EKS-AIM-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	364.8	3.0E-109	65	326	262

Status

Unreviewed

Ensembl Protein

ENSAMEP00000000878

UniProt Accession

G1L1X5;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000000822	ENSAMEP00000000878	ENSAMET00000000912

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEPE LSPSDVCPLA ESRAAGLEPV GHCEEMELTE TSVNQGPERI 60

GPHCFELLRV LGKGGYGKVF QVRKVQGTNL GKIYAMKVLR KAKIVRNAKD TAHTRAERNI 120

LESVKHPFIV ELAYAFQTGG KLYLILECLS GGELFTHLER EGIFLEDTAC FYLAEITLAL 180

GHLHSQGIIY RDLKPENIML NSQGHIKLTD FGLCKESIHE GAVTHTFCGT IEYMAPEILV 240

RSGHNRAVDW WSLGALMYDM LTGSPPFTAE NRKKTMDKII KGKLTLPPYL TPDARDLVKK 300

FLKRNPSQRI GGAPGDAADV QRHPFFRHIN WDDLLARRVD PPFRPSLQSE EDVSQFDTHF 360

TRQTPVDSPD DTALSESANQ AFLGFTYVAP SVLDSIKEGF SFQPKLRSPR RLNSSPRTPV 420

SPLKFSPFEG FRPSSGPLEP TEPSLPPLLP PPPPPPSSTA PLPIRPPSGT KKSKRGRGRP 480

GR 482

Nucleotide Sequence
(FASTA)

ATGGCGGCGG TGTTTGATCT GGACCTGGAG ACGGAGGAAG GCAGCGAGGG CGAGCCAGAG 60

TTGAGCCCCT CGGACGTGTG TCCCCTTGCC GAGTCGAGGG CGGCTGGCCT GGAGCCTGTG 120

GGACACTGTG AGGAGATGGA GCTCACTGAG ACCAGTGTGA ACCAGGGCCC TGAGCGCATC 180

GGGCCCCACT GCTTTGAGCT GCTGCGTGTG CTGGGCAAGG GGGGCTATGG CAAGGTGTTC 240

CAAGTGCGAA AGGTGCAAGG CACCAACTTG GGCAAAATAT ATGCCATGAA AGTCCTGAGG 300

AAGGCCAAAA TTGTGCGCAA CGCCAAGGAC ACAGCACACA CGCGGGCTGA ACGGAACATT 360

CTAGAGTCAG TGAAGCACCC CTTCATTGTG GAACTGGCCT ATGCCTTCCA GACTGGTGGC 420

AAACTCTACC TCATCCTCGA GTGCCTCAGT GGCGGTGAGC TCTTCACGCA TCTGGAGCGA 480

GAGGGCATCT TCCTGGAAGA CACGGCCTGT TTCTACCTGG CGGAGATCAC GCTGGCCCTG 540

GGCCATCTCC ACTCCCAAGG CATCATCTAC CGGGACCTCA AACCTGAGAA CATCATGCTT 600

AACAGCCAGG GCCACATCAA ACTGACAGAC TTTGGTCTGT GCAAGGAGTC GATCCACGAG 660

GGTGCCGTCA CCCACACTTT CTGTGGCACC ATTGAGTACA TGGCCCCTGA GATTCTGGTA 720

CGCAGCGGCC ACAACCGGGC AGTGGACTGG TGGAGCCTGG GGGCCCTGAT GTATGACATG 780

CTCACTGGAT CGCCACCCTT CACTGCGGAG AACCGGAAGA AAACCATGGA CAAGATCATC 840

AAAGGGAAGC TGACGCTGCC CCCCTACCTC ACCCCCGATG CCCGGGACCT TGTCAAAAAG 900

TTTCTGAAGC GGAATCCCAG CCAACGGATC GGGGGGGCCC CCGGGGATGC TGCTGATGTG 960

CAGAGGCACC CGTTCTTCCG GCACATTAAT TGGGATGACC TCCTGGCTCG CCGCGTAGAC 1020

CCCCCTTTCA GGCCCTCTCT GCAGTCAGAG GAGGACGTGA GCCAGTTTGA CACCCACTTC 1080

ACGCGGCAGA CGCCAGTGGA CAGTCCAGAT GATACGGCCC TCAGTGAGAG CGCAAACCAG 1140

GCCTTCCTGG GCTTCACATA CGTGGCACCC TCCGTCCTGG ACAGCATCAA GGAGGGCTTC 1200

TCCTTCCAGC CCAAGCTGCG CTCCCCCAGG CGCCTCAACA GCAGCCCCCG GACCCCGGTC 1260

AGCCCCCTGA AGTTCTCGCC CTTTGAGGGA TTCCGGCCCA GCTCTGGCCC ACTGGAGCCC 1320

ACGGAGCCCT CTCTACCTCC TCTCCTGCCG CCACCACCGC CACCACCCTC AAGCACTGCC 1380

CCGCTCCCCA TCCGACCCCC CTCAGGGACC AAGAAGTCTA AGAGGGGCCG TGGGCGCCCA 1440

GGCCGCTAG 1449

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 65    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  124

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 125   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  184

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 185   SQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  243

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l+lp +  l+++a+dlvk

Q: 244   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LTLPPY--LTPDARDLVK  299

         ****************************************..******..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 300   KFLKRNPSQRIGGapgDAADVQRHPFF  326

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL TLPPYLTPDA RDLVKKFLKR 240

NPSQRIGGAP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

aml:100464998

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013