EPS-AIM-00067

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00067

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP1	414.9	4.6E-125	58	251	194

Status

Unreviewed

Ensembl Protein

ENSAMEP00000000800

UniProt Accession

G1L1P7;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP1CA

Gene Synonyms/Alias

PPP1CA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000000758	ENSAMEP00000000800	ENSAMET00000000830

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

330

Protein Sequence
(FASTA)

MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK 60

ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 120

LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 180

QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD 240

LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD 300

KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK 330

Nucleotide Sequence
(FASTA)

ATGTCCGACA GCGAGAAGCT CAACCTGGAC TCTATCATCG GGCGCCTGCT GGAAGTGCAG 60

GGCTCGCGGC CTGGAAAGAA TGTACAGCTA ACAGAGAACG AGATCCGTGG TCTGTGCCTC 120

AAATCACGGG AGATTTTCCT GAGCCAGCCC ATTCTTCTGG AACTGGAGGC ACCCCTCAAG 180

ATCTGCGGTG ACATCCATGG CCAGTACTAC GACCTTCTGC GGCTATTTGA GTATGGCGGC 240

TTCCCTCCAG AGAGCAACTA CCTCTTCCTG GGGGACTACG TGGACCGGGG CAAGCAGTCT 300

TTGGAGACCA TCTGCCTGCT GCTGGCCTAT AAGATCAAGT ACCCTGAGAA CTTCTTCCTG 360

CTCCGTGGGA ACCACGAATG TGCCAGCATC AACCGCATCT ACGGCTTCTA TGATGAGTGC 420

AAGAGACGCT ACAACATTAA ACTGTGGAAA ACCTTTACCG ACTGCTTCAA CTGCCTGCCC 480

ATTGCTGCCA TTGTGGACGA GAAGATCTTC TGCTGCCACG GAGGCCTGTC CCCAGACTTG 540

CAATCCATGG AGCAGATTCG GCGTATCATG CGGCCCACAG ATGTGCCTGA CCAGGGCCTG 600

CTGTGTGACC TGCTGTGGTC TGACCCTGAC AAGGACGTGC AGGGCTGGGG CGAGAATGAC 660

CGTGGTGTCT CCTTTACCTT TGGGGCTGAG GTAGTGGCCA AGTTCCTGCA CAAGCACGAC 720

TTGGACCTCA TCTGCCGGGC GCACCAGGTG GTGGAAGATG GCTATGAGTT CTTTGCCAAG 780

CGGCAGCTGG TGACACTGTT CTCGGCTCCC AACTACTGTG GCGAGTTTGA CAACGCAGGC 840

GCCATGATGA GTGTCGATGA GACGCTCATG TGCTCCTTCC AGATCCTCAA GCCCGCTGAC 900

AAGAACAAGG GGAAATACGG GCAGTTCAGT GGCCTGAACC CTGGAGGCCG GCCCATCACC 960

CCACCCCGCA ACTCCGCCAA AGCCAAGAAG TAG 993

Domain Profile

S: 1     pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen  60

         p+kicgdihgqy+dllrlfeyggfppe+nylflgdyvdrgkqsleticlllaykikypen

Q: 58    PLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN  117

         89**********************************************************

S: 61    ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls  120

         ffllrgnhe+asinriygfydeckrryn+klwktftdcfnclp+aai+deki+c+hggls

Q: 118   FFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLS  177

         ************************************************************

S: 121   pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk  180

         pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv+gwgendrgvsftfga+vvakfl+

Q: 178   PDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLH  237

         ************************************************************

S: 181   khdldlicrahqvv  194

         khdldlicrahqvv

Q: 238   KHDLDLICRAHQVV  251

         *************8

Domain Sequence
(FASTA)

PLKICGDIHG QYYDLLRLFE YGGFPPESNY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60

FFLLRGNHEC ASINRIYGFY DECKRRYNIK LWKTFTDCFN CLPIAAIVDE KIFCCHGGLS 120

PDLQSMEQIR RIMRPTDVPD QGLLCDLLWS DPDKDVQGWG ENDRGVSFTF GAEVVAKFLH 180

KHDLDLICRA HQVV 194

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0072357	; C:PTW/PP1 phosphatase complex
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0048754	; P:branching morphogenesis of a tube
GO:0030324	; P:lung development
GO:0006470	; P:protein dephosphorylation

KEGG

aml:100464499

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013