EKS-AIM-00229

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00229

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	328.0	3.5E-98	79	329	251

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001519

UniProt Accession

G1L3Q9;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK2

Gene Synonyms/Alias

NUAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001435	ENSAMEP00000001519	ENSAMET00000001576

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

654

Protein Sequence
(FASTA)

APRPGCGSCT PGSSCPRAAG FPSTLARLLP AMEPSAFPRR PGPAPSSAPA LTAELARPLT 60

DGLIKPKPHH HKHNLRHRYE FLETLGKGTY GKVKKARESS GRLVAIKSIR KDKIKDEQDL 120

MHIRREIEIM SSLNHPHIIA IHEVFENSSK IVIVMEYASR GDLYDYISER QRLSEQDARH 180

FFRQIVSAVH YCHQNGVVHR DLKLENILLD ANGNIKIADF GLSNLYHQGK FLQTFCGSPL 240

YASPEIVNGK PYTGPEVDSW SLGVLLYILV HGTMPFDGQD HKTLVRQISH GSYREPPKPS 300

DACGLIRWLL MVNPTRRATL EDVASHWWVN WGYATHVGER EALQEEGHPG SNSGRASMAD 360

WLRRSSPPPP RNGAKVCSFF KQHTPGGGSV APGLERQHSL KKSRKENDMA QSLQGDLADD 420

PSLRPARGNL KLPKGILKKK APPLLEGARE DPEPSPGPAD PGQAAPLLPK KGILKKSRQR 480

ESGYYSSPEP SESGELLDAG DVFVSGDSEE QKPPQAPGLP LHRKGILKHN GKFSCTALEH 540

TAPTTFGSLD ELASPHPLAR ASRPSGAMSE DSILSSESFD QLDLPERLPE PLLRGCVSVD 600

NLMGLEEPPT DGPGSRGLRR WRQDPLGDSC FSLTDCQEVT EAYRQALGVC SKLS 654

Nucleotide Sequence
(FASTA)

