EKS-AIM-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	366.5	8.9E-110	46	330	285

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001304

UniProt Accession

G1L344;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001223	ENSAMEP00000001304	ENSAMET00000001356

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

367

Protein Sequence
(FASTA)

RERPALGMGD TESESEQIRL KCIRKDGFFT VPPEHRLGRC RSVKEFEKLN RIGEGTYGIV 60

YRARDTQTDE IVALKKVRMD KEKDGVPISS LREITLLLRL RHPNIVELKE VVVGNHLESI 120

FLVMGYCEQD LASLLENMPT PFSEAQVKCI VLQVLRGLQY LHQNFIIHRD LKVSNLLMTD 180

KGCVKTADFG LARAYGIPVK PMTPKVVTLW YRAPELLLGT TTQTTSIDMW AMGCILAELL 240

AHKPLLPGTS EIHQVDLIVQ LLGTPSENIW PGFSRLPLVG QYSLRKQPYN NLKHKFPWLS 300

EAGLRLLNFL FMYDPKKRAT ATDGLESSYF KEKPLPCEPE LMPTFPHHRN KRAVPATSEG 360

QGKRCKP 367

Nucleotide Sequence
(FASTA)

CGTGAGCGGC CTGCGCTCGG CATGGGGGAC ACGGAGTCCG AGTCGGAGCA GATCCGTCTG 60

AAGTGTATCC GTAAGGACGG CTTCTTCACG GTGCCTCCGG AACACAGGCT GGGACGGTGT 120

CGGAGTGTGA AGGAGTTTGA GAAGCTGAAC CGCATCGGGG AAGGCACCTA TGGCATTGTG 180

TATCGGGCCC GGGACACCCA GACAGATGAG ATTGTTGCCC TGAAGAAAGT GCGGATGGAC 240

AAGGAGAAGG ATGGGGTCCC CATCAGCAGC CTTCGAGAGA TCACACTGCT CCTTCGCCTT 300

CGACATCCAA ATATCGTGGA GCTAAAGGAA GTGGTTGTTG GGAACCACCT GGAGAGCATC 360

TTTCTGGTGA TGGGTTATTG TGAGCAAGAT CTGGCCAGCC TTCTGGAGAA CATGCCGACA 420

CCCTTCTCTG AGGCCCAGGT CAAGTGCATT GTGCTGCAGG TACTCCGAGG CCTTCAGTAC 480

CTGCACCAGA ACTTCATCAT CCACAGGGAC CTGAAGGTGT CCAACTTGCT CATGACCGAT 540

AAGGGCTGTG TGAAGACAGC GGATTTCGGC CTGGCCCGGG CCTATGGCAT TCCAGTGAAG 600

CCAATGACCC CCAAGGTGGT CACACTCTGG TACCGAGCCC CCGAACTGCT TTTGGGAACC 660

ACCACTCAGA CCACAAGCAT CGACATGTGG GCCATGGGCT GCATCCTGGC CGAGCTGCTG 720

GCCCACAAGC CCCTTCTCCC CGGCACATCC GAGATCCACC AGGTGGACCT GATTGTGCAG 780

CTGCTGGGGA CGCCCAGTGA GAACATCTGG CCGGGTTTCT CCAGGCTCCC ACTGGTGGGT 840

CAGTACAGCC TCAGGAAGCA GCCCTACAAC AACCTCAAAC ACAAGTTCCC GTGGCTCTCA 900

GAGGCTGGCC TGCGCCTGCT CAACTTCCTC TTCATGTACG ACCCCAAGAA AAGGGCAACG 960

GCTACAGACG GCTTGGAGAG CTCCTACTTC AAGGAGAAGC CCTTGCCCTG TGAGCCGGAG 1020

CTCATGCCTA CCTTCCCCCA CCACCGCAAC AAGCGGGCCG TCCCGGCCAC GTCTGAGGGC 1080

CAGGGCAAGC GCTGTAAGCC CTGA 1104

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+gvpi++lrEi+ll +l+h+ni

Q: 46    FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNI  105

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 106   VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQVLRGLQYLHQN  164

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara++ p+k +t++vvTlwYraPelLlg+++ +

Q: 165   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQT  224

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W++gcilaell++kpl++g+sei+q++ i++llgtpse++wp++s+lp +  +s+

Q: 225   TSIDMWAMGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSRLPLVGqYSL  284

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +a++ l+++yf

Q: 285   RKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATATDGLESSYF  330

         ********************************************98

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TQTDEIVALK KVRMDKEKDG VPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQVL RGLQYLHQNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GIPVKPMTPK VVTLWYRAPE LLLGTTTQTT 180

SIDMWAMGCI LAELLAHKPL LPGTSEIHQV DLIVQLLGTP SENIWPGFSR LPLVGQYSLR 240

KQPYNNLKHK FPWLSEAGLR LLNFLFMYDP KKRATATDGL ESSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013