCTTAAG 1260

CCAACAGGTA TTTCTTTCCC AGTGGCTACA AGTAATCACC CCGAGACCGA CTACAAGAAC 1320

AAAGACTGGG TCTTCGTCAA TTACACGTAC AAGCGCTTTG AGGGCCTGAC GGCTCGGGGG 1380

GCAATACCTT CCTACATGAA AGCGGCCAAA TAG 1413

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++

Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMNS  264

         *************************************************555....5555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5544556*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqetykkv+nwketl+fp+ev++se+akdli r+++++e+r+g+ Gv+eik+++ff

Q: 325   ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFF  382

         *********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LNHSLPSDFT FQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYKKVMNWK ETLTFPPEVP ISEKAKDLIL RFCCEWEHRI GAPGVEEIKS NSFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013