EKS-AIM-00108

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00108

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	213.6	3.2E-63	494	639	146

Status

Unreviewed

Ensembl Protein

ENSAMEP00000000910

UniProt Accession

G1L205;

Protein Name

Protein Synonyms/Alias

Gene Name

MYLK3

Gene Synonyms/Alias

MYLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000000866	ENSAMEP00000000910	ENSAMET00000000947

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

639

Protein Sequence
(FASTA)

MSGASKEVLE TRGLPVSGKA CLTTMDKKLN VLNEKIDKLL HFQEDVTEKL QCVYQGMGHL 60

EQGLHRLEAS QILGPGGADR TPPAASQAGW PEVLELARAV RQDTAQQGAR LEALFRMVVA 120

VDKAIALVGA VFQNSKVVDF IMQGSVPWRK GSLADGPLEN KDRVEEKGAK PKHELSTRAV 180

QAEIRGPWEE SQKANLPEGT VERLTPVNAS EIGSDLPTQA EAPPRQEEGV PGPAQVPPGL 240

LPLPTEVEAK APGASAENPG TDLELSAASN RVSEAPTSQE ALPGTEQGSS FNRPDPQPSE 300

EGMRLTPGPL GLILGPLGLS PFVDSQPFCP RISIHVQETD TPGELLVTRG GSLRPTPPVE 360

APAAAHPAEK QIPKGASKIS ALRKRSTHEG AKAEEKQGPG AESTPGPSGA RTDNGDDAGA 420

PGEQQDKGVG AGNPEPRQDC TAGGVGRAEA GRTPLGAEAG SVVLDDSPAP PAPFEHRVVS 480

VKETSTSAGY TVCQHDVLGG GRFGQVHRCT EKSTGLSLAA KVIKVKSAKD REDVKNEVNI 540

MNQLSHVNLI QLYDAFESKN SFTLVMEYVD GGELFDRITE EKYQLTELDV ILFTKQICEG 600

VHYLHQHYIL HLDLKPENIL CVNQTGHQIK IIDFGLARR 639

Nucleotide Sequence
(FASTA)

