EKS-AIM-00342
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00342
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src442.73.6E-133247497251
StatusUnreviewed
Ensembl ProteinENSAMEP00000001862
UniProt AccessionG1L4Q2;
Protein Name
Protein Synonyms/Alias
Gene NameLYN
Gene Synonyms/Alias LYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000001737ENSAMEP00000001862ENSAMET00000001938
OrganismAiluropoda melanoleuca
Functional Description
Protein Length512
Protein Sequence
(FASTA)
MGCIKSKRKD NLNDDGIDLK TQPVRNTDRT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 60
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEELGEWW KAKSLSTKRE GFIPSNYVAK 120
VNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSYSLSVR DYDPVHGDVI 180
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW 240
EIPRDSIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300
KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360
KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420
TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPD ELYDIMKMCW 480
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512
Nucleotide Sequence
(FASTA)
ATGGGATGTA TAAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGGAT AGATTTGAAG 60
ACTCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120
CAGCAAAGGC CAGTTCCAGA ATCTCAGCTT TTACCAGGAC AGAGGTTCCA AACTAAAGAT 180
CCGGAGGAGC AAGGAGACAT CGTGGTAGCC TTGTACCCCT ATGATGGCAT CCACCCGGAC 240
GACTTGTCTT TCAAAAAAGG AGAGAAGATG AAAGTCCTGG AGGAGCTTGG AGAATGGTGG 300
AAAGCTAAAT CCCTTTCAAC AAAGAGAGAA GGGTTCATCC CCAGCAACTA CGTTGCCAAA 360
GTCAACACCT TAGAAACGGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA AGACGCAGAA 420
AGGCAGCTGC TGGCTCCAGG GAACAGTGCT GGAGCTTTTC TTATTAGAGA AAGCGAAACC 480
TTAAAAGGAA GCTACTCTCT TTCTGTCAGA GATTATGACC CTGTGCATGG TGATGTTATT 540
AAGCACTACA AAATTAGAAG TCTGGACAAT GGAGGTTATT ACATCTCTCC ACGAATCACT 600
TTTCCTTGTA TCAGTGACAT GATTAAACAT TACCAAAAGC AGTCCGATGG CTTGTGCAGA 660
AGATTGGAGA AGGCGTGTAT TAGCCCCAAA CCACAAAAGC CATGGGACAA AGATGCCTGG 720
GAGATCCCAC GGGATTCCAT CAAGTTGGTG AAAAGGCTTG GTGCCGGGCA GTTCGGGGAA 780
GTCTGGATGG GTTACTATAA CAATAGTACC AAAGTGGCTG TGAAAACCCT GAAACCAGGC 840
ACTATGTCTG TGCAAGCTTT CCTGGAGGAA GCCAACCTCA TGAAGACCCT TCAGCATGAC 900
AAGCTGGTGA GGCTGTATGC CGTGGTCACC AGAGAGGAGC CTATCTACAT CATCACCGAG 960
TATATGGCCA AGGGCAGTTT GCTGGATTTC CTGAAGAGCG ATGAAGGGGG CAAAGTGCTG 1020
CTTCCAAAGC TAATTGACTT TTCTGCCCAG ATTGCAGAGG GAATGGCGTA CATTGAGAGG 1080
AAGAACTACA TTCACCGAGA CCTACGAGCA GCAAACGTTC TGGTCTCTGA GTCCCTCATG 1140
TGCAAAATTG CAGATTTTGG CCTTGCTCGA GTAATTGAAG ATAATGAGTA CACAGCAAGG 1200
GAAGGTGCCA AATTCCCCAT TAAGTGGACA GCTCCGGAAG CAATCAACTT CGGATGTTTC 1260
ACGATTAAGT CTGATGTGTG GTCCTTTGGA ATTCTCTTGT ATGAGATCGT CACCTATGGG 1320
AAAATTCCCT ACCCAGGGAG AACTAATGCC GACGTGATGA CCGCCCTGTC CCAGGGCTAC 1380
AGGATGCCCC GCATGGAGAA CTGCCCAGAT GAGCTCTATG ACATCATGAA AATGTGCTGG 1440
AAGGAAAAGG CAGAAGAGAG GCCAACGTTT GATTACTTGC AGAGCGTCCT GGATGATTTC 1500
TACACTGCCA CAGAAGGGCA GTATCAGCAG CAGCCTTGA 1539
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly
Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr
Q: 307   AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr+e+cp+ely+++++cwk+++ee
Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMENCPDELYDIMKMCWKEKAEE  486
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++lq+vl
Q: 487   RPTFDYLQSVL  497
         ********986
Domain Sequence
(FASTA)
IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60
AVVTREEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120
DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180
WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRME NCPDELYDIM KMCWKEKAEE 240
RPTFDYLQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00358
EKS-BOT-00368
EKS-CAJ-00372
EKS-CAF-00369
EKS-CAP-00401
EKS-DAR-00748
EKS-EQC-00359
EKS-GAM-00222
EKS-GAG-00312
EKS-GAA-00452
EKS-GOG-00359
EKS-HOS-00374
EKS-ICT-00348
EKS-LAC-00384
EKS-LOA-00377
EKS-MAM-00368
EKS-MOD-00359
EKS-MUM-00400
EKS-MUP-00362
EKS-MYL-00366
EKS-NOL-00336
EKS-ORN-00477
EKS-ORA-00322
EKS-ORC-00346
EKS-ORL-00439
EKS-OTG-00372
EKS-PAT-00348
EKS-PES-00327
EKS-POA-00358
EKS-RAN-00382
EKS-SAH-00338
EKS-SUS-00327
EKS-TAG-00441
EKS-TAS-00040
EKS-TEN-00466
EKS-XET-00488
EKS-XIM-00465
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001782; P:B cell homeostasis
GO:0050853; P:B cell receptor signaling pathway
GO:0071300; P:cellular response to retinoic acid
GO:0097028; P:dendritic cell differentiation
GO:0030218; P:erythrocyte differentiation
GO:0002774; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0030889; P:negative regulation of B cell proliferation
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407; P:negative regulation of MAP kinase activity
GO:0070667; P:negative regulation of mast cell proliferation
GO:0002762; P:negative regulation of myeloid leukocyte differentiation
GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175; P:neuron projection development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0002576; P:platelet degranulation
GO:0030335; P:positive regulation of cell migration
GO:2000670; P:positive regulation of dendritic cell apoptotic process
GO:0070668; P:positive regulation of mast cell proliferation
GO:0010976; P:positive regulation of neuron projection development
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902; P:regulation of B cell apoptotic process
GO:0050855; P:regulation of B cell receptor signaling pathway
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0050707; P:regulation of cytokine secretion
GO:0045646; P:regulation of erythrocyte differentiation
GO:0050727; P:regulation of inflammatory response
GO:0043304; P:regulation of mast cell degranulation
GO:0090025; P:regulation of monocyte chemotaxis
GO:0090330; P:regulation of platelet aggregation
GO:0006974; P:response to DNA damage stimulus
GO:0009725; P:response to hormone stimulus
GO:0002513; P:tolerance induction to self antigen
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
aml:100479606;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013