EKS-AIM-00115

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00115

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	479.6	2.5E-144	1050	1310	261

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001397

UniProt Accession

D2H6R5;

Protein Name

Protein Synonyms/Alias

Putative uncharacterized protein;

Gene Name

MET

Gene Synonyms/Alias

PANDA_005689;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001314	ENSAMEP00000001400	ENSAMET00000001453
ENSAMEG00000001314	ENSAMEP00000001397	ENSAMET00000001450

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1353

Protein Sequence
(FASTA)

MKASAVIAPG ILVLLFTLVH KSYGECKEAL VKSEMNVNMK YQLPNFTAET PIQNVVLHKH 60

HIYLGAVNYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD CSHRANLSGG IWEDNINMAL 120

VIDTYYDDQL ISCGSVHRGT CQRHVLPPSN TADIQSEVHC MYSPQADEEP GQCPDCVVSA 180

LGTKVLISEK DRFINFFVGN TINSSYHPDH LLHSISVRRL KETQDGFKFL TDQSYIDVLP 240

EFRDSYPIKY VHAFESNHFI YFLTVQRETL DAQTFHTRII RFCSVDSGLH SYMEMPPGAH 300

LAKQIGANLN DDILYGVFAR SKPDSTEPMN RSAVCAFPIK YVNEFFNKIV NKNNVRCLQH 360

FYGPNHEHCF NRTLLRNSSG CEVRSDEYRT EFTTALQRVD LFMGQFNQVL LTSISTFIKG 420

DLTIANLGTS EGRFMQVVVS RSGSSTPHVN FRLDSHPVSP EAIVEHPLNQ NGYTLVVTGK 480

KITKIPLNGL GCEHFQSCSQ CLSAPPFVQC GWCHDKCVLL EECPTGTWTQ EICLPTIYEV 540

SPTSAPLEGG TMLTVCGWDF GFRRNNKFDL KKTKVLLGND SCTLTLSEST TNMLKCTVGP 600

AVNEHFNISI IIANGRGTAQ YSAFSYVDPI ITSISPSYGP KTGGTLLTLT GKYLNSGNSR 660

HISIGGKTCT LKSVSDSILE CYTPAQTTPT EFPIKLKIDL ANREMNSFSY QEDPIVYAIH 720

PTKSFISGGS TITAVGKNLH SVSVLRMVIN VPEARRNFTV ACRHRSNSEI ICCTTPSLQQ 780

LNLQLPLKTK AFFMLDGIHS KYFDLIYVHN PVFKPFEKPV MISIGNENVL EIKGNDIDPE 840

AVKGEVLKVG NKSCETIYSD SEAVLCKVPN DLLKLNNELN IEWKQAVSST VLGKVIVQPD 900

QNFTGLIVGV ISISLILLLL LGLFLWLKRR KQIKDLGSEL VRYDARVHTP HLDRLVSARS 960

VSPTTEMVSN ESVDYRATFP EDQFPNSSQN GSCRQVQYPL TDLSPMLTSG DSDISSPLLQ 1020

NTVHIDLSAL NPELVQAVQH VVIGPSSLIV HFNEVIGRGH FGCVYHGTLL DNDDKKIHCA 1080

VKSLNRITDI GEVSQFLTEG IIMKDFSHPN VLSLLGICLR SEGSPLVVLP YMKHGDLRNF 1140

IRNETHNPTV KDLIGFGLQV AKGMKYLASK KFVHRDLAAR NCMLDEKFTV KVADFGLARD 1200

MYDKEYYSVH NKTGAKLPVK WMALESLQTQ KFTTKSDVWS FGVLLWELMT RGAPPYPDVN 1260

TFDITVYLLQ GRRLLQPEYC PDPLYEVMLK CWHPKAELRP SFSELVSRIS AIFSTFIGEH 1320

YVHVNATYVN VKCVAPYPSL LSSQDNIDGE GDT 1353

Nucleotide Sequence
(FASTA)