ATGTCCGGAG CCTCCAAGGA GGTTCTGGAG ACCAGGGGGC TGCCGGTGTC AGGCAAGGCC 60

TGCTTAACCA CCATGGACAA AAAGCTGAAT GTGCTGAACG AGAAGATTGA CAAACTCTTG 120

CATTTCCAAG AAGATGTCAC GGAAAAACTG CAGTGTGTGT ACCAAGGGAT GGGCCACCTG 180

GAGCAAGGCC TGCACCGGCT GGAGGCCTCT CAGATTCTGG GCCCGGGTGG GGCTGACCGC 240

ACACCTCCAG CTGCCTCACA GGCTGGGTGG CCGGAGGTCC TGGAGCTGGC GAGGGCTGTG 300

CGGCAGGATA CCGCCCAGCA AGGCGCGAGG CTTGAAGCCC TGTTCAGGAT GGTAGTGGCC 360

GTGGACAAGG CCATCGCTTT GGTGGGGGCC GTGTTCCAGA ACTCGAAGGT GGTGGATTTC 420

ATCATGCAAG GGAGCGTCCC CTGGAGGAAA GGAAGCCTGG CTGACGGCCC TTTGGAGAAC 480

AAAGATCGAG TGGAAGAGAA AGGAGCAAAA CCAAAGCATG AGCTGAGTAC CAGAGCTGTG 540

CAAGCCGAGA TCAGGGGGCC CTGGGAAGAG AGCCAGAAGG CGAACCTGCC AGAGGGGACA 600

GTGGAGAGGC TGACCCCCGT CAATGCTTCA GAGATAGGAT CTGACCTCCC CACCCAGGCG 660

GAGGCCCCGC CACGGCAGGA AGAAGGAGTT CCTGGCCCAG CCCAAGTGCC CCCTGGCCTC 720

CTGCCGCTGC CCACAGAGGT GGAAGCCAAA GCTCCTGGAG CCTCCGCTGA GAACCCTGGG 780

ACTGACCTGG AACTGTCTGC AGCATCCAAC AGGGTCAGTG AGGCCCCCAC CAGCCAGGAG 840

GCTTTACCCG GTACAGAACA AGGATCGTCA TTCAACAGGC CTGACCCACA GCCCTCAGAG 900

GAAGGCATGA GGCTGACTCC AGGGCCCTTG GGCCTCATTT TGGGACCCCT GGGGCTTTCC 960

CCCTTTGTGG ACTCTCAGCC CTTCTGCCCC AGGATCTCCA TCCACGTGCA GGAGACGGAT 1020

ACCCCCGGGG AGCTGCTTGT GACCCGAGGG GGCAGCCTCA GACCCACGCC CCCCGTGGAG 1080

GCTCCAGCGG CTGCCCACCC AGCAGAAAAA CAGATCCCGA AAGGAGCCAG CAAGATTTCC 1140

GCCCTGCGGA AACGGAGCAC CCACGAGGGA GCAAAGGCAG AGGAGAAGCA GGGGCCTGGG 1200

GCCGAGTCCA CCCCGGGACC AAGCGGGGCC AGGACGGACA ACGGAGATGA TGCTGGAGCC 1260

CCGGGGGAGC AGCAGGACAA AGGCGTGGGA GCAGGAAACC CTGAGCCCCG GCAGGACTGC 1320

ACAGCCGGGG GTGTGGGCAG AGCTGAAGCA GGGAGGACAC CCCTTGGAGC CGAGGCAGGC 1380

AGCGTGGTTC TGGATGACAG CCCAGCCCCA CCCGCCCCCT TCGAGCACCG GGTGGTGAGC 1440

GTCAAGGAGA CCTCGACGTC GGCAGGGTAC ACAGTGTGCC AGCATGACGT CCTGGGAGGG 1500

GGCCGGTTCG GCCAGGTGCA CAGGTGCACG GAGAAGTCCA CAGGCCTCTC GCTGGCAGCC 1560

AAGGTCATCA AAGTGAAGAG CGCCAAGGAC CGGGAGGATG TGAAGAACGA GGTCAACATC 1620

ATGAACCAGC TCAGCCATGT GAACCTGATC CAGCTCTATG ACGCCTTTGA GAGCAAGAAC 1680

AGCTTTACCC TCGTCATGGA GTATGTGGAT GGGGGTGAAC TCTTTGACCG GATCACAGAG 1740

GAGAAGTACC AGCTGACCGA ACTGGATGTG ATCTTGTTCA CCAAGCAGAT CTGTGAGGGT 1800

GTGCATTACC TCCATCAACA CTACATCCTG CACCTGGACC TCAAGCCGGA GAACATACTG 1860

TGTGTCAATC AGACAGGACA TCAGATTAAG ATCATTGACT TTGGGCTGGC GAGAAGGTAA 1920

Domain Profile

S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62

         +++ lg G+fg+v++++ekstg +laak++kv+++kd+e+vk+E++i+nql+H +liqly

Q: 494   QHDVLGGGRFGQVHRCTEKSTGLSLAAKVIKVKSAKDREDVKNEVNIMNQLSHVNLIQLY  553

         6789********************************************************

S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122

         dafesk++++lv+E+v+ggelf+ri+ee+y+ltE +v+lf++q++e+++ylH+++i+Hld

Q: 554   DAFESKNSFTLVMEYVDGGELFDRITEEKYQLTELDVILFTKQICEGVHYLHQHYILHLD  613

         ************************************************************

S: 123   lkpenillqskkskqiKlidFGlark  148

         lkpenil+++++++qiK+idFGlar+

Q: 614   LKPENILCVNQTGHQIKIIDFGLARR  639

         ************************98

Domain Sequence
(FASTA)

QHDVLGGGRF GQVHRCTEKS TGLSLAAKVI KVKSAKDRED VKNEVNIMNQ LSHVNLIQLY 60

DAFESKNSFT LVMEYVDGGE LFDRITEEKY QLTELDVILF TKQICEGVHY LHQHYILHLD 120

LKPENILCVN QTGHQIKIID FGLARR 146

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity
GO:0004687	; F:myosin light chain kinase activity
GO:0071347	; P:cellular response to interleukin-1
GO:0002528	; P:regulation of vascular permeability involved in acute inflammatory response
GO:0045214	; P:sarcomere organization

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013