EKS-AIM-00348

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00348

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	352.3	1.5E-105	242	481	240

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001694

UniProt Accession

G1L484;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001582	ENSAMEP00000001694	ENSAMET00000001760

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

494

Protein Sequence
(FASTA)

PPLRDPGFGV VTPGSMEPFL RKRLTFLSFF WDKIWPVAGV PGFPDPAASA EPAPSAPEPC 60

GAPAPAQLFR ALYDFTARCS AELSVSRGDR LYALKEEGDY IFARRLSGPP STGLVPITHL 120

AKATPESLSD YPWYFSDISR AQAQQLLLST ANAPGAFLIR PSESSHGDYT LSVRAQATVH 180

HYRIATAADG LYLQKSQLFP SLQELLAYYK ANWKLIRNPL LQPCVPQLPQ QDKWERPRSE 240

FALRRKLGEG YFGEVWEGLW LGSTPVAVKV IKSAYMKLAD LSKEIQTLKS LRHERLIRLH 300

AVCSAGRPVY IVTELMRKGN LQAFLGSPEG RALGLPLLLS FACQVAEGMS YLEERRIVHR 360

DLAARNVLVG DDLACKVADF GLARLLKDDV YSPSSGSKIP VKWTAPEAAT YHIYSPKSDV 420

WSFGVLLYEV FTYGQCPYEG LSNHETLPCP ASCPAEVYTL MLECWRDSPE ERPTFPALQE 480

RLNAAHRRLA PART 494

Nucleotide Sequence
(FASTA)

CCTCCCCTGC GCGACCCTGG GTTCGGCGTG GTGACCCCCG GGAGCATGGA GCCCTTCCTC 60

AGGAAGCGGC TGACCTTCTT GTCCTTCTTC TGGGACAAGA TCTGGCCGGT GGCCGGGGTC 120

CCGGGGTTTC CCGACCCTGC GGCCAGCGCT GAGCCGGCGC CCTCCGCCCC AGAGCCCTGC 180

GGCGCCCCCG CACCCGCGCA GCTCTTCCGG GCGCTCTACG ACTTCACCGC CCGGTGCTCC 240

GCGGAGCTGA GTGTCAGCCG CGGGGACAGG CTCTACGCCC TCAAGGAGGA GGGCGACTAC 300

ATTTTTGCCC GCAGGCTCTC TGGCCCGCCC AGTACTGGGC TGGTACCCAT CACCCACCTG 360

GCCAAGGCCA CCCCGGAGTC TCTCTCAGAC TACCCCTGGT ACTTCAGCGA CATCAGCCGC 420

GCCCAGGCCC AGCAGCTGCT CTTGTCCACG GCCAACGCGC CGGGCGCCTT CCTCATTCGG 480

CCCAGCGAGA GCAGCCACGG GGACTACACG CTATCAGTCC GGGCCCAGGC CACCGTTCAC 540

CACTACCGCA TCGCCACGGC GGCCGACGGT CTCTACCTGC AGAAGAGCCA GCTCTTCCCC 600

AGCCTGCAGG AGCTGCTCGC CTACTACAAG GCCAACTGGA AGCTGATCCG GAACCCGCTG 660

CTGCAGCCCT GTGTGCCCCA GCTCCCCCAG CAGGACAAGT GGGAGCGGCC TCGCTCCGAG 720

TTTGCCCTTC GGAGGAAGCT GGGTGAAGGC TACTTTGGGG AGGTGTGGGA AGGCCTGTGG 780

CTGGGCTCCA CGCCAGTGGC GGTCAAGGTC ATTAAGTCAG CCTACATGAA GCTCGCAGAC 840

CTCAGCAAGG AGATCCAGAC GCTGAAGAGC CTGCGACACG AGCGTCTCAT TCGGCTGCAT 900

GCCGTGTGCT CCGCGGGCCG GCCCGTGTAC ATCGTCACTG AGCTCATGCG CAAGGGCAAT 960

CTGCAGGCCT TCCTGGGGAG CCCTGAGGGG CGGGCCCTGG GCCTGCCTCT CCTGCTGAGC 1020

TTCGCCTGCC AGGTGGCCGA GGGCATGAGC TACCTGGAGG AGCGGCGCAT CGTACACCGC 1080

GACCTGGCGG CCAGGAACGT GCTCGTGGGC GACGACCTGG CATGCAAGGT GGCTGACTTT 1140

GGCCTGGCCC GGCTGCTCAA GGATGACGTC TACTCCCCAA GCAGTGGCTC CAAGATCCCT 1200

GTCAAGTGGA CGGCGCCCGA GGCGGCCACC TACCACATCT ACTCCCCGAA GTCGGACGTC 1260

TGGTCCTTCG GTGTTCTCCT CTATGAGGTC TTCACCTATG GCCAGTGTCC CTATGAAGGG 1320

CTGAGCAACC ATGAGACCCT GCCGTGCCCG GCCTCCTGCC CCGCGGAGGT CTACACGCTC 1380

ATGCTGGAGT GCTGGAGGGA CAGCCCCGAG GAGCGGCCGA CCTTCCCTGC GCTGCAGGAG 1440

AGGCTGAATG CGGCCCACAG GCGCCTCGCC CCCGCCCGCA CATGA 1485

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w gs++vavk++k++ ++ +++ +e+q+lk+lrhe+l++l+a

Q: 242   ALRRKLGEGYFGEVWEGLWLGSTPVAVKVIKSAYMKLADLSKEIQTLKSLRHERLIRLHA  301

         688*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s++ P+yivtelm+kG+l++fl + eg++l lp l+ +a+qvaeGm+ylee++++hrd

Q: 302   VCSAGRPVYIVTELMRKGNLQAFLGSPEGRALGLPLLLSFACQVAEGMSYLEERRIVHRD  361

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlvg++l++kvadfGlarl++dd y++++g+k+P+kWtaPea++++ ++ ksdvW

Q: 362   LAARNVLVGDDLACKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAATYHIYSPKSDVW  421

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfG+ll+e++t+G++Py+G++n+e+         lp+p++cp+e+y+l+lecw+ +peer

Q: 422   SFGVLLYEVFTYGQCPYEGLSNHET---------LPCPASCPAEVYTLMLECWRDSPEER  472

         ************************8.........6*************************

S: 242   Ptfetlqev  250

         Ptf +lqe

Q: 473   PTFPALQER  481

         ******986

Domain Sequence
(FASTA)

ALRRKLGEGY FGEVWEGLWL GSTPVAVKVI KSAYMKLADL SKEIQTLKSL RHERLIRLHA 60

VCSAGRPVYI VTELMRKGNL QAFLGSPEGR ALGLPLLLSF ACQVAEGMSY LEERRIVHRD 120

LAARNVLVGD DLACKVADFG LARLLKDDVY SPSSGSKIPV KWTAPEAATY HIYSPKSDVW 180

SFGVLLYEVF TYGQCPYEGL SNHETLPCPA SCPAEVYTLM LECWRDSPEE RPTFPALQER 240

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013