ATGAAGGCCT CTGCTGTGAT TGCACCTGGC ATCCTTGTAC TTCTGTTTAC CTTGGTGCAC 60

AAGAGCTATG GGGAGTGCAA AGAGGCACTA GTAAAGTCTG AGATGAATGT GAACATGAAG 120

TATCAGCTTC CCAACTTCAC TGCAGAAACA CCCATCCAGA ATGTTGTTTT ACACAAGCAT 180

CATATTTACC TCGGTGCAGT TAACTATATT TACGTTTTAA ATGACAAAGA CCTTCAGAAA 240

GTTGCTGAGT ACAAGACTGG GCCTGTGCTG GAACACCCAG ATTGTTTCCC ATGTCAGGAC 300

TGCAGCCACA GAGCCAATTT ATCAGGTGGC ATTTGGGAAG ATAACATCAA CATGGCTCTA 360

GTTATTGACA CCTACTATGA TGACCAACTC ATTAGCTGTG GCAGTGTCCA CAGAGGGACC 420

TGCCAGCGAC ATGTCCTTCC ACCCAGCAAT ACTGCTGATA TACAGTCGGA AGTTCATTGC 480

ATGTACTCCC CACAGGCAGA CGAAGAGCCC GGCCAGTGCC CTGACTGTGT GGTGAGTGCC 540

CTGGGAACCA AAGTCCTGAT ATCTGAAAAG GATCGGTTCA TCAACTTCTT CGTGGGTAAC 600

ACCATAAATT CCTCGTACCA TCCAGATCAT TTATTGCATT CAATATCAGT GAGAAGGCTA 660

AAGGAAACGC AAGATGGTTT CAAGTTTTTG ACAGACCAAT CTTATATTGA CGTTCTACCT 720

GAGTTCAGAG ATTCCTACCC TATTAAATAT GTCCACGCCT TTGAAAGCAA TCATTTTATT 780

TACTTTTTGA CAGTCCAACG AGAAACTCTA GATGCTCAGA CTTTTCACAC AAGAATAATC 840

AGGTTCTGTT CTGTAGACTC CGGATTGCAT TCCTACATGG AAATGCCTCC TGGGGCCCAC 900

CTTGCTAAGC AAATAGGTGC CAACCTGAAT GATGACATTC TCTACGGAGT GTTTGCACGA 960

AGCAAGCCAG ATTCTACTGA ACCCATGAAT CGTTCTGCCG TCTGTGCATT CCCTATCAAA 1020

TATGTCAACG AATTCTTCAA CAAGATCGTC AACAAAAACA ATGTGAGATG TCTTCAACAT 1080

TTTTATGGAC CCAACCACGA ACACTGCTTT AACAGGACAC TTTTGAGAAA TTCATCAGGC 1140

TGTGAAGTGC GCAGTGACGA ATATCGAACG GAGTTTACCA CAGCTTTGCA GCGTGTTGAC 1200

TTATTCATGG GCCAATTCAA CCAAGTCCTC TTAACATCTA TATCTACCTT CATTAAAGGA 1260

GACCTCACCA TTGCTAATCT TGGGACGTCA GAGGGTCGTT TCATGCAGGT TGTGGTTTCT 1320

CGATCAGGAT CGTCAACCCC TCATGTGAAT TTTCGCCTGG ATTCCCACCC TGTGTCTCCA 1380

GAAGCAATTG TGGAGCACCC TTTAAACCAA AATGGCTACA CACTGGTCGT CACTGGGAAG 1440

AAAATCACCA AGATCCCACT GAATGGCTTA GGCTGTGAAC ATTTCCAGTC CTGCAGTCAG 1500

TGTCTCTCCG CCCCTCCCTT TGTGCAGTGT GGCTGGTGCC ATGACAAATG TGTGCTATTG 1560

GAGGAATGCC CCACTGGAAC ATGGACTCAG GAGATCTGTC TGCCTACAAT CTATGAGGTT 1620

TCCCCAACTA GTGCACCCTT GGAAGGAGGG ACAATGCTGA CCGTATGTGG CTGGGACTTT 1680

GGATTCAGGA GGAATAATAA ATTTGATTTA AAGAAAACCA AAGTTCTCCT TGGAAATGAC 1740

AGCTGCACCT TGACCTTAAG TGAGAGCACA ACAAATATGC TGAAATGCAC AGTTGGTCCT 1800

GCAGTGAATG AGCATTTCAA TATATCCATA ATTATTGCAA ATGGTCGAGG GACAGCACAA 1860

TATAGTGCAT TTTCCTATGT GGATCCTATA ATAACAAGTA TTTCTCCAAG TTATGGTCCT 1920

AAGACTGGCG GCACCTTGCT TACTTTAACT GGAAAGTACC TAAACAGTGG GAATTCTAGA 1980

CACATTTCAA TTGGTGGAAA AACATGTACT TTAAAAAGTG TGTCAGATAG TATTCTCGAA 2040

TGTTATACCC CAGCTCAAAC CACTCCAACT GAGTTCCCTA TTAAATTGAA AATTGACTTA 2100

GCCAACCGAG AGATGAACAG CTTCAGTTAC CAGGAAGACC CCATTGTCTA TGCAATTCAT 2160

CCAACCAAAT CTTTTATTAG TGGTGGGAGC ACAATAACAG CTGTTGGAAA AAACCTGCAT 2220

TCAGTTAGTG TCCTGAGGAT GGTAATAAAT GTACCTGAAG CAAGAAGGAA CTTTACAGTG 2280

GCATGTCGAC ATCGCTCTAA TTCAGAGATA ATCTGCTGTA CAACTCCTTC ACTGCAACAG 2340

