EKS-AIM-00170

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00170

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	859.3	9.1E-259	76	649	574

Status

Unreviewed

Ensembl Protein

ENSAMEP00000000572

UniProt Accession

D2GYW2;

Protein Name

Protein Synonyms/Alias

Putative uncharacterized protein;

Gene Name

SRPK1

Gene Synonyms/Alias

PANDA_002225;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000000501	ENSAMEP00000000572	ENSAMET00000000592

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

651

Protein Sequence
(FASTA)

VLALQARKKR TKAKKDKAQR KSETQHRGSA PHSESDLPEQ EEEILGSDDD EQEDPNDYCK 60

GGYHLVKIGD LFNGRYHVIR KLGWGHFSTV WLSWDIQGKK FVAMKVVKSA EHYTETALDE 120

IRLLKSVRNS DPNDPNREMV VQLLDDFKIS GVNGTHICMV FEVLGHHLLK WIIKSNYQGL 180

PLPCVKKIIQ QVLQGLDYLH TKCRIIHTDI KPENILLSVN EQYIRRLAAE ATEWQRSGAP 240

PPSGSAVSTA PQPKPADKMS KNKKKKLKKK QKRQAELLEK RMQEIEEMEK ESGPGQKRPN 300

KQEESESPVE RPLKENPPNK MTQEKLEESS TIDQDQTLME RGVEGGAAEI NCNGVIEIVN 360

YTENSNKETL RLKEDLRNAN DCDVQNLKQE PSFLSSQNGD SSTSQETDSC TPVTSEVSDT 420

MMCQASPNVD QSFSEQDISQ LQESIRAEIP CEDGQEQEQN GPLDNKGKST AGNFLVNPLE 480

PKNAEKLQVK IADLGNACWV HKHFTEDIQT RQYRSLEVLI GSGYNTPADI WSTACMAFEL 540

ATGDYLFEPH SGEEYTRDED HIALIIELLG KVPRKLIVAG KYSKEFFTKK GDLKHITKLK 600

PWGLFEVLVE KYEWSQEEAA GFTDFLLPML ELIPEKRATA AECLRHPWLN S 651

Nucleotide Sequence
(FASTA)

