EKS-AIM-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	379.2	1.2E-113	175	456	282

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001597

UniProt Accession

G1L3Y7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001476	ENSAMEP00000001597	ENSAMET00000001658

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

LTMNKMKSFK RRLSLSVPRT ETIEESLAEF TEQFNQLHNR HTEDLQLGPL GRDPQPESST 60

FSPTDSGEDP GQPSPGLQYR RQSQRRFSME VRGSGLSPGG GWGCGRTHRW VCARGGWLPT 120

LQDTSKRLSL PMDIRLPQEF LQKLQLESPD LPKPLSRMSR RASLSDIGFG KLETYVKLDK 180

LGEGTYATVF KGRSKLTENL VALKEIRLEH EEGAPCTAIR EVSLLKNLKH ANIVTLHDLI 240

HTERSLTLVF EYLDSDLKQY LDQCGRLVSM HNVKIFMFQL LRGLAYCHRR KILHRDLKPQ 300

NLLISERGEL KLADFGLARA KSVPTKTYSN EVVTLWYRPP DVLLGSTEYS TPIDMWGVGC 360

IHYEMATGRP LFPGSTVKEE LHLIFRLLGT PTEETWPGVM ALSEFRAYNF PRYLPQPLIS 420

HAPRLDTDGI HLLTNLLLYE SKSRMAAEAA LNHPYFRSLG ERVHQLEDTA SIFSLKEIQL 480

QKDPGYRGLA FQQPGRGKSR RQSIF 505

Nucleotide Sequence
(FASTA)

CTGACCATGA ACAAGATGAA GAGCTTTAAG CGCCGCCTCT CGCTGTCAGT GCCGCGCACC 60

GAGACCATCG AGGAGTCCTT GGCCGAGTTC ACAGAGCAGT TCAACCAGCT GCACAACCGG 120

CACACTGAGG ACCTGCAGCT CGGGCCTCTC GGCAGAGACC CCCAGCCAGA GTCCAGCACC 180

TTCTCCCCGA CAGACAGTGG GGAGGACCCT GGGCAGCCGT CCCCCGGCCT GCAGTACCGG 240

CGGCAGAGCC AGCGCCGCTT CTCCATGGAG GTGAGGGGCT CTGGGCTCTC CCCTGGGGGG 300

GGGTGGGGGT GCGGCAGGAC TCACCGATGG GTGTGTGCCC GAGGAGGGTG GCTGCCGACA 360

CTGCAGGACA CCAGCAAGAG GCTGTCTCTG CCCATGGACA TCCGCCTGCC CCAGGAATTC 420

CTGCAGAAGC TACAGCTGGA GAGTCCAGAC CTGCCCAAAC CGCTGAGCCG CATGTCCCGC 480

CGAGCATCCC TGTCAGATAT CGGCTTTGGG AAACTGGAAA CATACGTGAA ACTGGACAAA 540

CTGGGGGAGG GTACCTATGC CACAGTCTTC AAAGGGCGCA GCAAGCTGAC GGAGAACCTC 600

GTGGCCCTGA AGGAGATCCG GCTGGAGCAT GAGGAGGGGG CGCCCTGCAC TGCCATCCGA 660

GAGGTGTCTC TCCTGAAGAA TCTAAAGCAC GCCAATATTG TGACCCTGCA TGACCTCATC 720

CATACGGAGC GGTCTCTCAC CCTGGTGTTT GAGTACCTGG ACAGCGACCT GAAGCAGTAT 780

CTGGACCAGT GCGGCAGGCT CGTGAGCATG CACAACGTCA AGATTTTCAT GTTCCAGCTG 840

CTCCGGGGTC TTGCCTACTG CCACCGCCGC AAGATCCTGC ACCGGGACCT GAAGCCGCAG 900

AACCTTCTCA TCAGCGAGAG GGGGGAGCTG AAGCTGGCTG ACTTCGGCCT GGCCCGGGCC 960

AAGTCAGTGC CCACGAAGAC GTACTCCAAC GAGGTGGTGA CCCTGTGGTA CAGGCCCCCT 1020

GATGTGCTGC TGGGGTCCAC GGAGTACTCC ACCCCCATCG ACATGTGGGG CGTGGGCTGC 1080

ATCCACTACG AGATGGCCAC GGGGAGGCCC CTCTTCCCCG GCTCCACGGT CAAGGAGGAG 1140

CTGCACCTCA TCTTCCGACT CCTCGGGACC CCTACGGAAG AGACATGGCC CGGTGTGATG 1200

GCCCTGTCGG AGTTCAGAGC CTACAATTTC CCCCGGTACC TCCCCCAGCC GCTCATCAGC 1260

CACGCTCCCA GGTTGGACAC TGATGGCATC CACCTCCTGA CCAACCTCCT CCTGTATGAA 1320

TCTAAGAGTC GCATGGCAGC AGAGGCAGCC CTGAACCACC CCTACTTCCG GTCTCTGGGA 1380

GAGCGCGTGC ACCAGCTTGA AGACACGGCA TCCATCTTCT CCCTGAAGGA GATCCAGCTC 1440

CAGAAGGACC CAGGTTACCG GGGCCTGGCC TTCCAGCAGC CAGGCCGAGG GAAGAGCCGG 1500

CGACAGAGCA TCTTCTGA 1518

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 175   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  233

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 234   VTLHDLIH-TERSLTLVFEYLDSDLKQYLDQCGR-LVSMHNVKIFMFQLLRGLAYCHRRK  291

         ********.99**********************9.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 292   ILHRDLKPQNLLISERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  351

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +plf+g++ +++l+ if+llgtp+e++wp+v  l+e++ ++fp

Q: 352   PIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVMALSEFRaYNFP  411

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         ++ ++ l ++ ++l++++++ll++ll ++ k+R+ a++al+h+yf

Q: 412   RYLPQPLISHAPRLDTDGIHLLTNLLLYESKSRMAAEAALNHPYF  456

         ********************************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDLIHTER SLTLVFEYLD SDLKQYLDQC GRLVSMHNVK IFMFQLLRGL AYCHRRKILH 120

RDLKPQNLLI SERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MATGRPLFPG STVKEELHLI FRLLGTPTEE TWPGVMALSE FRAYNFPRYL 240

PQPLISHAPR LDTDGIHLLT NLLLYESKSR MAAEAALNHP YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013