EKS-AIM-00149
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00149
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK335.42.8E-1001260260
StatusUnreviewed
Ensembl ProteinENSAMEP00000001865
UniProt AccessionG1L4Q5;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000001721ENSAMEP00000001865ENSAMET00000001941
OrganismAiluropoda melanoleuca
Functional Description
Protein Length811
Protein Sequence
(FASTA)
AYGKVFLVRK ISGHDAGKLY AMKVLKKATI VQKAKTTEHT RTERQVLEHI RQSPFLVTLH 60
YAFQTETKLH LILDYINGGE LFTHLSQRER FTEHEVRIYV GEIVLALEHL HKLGIIYRDI 120
KLENILLDSN GHVVLTDFGL SKEFVAEEAE RAYSFCGTIE YMAPDIVRGG DSGHDKAVDW 180
WSLGVLMYEL LTGASPFTVD GEKNSQAEIS RRILKSEPPY PQEMSALAKD LIQRLLMKDP 240
KKRLGCGPRD ADEIKEHLFF QKINWDDLAA KKVPTPFKPV IRDELDVSNF AEEFTEMDPT 300
YSPAALPQSS ERLFQGYSFV APSILFKRNA AVIDPLQFHM GVERPGVTNV ARSAMMKDSP 360
FYQHYDLDLK DKPLGEGSFS ICRKCIHKKS NQAFAVKIIS KRMEANTQKE ITALKLCEGH 420
PNIVKLHEVF HDQMPYCTQT AGQLTLPPPL SVLLSNRSPA QKHGTLHTGG VPLCQVHASS 480
SAPPQPPPQN DIVIYVLCGS HSQLHTFLVM ELLNGGELFE RIKKKKHFSE TEASYIMRKL 540
VSAVSHMHDV GVVHRDLKPE NLLFTDENDN LEIKVIDFGF ARLKPPDNQP LKTPCFTLHY 600
AAPELLNHNG YDESCDLWSL GVILYTMLSG QVPFQSHDKS LTCTSAVEIM KKIKKGDFSF 660
EGEAWKNVSQ EAKALIQGLL TVDPNKRLKM SGLRYNEWLQ DGSQLSSNPL MTPDILGSSG 720
AAVQTCVKAT FHAFNKYKRE GFCLQNVDKA PLAKRRKMKK TSTSTETRSS SSESSHSSSS 780
HSHGKTTPTK TLQPSNPADP SNPDTLFQFS D 811
Nucleotide Sequence
(FASTA)
GCTTATGGAA AAGTATTTCT GGTTCGTAAA ATCAGTGGTC ACGACGCTGG CAAGCTGTAT 60
GCTATGAAAG TCTTGAAAAA GGCCACAATA GTGCAAAAGG CCAAAACCAC AGAGCACACA 120
AGGACTGAGC GGCAAGTCCT GGAGCACATC AGGCAGTCGC CATTCTTGGT GACCTTGCAC 180
TACGCTTTCC AGACAGAAAC CAAACTTCAT CTCATTTTAG ATTATATAAA TGGTGGAGAA 240
CTTTTTACTC ATCTTTCTCA AAGAGAGCGT TTCACAGAGC ATGAGGTGCG GATCTATGTT 300
GGAGAGATCG TGCTTGCCCT CGAACATCTC CACAAGTTGG GAATTATATA CCGTGACATT 360
AAGCTTGAGA ACATTCTACT TGATTCTAAT GGCCACGTGG TGCTGACAGA TTTTGGTCTG 420
AGTAAGGAGT TTGTGGCTGA AGAAGCTGAA AGAGCATATT CCTTTTGTGG GACTATTGAA 480
TACATGGCAC CGGATATTGT CAGAGGGGGA GATTCAGGAC ACGACAAGGC AGTTGACTGG 540
TGGAGTTTAG GTGTTCTAAT GTATGAATTA CTTACTGGAG CATCTCCTTT CACTGTGGAT 600
GGGGAGAAGA ATTCCCAAGC TGAGATATCT AGGAGAATAT TAAAAAGTGA GCCTCCATAT 660
CCTCAAGAAA TGAGTGCTTT AGCTAAAGAC CTAATTCAGC GTCTTTTGAT GAAAGATCCC 720
AAGAAAAGAT TGGGATGTGG TCCACGTGAT GCGGATGAGA TCAAAGAACA TCTCTTTTTC 780
CAGAAAATCA ATTGGGATGA TTTAGCTGCC AAAAAAGTGC CCACGCCATT TAAGCCAGTC 840
ATCCGAGACG AACTAGATGT GAGTAACTTC GCAGAAGAGT TCACGGAGAT GGACCCCACC 900
TACTCCCCGG CGGCACTGCC CCAGAGCTCC GAGAGGCTGT TCCAGGGCTA TTCCTTTGTC 960
GCTCCTTCTA TTCTGTTCAA GCGTAATGCA GCTGTCATAG ATCCTCTTCA GTTTCACATG 1020
GGAGTTGAAC GTCCCGGAGT GACAAATGTT GCCAGGAGTG CAATGATGAA GGACTCCCCG 1080
TTCTATCAAC ACTATGACCT GGATCTGAAG GACAAGCCCC TGGGAGAGGG AAGTTTTTCA 1140
ATTTGTCGAA AGTGCATACA CAAAAAAAGT AACCAAGCCT TCGCAGTCAA AATAATCAGC 1200
AAGAGGATGG AAGCCAATAC TCAGAAAGAA ATAACAGCTC TGAAGCTCTG TGAAGGGCAC 1260
CCCAACATCG TGAAATTGCA CGAAGTTTTT CACGATCAGA TGCCATATTG CACCCAGACC 1320
GCAGGCCAGC TCACTCTGCC GCCTCCTCTC TCAGTCCTGC TTTCCAACAG GAGCCCAGCA 1380
CAGAAGCATG GAACTCTGCA CACGGGAGGA GTGCCGCTGT GTCAGGTCCA TGCCTCCTCC 1440
TCAGCCCCTC CACAGCCACC TCCCCAAAAT GACATTGTCA TCTACGTGCT CTGTGGTTCA 1500