GCTCCCCGCC CCGGGTGCGG GTCTTGTACC CCGGGCTCTA GCTGTCCCCG CGCAGCCGGC 60

TTCCCCTCCA CCCTCGCTCG CCTCCTGCCC GCCATGGAGC CGTCGGCTTT CCCCCGGCGC 120

CCCGGCCCGG CTCCCTCTAG CGCCCCCGCC CTGACCGCCG AGCTCGCCCG GCCCCTGACC 180

GACGGGCTCA TCAAGCCAAA GCCCCACCAC CACAAGCACA ACCTGCGCCA CCGCTACGAG 240

TTCCTCGAGA CCCTGGGCAA GGGCACCTAC GGGAAGGTGA AGAAGGCGCG GGAGAGCTCG 300

GGGCGCTTGG TGGCCATCAA GTCAATCCGG AAAGACAAAA TCAAAGACGA GCAAGACCTG 360

ATGCACATTC GACGAGAGAT TGAGATCATG TCGTCACTCA ACCATCCCCA CATCATTGCC 420

ATCCACGAAG TGTTTGAGAA CAGCAGCAAG ATTGTCATTG TCATGGAGTA TGCCAGCCGG 480

GGTGACCTGT ACGACTACAT CAGCGAGCGG CAGCGGCTCA GCGAGCAGGA CGCCCGCCAC 540

TTCTTCCGAC AGATCGTCTC CGCCGTGCAC TACTGCCACC AGAATGGGGT TGTCCACCGG 600

GATCTCAAGC TGGAGAACAT CCTCTTAGAT GCCAATGGAA ATATTAAGAT TGCGGACTTC 660

GGGCTCTCCA ACCTCTACCA CCAGGGCAAG TTCCTGCAGA CGTTCTGCGG GAGCCCCCTG 720

TACGCCTCGC CCGAGATCGT CAACGGGAAG CCCTACACGG GCCCAGAGGT GGACAGCTGG 780

TCCCTGGGTG TCCTTCTATA CATCCTGGTG CATGGCACCA TGCCCTTTGA TGGGCAGGAC 840

CACAAGACAC TGGTGAGACA GATCAGCCAC GGCTCCTACC GGGAGCCGCC TAAACCCTCC 900

GATGCCTGTG GCCTGATCCG GTGGCTATTA ATGGTGAACC CCACCCGCCG AGCCACCCTC 960

GAGGATGTGG CCAGTCACTG GTGGGTCAAC TGGGGCTATG CCACCCATGT GGGGGAGCGG 1020

GAGGCTCTGC AGGAGGAAGG GCACCCTGGC AGCAACTCTG GCCGCGCCTC CATGGCCGAC 1080

TGGCTCCGGC GCTCCTCCCC CCCTCCCCCG CGGAACGGGG CCAAGGTCTG CAGCTTCTTC 1140

AAGCAGCACA CGCCCGGAGG TGGGAGCGTC GCCCCAGGCC TGGAGCGCCA GCATTCGCTG 1200

AAGAAGTCCC GCAAAGAGAA CGACATGGCC CAGTCTCTCC AGGGCGACCT GGCGGACGAC 1260

CCCTCCCTTC GCCCTGCCAG GGGCAACCTC AAGCTACCCA AGGGCATTCT CAAGAAGAAG 1320

GCACCGCCCT TGTTGGAAGG GGCCAGGGAA GACCCTGAGC CCAGCCCAGG CCCTGCGGAC 1380

CCAGGACAGG CTGCCCCCCT GCTCCCCAAG AAGGGCATCC TCAAGAAGTC TCGGCAGCGG 1440

GAATCTGGCT ACTACTCCTC TCCTGAACCC AGTGAGTCTG GGGAGCTCCT GGATGCAGGG 1500

GACGTGTTCG TGAGTGGAGA CTCTGAGGAG CAGAAGCCCC CGCAAGCCCC AGGGCTGCCC 1560

CTGCATCGCA AAGGCATCCT CAAACACAAT GGCAAGTTCT CCTGCACGGC CCTGGAGCAC 1620

ACAGCCCCCA CCACCTTCGG CTCCTTGGAT GAACTGGCCT CCCCTCACCC CCTGGCCCGG 1680

GCCAGCCGCC CCTCAGGGGC TATGAGTGAG GACAGCATAC TGTCCTCTGA GTCATTCGAC 1740

CAGCTGGACT TGCCTGAGCG GCTCCCTGAG CCCCTGCTGC GGGGCTGTGT GTCTGTGGAC 1800

AACCTCATGG GGCTTGAGGA GCCCCCCACA GATGGCCCTG GAAGCAGGGG CCTGAGGCGC 1860

TGGCGGCAGG ACCCTCTGGG GGATAGCTGC TTTTCCCTGA CAGACTGCCA GGAGGTGACA 1920

GAGGCCTACC GACAGGCACT GGGGGTCTGC TCAAAGCTCA GCTGA 1965

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y++l+tlG+g++gkVk+a+++  ++ va+K i+k+k+ +e+ l +i+rEiei+++l+hp+

Q: 79    YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIkDEQDLMHIRREIEIMSSLNHPH  137

         99***************9986.799**********996778899****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii ++ev+e+++k+++v+eyas+g+L+dyi+e++rl+e++ar++f+q+vsav+Y+h++g+

Q: 138   IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQRLSEQDARHFFRQIVSAVHYCHQNGV  197

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld+++nikiaDFGl+nl+++gk l+tfcGsp Ya+Pe+++gk+Y+gp+v

Q: 198   VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV  257

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D WslGv+Ly+lv g++Pfd+++ k+l+++i++g+++ p k s ++  L+r lL+v+p++

Q: 258   DSWSLGVLLYILVHGTMPFDGQDHKTLVRQISHGSYREPPKPS-DACGLIRWLLMVNPTR  316

         ****************************************966.5668************

S: 240   Ratieeilkhewl  252

         Rat+e++ +h w+

Q: 317   RATLEDVASHWWV  329

         ************6

Domain Sequence
(FASTA)

YEFLETLGKG TYGKVKKARE SSGRLVAIKS IRKDKIKDEQ DLMHIRREIE IMSSLNHPHI 60

IAIHEVFENS SKIVIVMEYA SRGDLYDYIS ERQRLSEQDA RHFFRQIVSA VHYCHQNGVV 120

HRDLKLENIL LDANGNIKIA DFGLSNLYHQ GKFLQTFCGS PLYASPEIVN GKPYTGPEVD 180

SWSLGVLLYI LVHGTMPFDG QDHKTLVRQI SHGSYREPPK PSDACGLIRW LLMVNPTRRA 240

TLEDVASHWW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0042149	; P:cellular response to glucose starvation
GO:0043066	; P:negative regulation of apoptotic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013