GTGCTTGCGC TCCAGGCCCG AAAGAAAAGG ACCAAGGCCA AGAAGGACAA AGCCCAAAGG 60

AAATCTGAAA CTCAGCACCG AGGCTCTGCT CCCCACTCTG AAAGTGATCT ACCGGAGCAG 120

GAAGAAGAGA TTCTGGGGTC TGATGATGAT GAGCAAGAAG ATCCCAATGA TTATTGTAAA 180

GGAGGTTATC ATCTTGTGAA AATTGGAGAT CTATTCAATG GGAGATATCA CGTGATCCGA 240

AAGTTGGGCT GGGGACACTT TTCAACAGTG TGGTTATCAT GGGATATTCA GGGGAAGAAG 300

TTTGTGGCAA TGAAAGTAGT TAAAAGTGCT GAACATTATA CTGAAACAGC ACTAGATGAA 360

ATCCGGTTGC TGAAATCAGT ACGTAATTCA GACCCTAATG ATCCAAATAG AGAAATGGTC 420

GTTCAACTAC TAGATGACTT CAAAATATCA GGAGTTAATG GAACACATAT CTGCATGGTG 480

TTTGAAGTTT TGGGGCATCA TCTGCTCAAG TGGATCATCA AGTCCAATTA TCAAGGGCTT 540

CCACTGCCTT GTGTCAAAAA AATTATCCAG CAAGTGTTAC AGGGTCTGGA TTATTTACAC 600

ACCAAGTGCC GTATCATCCA CACTGACATT AAACCAGAAA ACATCTTGTT GTCAGTGAAC 660

GAGCAGTATA TCCGAAGACT GGCTGCAGAA GCAACAGAAT GGCAGCGATC TGGAGCTCCT 720

CCACCTTCTG GATCTGCAGT CAGTACTGCG CCCCAGCCTA AACCAGCTGA CAAAATGTCA 780

AAGAATAAGA AGAAGAAATT GAAGAAGAAG CAGAAGCGCC AGGCAGAATT ACTAGAGAAG 840

CGAATGCAGG AAATTGAGGA AATGGAGAAA GAGTCGGGCC CTGGGCAAAA AAGACCAAAC 900

AAGCAAGAAG AATCAGAGAG TCCTGTTGAA AGACCCTTGA AAGAGAACCC ACCTAATAAA 960

ATGACCCAAG AAAAACTTGA AGAGTCAAGT ACCATTGACC AGGATCAAAC ACTTATGGAA 1020

CGTGGTGTAG AGGGTGGTGC AGCAGAAATT AATTGCAATG GAGTAATTGA AATCGTTAAT 1080

TATACTGAAA ACAGTAATAA AGAAACATTG AGGCTTAAAG AGGATCTACG TAATGCTAAT 1140

GACTGTGATG TCCAAAATTT GAAGCAGGAA CCTAGTTTCC TAAGCTCCCA AAATGGAGAC 1200

AGCAGCACAT CTCAAGAAAC AGACTCTTGC ACACCTGTAA CCTCTGAGGT GTCAGATACC 1260

ATGATGTGCC AGGCTTCACC AAATGTAGAC CAGTCATTCA GTGAACAGGA CATCAGCCAA 1320

CTTCAAGAAA GCATTCGGGC GGAGATACCC TGTGAAGACG GGCAAGAGCA AGAACAAAAT 1380

GGACCATTGG ACAACAAAGG AAAATCCACT GCTGGAAATT TTCTTGTTAA TCCCCTTGAG 1440

CCAAAAAATG CAGAAAAGCT CCAAGTGAAG ATTGCTGATC TTGGAAATGC CTGTTGGGTG 1500

CACAAACATT TCACTGAAGA TATTCAAACA AGGCAGTATC GCTCCTTGGA AGTTCTGATA 1560

GGATCTGGCT ATAACACCCC GGCTGACATT TGGAGCACAG CATGCATGGC CTTTGAACTG 1620

GCCACAGGCG ACTATTTGTT TGAGCCTCAT TCAGGGGAAG AGTACACTCG AGATGAAGAT 1680

CACATTGCAT TGATCATAGA ACTTCTGGGG AAGGTGCCTC GCAAGCTCAT TGTGGCAGGA 1740

AAATATTCCA AGGAATTTTT CACCAAAAAA GGTGACCTGA AACACATCAC GAAACTGAAA 1800

CCCTGGGGCC TTTTTGAGGT TCTAGTGGAG AAGTATGAGT GGTCTCAGGA AGAGGCAGCT 1860

GGCTTCACGG ATTTCTTACT GCCCATGTTG GAGCTGATAC CCGAGAAGAG AGCCACTGCC 1920

GCCGAGTGTC TCCGGCACCC TTGGCTCAAC TCC 1953

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWL+wd+q+k+fva+kvvksaehytetaldei+llksvr+sdp+dp

Q: 76    YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDP  135

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         +re+vvqllddfkisGvnG+h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 136   NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG  195

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+++yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 196   LDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  255

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 256   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkesgpgqkrpnkqeesespverplke  315

         ************************************************************

S: 215   ..........aaeanseaedqelkedaekgeleeieadveeevanedeaseeee......  258

                   ++e++++ +dq+l+e+  +g+++ei+++ ++e++n++e+s++e+

Q: 316   nppnkmtqekLEESSTIDQDQTLMERGVEGGAAEINCNGVIEIVNYTENSNKETlrlked  375

         *********999999**********************************99999999999

S: 259   ..............essltsssdaesksgelseastellsesleqlacgsvls.......  297

                       e s++ss++ +s+++++++++t+++se++++++c+++ +

Q: 376   lrnandcdvqnlkqEPSFLSSQNGDSSTSQETDSCTPVTSEVSDTMMCQASPNvdqsfse  435

         99999999***999***********************************998899*****

S: 298   ........................................vnplepknadkikvkiadLG  317

                                                 vnplepkna+k++vkiadLG

Q: 436   qdisqlqesiraeipcedgqeqeqngpldnkgkstagnflVNPLEPKNAEKLQVKIADLG  495

         ************************************************************

S: 318   naCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfephsgedy  377

         naCwvhkhftediqtrqyrslevliG+gy+tpadiWstaC+afeLatGdyLfephsge+y

Q: 496   NACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEY  555

         ************************************************************

S: 378   srdedhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLlevLvekyews  437

         +rdedhia iiellGk+Prkli++Gkys+eff+kkg+L+hitkLkpw+L+evLvekyews

Q: 556   TRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWS  615

         ************************************************************

S: 438   keeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         +eeaa f+dfLlPmlel+pekra+aaecl+hpwL

Q: 616   QEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL  649

         *********************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLSWD IQGKKFVAMK VVKSAEHYTE TALDEIRLLK SVRNSDPNDP 60

NREMVVQLLD DFKISGVNGT HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIQQVLQG 120

LDYLHTKCRI IHTDIKPENI LLSVNEQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKESGPG QKRPNKQEES ESPVERPLKE 240

NPPNKMTQEK LEESSTIDQD QTLMERGVEG GAAEINCNGV IEIVNYTENS NKETLRLKED 300

LRNANDCDVQ NLKQEPSFLS SQNGDSSTSQ ETDSCTPVTS EVSDTMMCQA SPNVDQSFSE 360

QDISQLQESI RAEIPCEDGQ EQEQNGPLDN KGKSTAGNFL VNPLEPKNAE KLQVKIADLG 420

NACWVHKHFT EDIQTRQYRS LEVLIGSGYN TPADIWSTAC MAFELATGDY LFEPHSGEEY 480

TRDEDHIALI IELLGKVPRK LIVAGKYSKE FFTKKGDLKH ITKLKPWGLF EVLVEKYEWS 540

QEEAAGFTDF LLPMLELIPE KRATAAECLR HPWL 574

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013