CATAGTCAGC TGCACACGTT TCTGGTGATG GAACTTCTGA ACGGGGGAGA GCTGTTTGAA 1560
CGCATTAAGA AAAAGAAGCA CTTCAGTGAG ACTGAAGCCA GTTACATCAT GCGGAAGCTC 1620
GTTTCGGCCG TGAGCCACAT GCATGATGTG GGCGTGGTGC ACAGGGACCT GAAGCCCGAG 1680
AATTTATTGT TCACTGATGA AAATGACAAT TTGGAAATTA AAGTAATCGA TTTTGGGTTT 1740
GCACGCTTAA AGCCGCCTGA TAACCAGCCT CTCAAGACGC CCTGCTTCAC CCTGCACTAC 1800
GCCGCCCCCG AGCTCTTGAA TCACAACGGC TACGACGAGT CCTGCGACCT CTGGAGCCTG 1860
GGCGTCATTT TGTATACAAT GTTGTCAGGG CAAGTTCCAT TCCAGTCTCA TGACAAAAGT 1920
TTGACATGTA CCAGTGCGGT GGAAATCATG AAGAAAATTA AAAAGGGAGA TTTCTCCTTT 1980
GAAGGAGAAG CCTGGAAGAA TGTATCCCAA GAAGCTAAAG CCTTGATCCA AGGACTCCTC 2040
ACAGTCGACC CAAATAAAAG ACTTAAAATG TCAGGCTTGA GATACAACGA ATGGCTTCAA 2100
GATGGCAGTC AGCTGTCCTC CAATCCTCTG ATGACTCCGG ACATTCTAGG ATCTTCGGGA 2160
GCTGCCGTGC AAACCTGTGT GAAAGCAACC TTCCACGCCT TTAACAAATA CAAGAGAGAG 2220
GGGTTTTGCC TTCAGAATGT CGACAAGGCC CCTTTGGCAA AGAGAAGGAA AATGAAGAAG 2280
ACCAGCACCA GCACAGAGAC ACGCAGCAGC TCTAGCGAAA GTTCTCACTC GTCCTCCTCT 2340
CACTCCCACG GGAAGACCAC GCCCACTAAG ACCCTGCAGC CCAGCAACCC CGCGGACCCC 2400
AGCAACCCAG ACACGCTCTT CCAGTTCTCG GACTGA 2436
Domain Profile
S: 11    aygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeeveh.pfivklh  67
         aygkvflvrk++++d+gklya+Kvlkka++v+  k++e+t++er++Le++++ pf+v+lh
Q: 1     AYGKVFLVRKISGHDAGKLYAMKVLKKATIVQkaKTTEHTRTERQVLEHIRQsPFLVTLH  60
         7******************************988999***********************
S: 68    eafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylHskgvvyrDL  127
         +afq+e+kl+l+l++++GgeL+++l+++++f+e+e++ ++ e+vlale+lH+ g++yrD+
Q: 61    YAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVRIYVGEIVLALEHLHKLGIIYRDI  120
         ************************************************************
S: 128   kpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevl..krkgydeavDl  185
         k+eNilld++ghv+ltDfgl+ke +ae+ e+aysfcgT+ey+aP+++   ++g+d+avD+
Q: 121   KLENILLDSNGHVVLTDFGLSKEFVAEEAERAYSFCGTIEYMAPDIVrgGDSGHDKAVDW  180
         ***********************************************76679********
S: 186   wslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvkklLkkdp  245
         wslGvl+ye+LtG++Pft + +k+++a+i +  ++ + p  +e+s+ akdl+++lL kdp
Q: 181   WSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDP  240
         ***********************88887777776666777777*****************
S: 246   akRlga...taeeikehkfl  262
         +kRlg+   +a+eikeh f+
Q: 241   KKRLGCgprDADEIKEHLFF  260
         *****************997
Domain Sequence
(FASTA)
AYGKVFLVRK ISGHDAGKLY AMKVLKKATI VQKAKTTEHT RTERQVLEHI RQSPFLVTLH 60
YAFQTETKLH LILDYINGGE LFTHLSQRER FTEHEVRIYV GEIVLALEHL HKLGIIYRDI 120
KLENILLDSN GHVVLTDFGL SKEFVAEEAE RAYSFCGTIE YMAPDIVRGG DSGHDKAVDW 180
WSLGVLMYEL LTGASPFTVD GEKNSQAEIS RRILKSEPPY PQEMSALAKD LIQRLLMKDP 240
KKRLGCGPRD ADEIKEHLFF 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Danio rerio"; ?>Mus musculus"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00151
EKS-DAR-00452
EKS-MUM-00161
EKS-PES-00139
EKS-RAN-00154
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 3.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013