EPS-AIM-00070
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-AIM-00070
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/PTEN300.84.5E-9014185172
StatusUnreviewed
Ensembl ProteinENSAMEP00000000745
UniProt AccessionD2GZ33;
Protein Name
Protein Synonyms/Alias
Gene NamePTEN
Gene Synonyms/Alias PTEN; PANDA_002317;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000000698ENSAMEP00000000745ENSAMET00000000771
OrganismAiluropoda melanoleuca
Functional Description
Protein Length403
Protein Sequence
(FASTA)
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 60
HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 120
AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 180
LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY 240
FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 300
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 360
SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI TKV 403
Nucleotide Sequence
(FASTA)
ATGACAGCCA TCATCAAAGA GATCGTTAGC AGAAACAAAA GGAGATATCA AGAGGATGGA 60
TTCGACTTAG ACTTGACCTA TATTTATCCC AACATTATTG CTATGGGGTT TCCTGCAGAA 120
AGACTTGAAG GCGTATACAG GAACAATATT GATGATGTAG TAAGGTTTTT GGATTCAAAG 180
CATAAAAACC ATTACAAGAT ATACAATCTG TGTGCTGAAA GACATTATGA TACCGCCAAA 240
TTTAACTGCA GAGTTGCACA GTATCCTTTT GAAGACCATA ATCCACCACA ACTAGAACTT 300
ATCAAACCCT TTTGTGAAGA TCTTGACCAA TGGCTAAGTG AAGATGACAA TCATGTTGCA 360
GCAATTCACT GTAAAGCTGG AAAGGGACGA ACTGGTGTAA TGATTTGTGC ATATTTATTA 420
CATCGGGGCA AATTTTTAAA GGCACAAGAG GCCCTAGATT TCTATGGGGA AGTAAGGACC 480
AGAGACAAAA AGGGAGTAAC TATTCCCAGT CAGAGGCGCT ATGTGTATTA TTATAGCTAC 540
CTGTTAAAGA ATCATCTGGA TTATAGACCA GTGGCACTGT TGTTTCACAA GATGATGTTT 600
GAAACTATTC CAATGTTCAG TGGCGGAACT TGCAATCCTC AGTTTGTGGT CTGCCAGCTA 660
AAGGTGAAGA TCTATTCCTC CAATTCAGGA CCCACACGAC GGGAAGACAA GTTCATGTAC 720
TTCGAGTTCC CTCAGCCGTT ACCTGTGTGT GGTGACATCA AAGTAGAGTT CTTCCACAAA 780
CAGAACAAGA TGCTAAAAAA GGACAAAATG TTTCACTTTT GGGTAAACAC ATTCTTCATA 840
CCAGGACCAG AGGAAACCTC AGAAAAAGTA GAAAATGGAA GTCTATGTGA TCAAGAAATT 900
GATAGTATTT GCAGTATAGA GCGTGCAGAT AATGACAAGG AATATCTAGT ACTCACTTTA 960
ACAAAAAATG ATCTCGACAA AGCAAATAAA GACAAGGCCA ACCGATACTT TTCTCCAAAT 1020
TTTAAGGTGA AGCTGTACTT CACGAAAACA GTAGAGGAGC CATCAAATCC CGAGGCTAGC 1080
AGTTCAACTT CTGTAACACC AGACGTTAGT GACAATGAAC CTGACCATTA TCGATATTCT 1140
GACACCACTG ACTCTGATCC AGAGAATGAA CCTTTTGATG AAGATCAGCA TACACAGATT 1200
ACAAAAGTC 1209
Domain Profile
S: 1     rrltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcse  60
         rr++edgfdldlty++++iia++fPae+ e+vyrnn+++vvr+ldskh+n+yk+ynlc+e
Q: 14    RRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAE  73
         79**********************************************************
S: 61    rrydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGv  120
         r+yd++k+n++va++++ed+n+P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv
Q: 74    RHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGV  133
         ************************************************************
S: 121   ivcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkgs  174
         ++cayll++++++ka+eald++ge+rtr++k  gv++Psqrryv+y+s+llk++
Q: 134   MICAYLLHRGKFLKAQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNH  185
         *******************************..******************986
Domain Sequence
(FASTA)
RRYQEDGFDL DLTYIYPNII AMGFPAERLE GVYRNNIDDV VRFLDSKHKN HYKIYNLCAE 60
RHYDTAKFNC RVAQYPFEDH NPPQLELIKP FCEDLDQWLS EDDNHVAAIH CKAGKGRTGV 120
MICAYLLHRG KFLKAQEALD FYGEVRTRDK KGVTIPSQRR YVYYYSYLLK NH 172
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EPS-ANC-00070
EPS-BOT-00060
EPS-CAE-00090
