EPS-AIM-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	168.1	3.3E-49	314	500	187

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001536

UniProt Accession

D2GXL3;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1G

Gene Synonyms/Alias

PPM1G; PANDA_001647;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001433	ENSAMEP00000001536	ENSAMET00000001595

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

544

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGVGA SRLTLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGAPH SKSGAGTGEE 180

PGSQGLNGEA GPEDPSRETS SEENGPTAKA HTGLSSNSER GTEAGQGGEP GTPTGEAGPS 240

CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300

AEEDEEEEEM MVPGMEGKEE PGSDSGTTAV VALIRGKQLI VANAGDSRCV VSEAGKALDM 360

SYDHKPEDEV ELARIKNAGG KVTMDGRVNG GLNLSRAIGD HFYKRNKNLP PEEQMISALP 420

DIKVLTLTDD HEFMVIACDG IWNVMSSQEV IDFIQSKISQ RDENGELRLL SSIVEELLDQ 480

CLAPDTSGDG TGCDNMTCII ICFKPRNTAE LQPESGKRKL EEVLSSEGAE ENGNSDNKKK 540

AKRD 544

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 60

TCGCGCCTGA CGCTGCCCTA CGGCTTCTCC GCCATGCAGG GTTGGCGCGT CTCCATGGAG 120

GATGCTCACA ACTGTATTCC TGAGTTGGAC AGTGAGACAG CCATGTTTTC TGTCTATGAT 180

GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 240

GATCAGAAGG CCTACAAAGA AGGCAAGCTA CAAAAGGCAT TAGAAGATGC CTTCTTGGCT 300

ATCGATGCCA AACTGACCAC TGAGGAAGTC ATCAAGGAGC TGGCACAGAT TGCAGGGCGA 360

CCCACTGAGG ATGAGGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 420

GAGGCTGCAC TGCTGCATGA AGAGGCCACC ATGACTATTG AAGAGCTGCT GACACGCTAC 480

GGGCAGAACT GTCACAAGGG TGCTCCCCAC AGCAAATCTG GAGCTGGGAC AGGCGAGGAA 540

CCAGGGTCCC AGGGCCTCAA CGGGGAGGCA GGACCTGAGG ACCCATCTCG GGAAACTTCT 600

TCAGAGGAAA ATGGCCCCAC AGCCAAGGCC CACACAGGCC TTTCCTCCAA CTCAGAACGT 660

GGGACTGAGG CAGGCCAAGG TGGTGAGCCT GGCACTCCCA CTGGTGAGGC TGGGCCTTCC 720

TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CGAAGTTCTT TGAGGACAGT 780

GAGGATGAGT CAGATGAGGC AGAGGAGGAA GAGGAAGACA GTGAGGAATG CAGTGAGGAA 840

GAGGATGGCT ACAGCAGCGA AGAGGCAGAG AATGAGGAAG ACGAGGATGA CACTGAGGAG 900

GCTGAAGAGG ATGAGGAAGA AGAAGAGATG ATGGTGCCAG GCATGGAAGG CAAGGAGGAG 960

CCTGGCTCTG ACAGCGGTAC AACTGCGGTG GTGGCTCTGA TACGAGGGAA GCAGTTGATT 1020

GTAGCCAATG CAGGAGACTC TCGTTGTGTG GTGTCCGAGG CTGGCAAAGC TTTGGACATG 1080

TCCTATGACC ACAAACCGGA GGATGAAGTG GAGCTAGCAC GCATCAAGAA TGCTGGTGGC 1140

AAGGTCACCA TGGATGGGCG AGTCAACGGG GGCCTCAACC TCTCCAGAGC CATTGGAGAC 1200

CACTTCTACA AGAGAAATAA GAACTTGCCA CCTGAGGAAC AGATGATTTC AGCCCTTCCT 1260

GACATCAAGG TGCTGACTCT CACTGACGAC CACGAATTCA TGGTTATTGC CTGTGATGGC 1320

ATATGGAATG TGATGAGCAG CCAGGAAGTT ATAGACTTTA TTCAATCAAA AATCAGCCAG 1380

CGTGATGAAA ATGGGGAGCT TCGGTTATTG TCATCCATTG TGGAAGAGCT GCTGGATCAG 1440

TGCCTGGCAC CAGACACTTC TGGGGACGGT ACAGGGTGTG ACAACATGAC CTGCATCATC 1500

ATTTGCTTCA AGCCCCGAAA CACAGCAGAG CTTCAGCCAG AGAGTGGCAA GCGGAAACTG 1560

GAGGAGGTGC TCTCTTCTGA AGGGGCTGAA GAAAATGGCA ACAGTGACAA TAAGAAGAAG 1620

GCCAAGCGGG ACTAA 1635

Domain Profile

S: 92    vleeksldidksGstavvalikdsklyvanvGdSravLcrngkavelssdHkpsredEle  151

          +e k++  + sG+tavvali++++l+van+GdSr+v +  gka+ +s dHkp+ e El+

Q: 314   GMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELA  373

         23444444555*************************************************

S: 152   RieeaggsvilkdgaRvlGvLavsRalGdlylk.........pyvtpePevtshrltsed  202

         Ri++agg+v+ +   Rv+G L++sRa+Gd ++k         +++++ P++ + +lt ++

Q: 374   RIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDDH  431

         ************9..*********************************************

S: 203   efliLasDGlwdvvsneeavslvrdvle......kkeaeqeaakkLvklalargsk....  252

         ef+++a+DG+w+v+s++e+++++++ ++      + + ++++ ++L++++la  ++

Q: 432   EFMVIACDGIWNVMSSQEVIDFIQSKISqrdengELRLLSSIVEELLDQCLAPDTSgdgt  491

         *************************99988776666677889999999999999987777

S: 253   ..dnvsaiv  259

           dn++ i+

Q: 492   gcDNMTCII  500

777777766

Domain Sequence
(FASTA)

GMEGKEEPGS DSGTTAVVAL IRGKQLIVAN AGDSRCVVSE AGKALDMSYD HKPEDEVELA 60

RIKNAGGKVT MDGRVNGGLN LSRAIGDHFY KRNKNLPPEE QMISALPDIK VLTLTDDHEF 120

MVIACDGIWN VMSSQEVIDF IQSKISQRDE NGELRLLSSI VEELLDQCLA PDTSGDGTGC 180

DNMTCII 187

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

aml:100464390

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013