EKS-AIM-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	3.8E-137	208	495	288

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001897

UniProt Accession

G1L4T7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001774	ENSAMEP00000001897	ENSAMET00000001974

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

RIKHTQQSSL VPDIIAHTAY WGGERTPEFP AALQCACTSC LQANYTCETD GACMVSIFNL 60

DGMEHHVRTC IPKVELVPAG KPFYCLSSED LRNTHCCYTD FCNKIDLRVP SGHLKESEHP 120

SVWGPVELVG IIAGPVFLLF LIIIVVFLVI NYHQRVYHNR QRLDMEDPSC EMCLSKDKTL 180

QDLVYDLSTS GSGSGLPLFV QRTVARTIVL QEIIGKGRFG EVWRGRWRGG DVAVKIFSSR 240

EERSWFREAE IYQTVMLRHE NILGFIAADN KDNGTWTQLW LVSDYHEHGS LFDYLNRYTV 300

TIEGMIKLAL SAASGLAHLH MEIVGTQGKP GIAHRDLKSK NILVKKNGMC AIADLGLAVR 360

HDAVTDTIDI APNQRVGTKR YMAPEVLDET INMKHFDSFK CADIYALGLV YWEIARRCNS 420

GGVHEEYQLP YYDLVPSDPS IEEMRKVVCD QKLRPNIPNW WQSYEALRVM GKMMRECWYA 480

NGAARLTALR IKKTLSQLSV QEDVKI 506

Nucleotide Sequence
(FASTA)

CGTATAAAAC ACACCCAGCA GAGCTCATTA GTCCCAGACA TAATTGCACA CACTGCCTAT 60

TGGGGGGGGG AACGTACTCC CGAATTTCCT GCAGCTCTGC AGTGTGCGTG TACCAGCTGC 120

CTCCAGGCCA ACTACACGTG TGAGACAGAT GGGGCCTGCA TGGTTTCCAT TTTCAACCTG 180

GATGGGATGG AGCACCACGT GCGCACCTGC ATCCCCAAAG TGGAGCTGGT CCCTGCTGGG 240

AAGCCCTTCT ATTGCCTGAG CTCCGAGGAT CTCCGCAACA CCCACTGCTG CTATACTGAC 300

TTCTGCAATA AGATCGACCT GAGGGTGCCC AGTGGTCACC TCAAGGAGTC TGAGCACCCT 360

TCCGTGTGGG GCCCTGTGGA GCTCGTAGGC ATTATCGCTG GCCCAGTGTT CCTCCTGTTT 420

CTCATCATCA TCGTCGTTTT CCTTGTCATT AACTACCATC AGCGTGTCTA TCACAACCGC 480

CAGAGACTGG ACATGGAAGA TCCCTCGTGC GAGATGTGCC TGTCCAAAGA CAAGACGCTG 540

CAGGACCTTG TCTACGATCT CTCGACATCA GGGTCTGGCT CAGGGTTGCC CCTTTTTGTC 600

CAGCGCACGG TGGCCCGAAC CATCGTTTTG CAGGAGATTA TTGGCAAGGG CCGGTTTGGG 660

GAAGTGTGGC GTGGCCGTTG GAGGGGTGGT GACGTGGCTG TGAAGATTTT CTCTTCTCGT 720

GAAGAACGGT CTTGGTTTCG GGAAGCAGAG ATATACCAGA CAGTCATGCT GCGCCACGAA 780

AACATCCTTG GATTTATTGC TGCTGACAAT AAAGATAATG GCACCTGGAC ACAGCTGTGG 840

CTCGTCTCAG ACTACCATGA GCATGGCTCC CTGTTTGATT ATCTGAACCG ATACACAGTG 900

ACGATCGAGG GGATGATTAA GCTGGCCTTG TCTGCGGCTA GCGGGCTGGC ACACCTGCAC 960

ATGGAGATTG TGGGTACCCA AGGGAAGCCT GGAATTGCTC ATCGAGACTT AAAGTCAAAG 1020

AACATCCTGG TGAAGAAGAA TGGCATGTGC GCCATTGCAG ACCTGGGCCT GGCTGTCCGC 1080

CATGACGCGG TCACGGACAC CATCGACATC GCCCCAAATC AGAGGGTGGG GACCAAACGA 1140

TACATGGCCC CCGAAGTGCT CGACGAAACC ATTAACATGA AGCATTTCGA CTCCTTCAAG 1200

TGTGCGGACA TCTATGCCCT CGGGCTTGTG TACTGGGAGA TTGCTCGAAG ATGTAACTCC 1260

GGAGGAGTCC ATGAAGAATA TCAGCTGCCA TATTATGACC TAGTGCCCTC TGACCCTTCC 1320

ATTGAAGAGA TGCGAAAGGT CGTATGTGAC CAGAAGCTAC GTCCCAACAT CCCCAACTGG 1380

TGGCAGAGTT ATGAGGCGCT ACGGGTGATG GGGAAGATGA TGCGAGAGTG TTGGTACGCC 1440

AACGGCGCGG CCCGCCTGAC CGCTCTGCGC ATTAAGAAGA CCCTCTCACA GCTCAGCGTG 1500

CAGGAAGATG TGAAGATCTA A 1521

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 208   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  267

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 268   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  327

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 328   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  385

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 386   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  444

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 445   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  495

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001942	; P:hair follicle development
GO:0001701	; P:in utero embryonic development
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013