EPS-CAJ-00060
EPS-CAF-00075
EPS-CAP-00056
EPS-CHH-00018
EPS-CII-00031
EPS-CIS-00020
EPS-DAR-00103
EPS-DIO-00023
EPS-DRM-00027
EPS-EQC-00058
EPS-ERE-00015
EPS-FEC-00070
EPS-GAM-00057
EPS-GAG-00064
EPS-GAA-00095
EPS-GOG-00071
EPS-HOS-00056
EPS-ICT-00059
EPS-LAC-00074
EPS-LOA-00054
EPS-MAM-00059
EPS-MEG-00066
EPS-MOD-00058
EPS-MUM-00056
EPS-MYL-00058
EPS-NOL-00066
EPS-ORN-00073
EPS-ORC-00054
EPS-ORL-00083
EPS-OTG-00058
EPS-PAT-00053
EPS-PES-00071
EPS-POA-00072
EPS-RAN-00059
EPS-SAH-00057
EPS-SUS-00058
EPS-TAG-00068
EPS-TAR-00092
EPS-TAS-00020
EPS-TEN-00069
EPS-VIP-00021
EPS-XET-00068
EPS-XIM-00102
EPS-SCP-00017
Gene Ontology
GO:0042995; C:cell projection
GO:0005737; C:cytoplasm
GO:0009898; C:internal side of plasma membrane
GO:0035749; C:myelin sheath adaxonal region
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287; F:magnesium ion binding
GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438; F:phosphatidylinositol-3-phosphatase activity
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0001525; P:angiogenesis
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0048738; P:cardiac muscle tissue development
GO:0032286; P:central nervous system myelin maintenance
GO:0021955; P:central nervous system neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0021542; P:dentate gyrus development
GO:0043542; P:endothelial cell migration
GO:0048853; P:forebrain morphogenesis
GO:0006917; P:induction of apoptosis
GO:0046855; P:inositol phosphate dephosphorylation
GO:0007611; P:learning or memory
GO:0045475; P:locomotor rhythm
GO:0060291; P:long-term synaptic potentiation
GO:0060179; P:male mating behavior
GO:0042711; P:maternal behavior
GO:0033555; P:multicellular organismal response to stress
GO:0043066; P:negative regulation of apoptotic process
GO:0050771; P:negative regulation of axonogenesis
GO:0090344; P:negative regulation of cell aging
GO:0030336; P:negative regulation of cell migration
GO:0045792; P:negative regulation of cell size
GO:0031658; P:negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0061002; P:negative regulation of dendritic spine morphogenesis
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential
GO:0051895; P:negative regulation of focal adhesion assembly
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle
GO:0031642; P:negative regulation of myelination
GO:0046621; P:negative regulation of organ growth
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0090071; P:negative regulation of ribosome biogenesis
GO:2000808; P:negative regulation of synaptic vesicle clustering
GO:0007270; P:neuron-neuron synaptic transmission
GO:0046856; P:phosphatidylinositol dephosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential
GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107; P:postsynaptic density assembly
GO:0060134; P:prepulse inhibition
GO:0097105; P:presynaptic membrane assembly
GO:0060736; P:prostate gland growth
GO:0043491; P:protein kinase B signaling cascade
GO:0050821; P:protein stabilization
GO:0002902; P:regulation of B cell apoptotic process
GO:0033032; P:regulation of myeloid cell apoptotic process
GO:0060024; P:rhythmic synaptic transmission
GO:0035176; P:social behavior
GO:0060074; P:synapse maturation
KEGG
aml:100469483;
InterPros
IPR017361; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR014019; Phosphatase_tensin-typ.
IPR014020; Tensin_phosphatase_C2-dom.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
PF10409; PTEN_C2; 1.
SMARTs
Prosites
PS51182; C2_TENSIN; 1.
PS51181; PPASE_TENSIN; 1.
PS00383; TYR_PHOSPHATASE_1; 1.
Prints
Created Date20-Feb-2013