CTGAATCTGC AACTCCCTCT GAAAACCAAA GCCTTTTTCA TGTTAGATGG GATCCATTCC 2400

AAATACTTTG ATCTCATTTA TGTACATAAT CCTGTGTTTA AGCCTTTTGA AAAGCCAGTG 2460

ATGATCTCAA TAGGCAATGA AAATGTACTG GAAATTAAGG GAAATGATAT TGACCCTGAA 2520

GCAGTTAAAG GTGAAGTGTT AAAAGTTGGA AATAAGAGCT GTGAGACTAT ATACTCAGAT 2580

TCTGAAGCCG TTTTATGCAA GGTCCCCAAT GACCTGCTGA AATTGAACAA CGAGCTAAAT 2640

ATAGAGTGGA AGCAAGCAGT TTCTTCAACC GTCCTTGGAA AAGTAATTGT TCAACCAGAT 2700

CAGAACTTCA CAGGATTGAT TGTTGGTGTT ATCTCAATAT CATTAATACT CTTATTATTA 2760

CTCGGGCTTT TCCTGTGGCT GAAAAGGAGA AAGCAAATTA AAGATCTGGG CAGTGAATTA 2820

GTTCGCTATG ATGCAAGAGT ACACACTCCT CATTTGGATA GGCTTGTAAG TGCCCGAAGT 2880

GTAAGCCCAA CTACAGAAAT GGTTTCAAAT GAATCTGTAG ACTACCGAGC TACTTTTCCA 2940

GAAGACCAGT TTCCTAACTC ATCTCAGAAT GGATCATGCA GACAAGTTCA GTATCCTCTG 3000

ACAGACCTGT CCCCCATGCT TACCAGTGGG GACTCTGATA TATCCAGTCC ATTATTGCAA 3060

AATACTGTCC ACATTGACCT CAGTGCTCTA AATCCAGAGC TGGTCCAGGC AGTCCAGCAC 3120

GTAGTGATTG GGCCGAGTAG CCTAATTGTG CATTTCAATG AAGTCATAGG AAGAGGACAT 3180

TTTGGGTGCG TATACCATGG GACTTTGCTG GACAATGATG ACAAGAAAAT TCACTGTGCT 3240

GTGAAATCTT TGAATCGAAT CACTGACATA GGAGAAGTTT CCCAGTTTCT GACTGAGGGA 3300

ATCATCATGA AAGATTTTAG TCATCCAAAT GTTCTCTCAC TCTTGGGAAT CTGCCTTCGA 3360

AGTGAGGGGT CTCCGCTGGT AGTCCTACCA TACATGAAAC ATGGAGATCT TCGAAATTTC 3420

ATTAGGAATG AGACTCATAA CCCAACTGTA AAAGATCTTA TTGGCTTTGG TCTTCAAGTA 3480

GCCAAAGGCA TGAAATATCT TGCAAGCAAA AAGTTTGTCC ACAGAGACTT GGCTGCAAGA 3540

AACTGTATGC TGGATGAAAA ATTCACTGTC AAGGTTGCTG ATTTTGGTCT TGCCAGAGAC 3600

ATGTATGATA AAGAATACTA TAGTGTACAC AACAAAACAG GTGCCAAGCT GCCCGTGAAG 3660

TGGATGGCTT TAGAAAGTCT GCAAACTCAG AAGTTTACCA CCAAGTCAGA TGTGTGGTCC 3720

TTTGGCGTGC TCCTCTGGGA ACTGATGACA AGAGGAGCAC CACCTTATCC TGACGTCAAC 3780

ACCTTTGATA TAACAGTTTA CTTGTTGCAA GGCAGAAGGC TCCTACAACC CGAATACTGC 3840

CCAGATCCCT TATATGAAGT GATGCTCAAA TGCTGGCACC CTAAAGCTGA ACTGCGGCCA 3900

TCTTTTTCTG AACTGGTCTC CAGGATATCA GCAATATTCT CTACTTTCAT TGGAGAGCAC 3960

TATGTCCATG TGAACGCTAC TTATGTGAAT GTCAAATGTG TGGCTCCATA CCCTTCTCTA 4020

TTGTCATCAC AAGATAACAT TGATGGCGAG GGGGACACAT GA 4062

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1050  VHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1109

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1110  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1169

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1170  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1229

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1230  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1288

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k++ rp+fs+lvs+is

Q: 1289  LKCWHPKAELRPSFSELVSRIS  1310

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDDKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAELR PSFSELVSRI S 261

Keyword

ATP-binding; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013