EKS-AIM-00067

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00067

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	338.9	2.3E-101	26	335	310

Status

Unreviewed

Ensembl Protein

ENSAMEP00000001917

UniProt Accession

D2HP84;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8; PANDA_013566;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000001794	ENSAMEP00000001926	ENSAMET00000002003
ENSAMEG00000001794	ENSAMEP00000001917	ENSAMET00000001994

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300

KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLT 360

EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP LKKVRVVPPT TTSGGLIMTS 420

DYQRSNPHAA YPNPGPSTSQ PQSSMGYSTT SQQPPQYSHQ THRY 464

Nucleotide Sequence
(FASTA)

ATGGACTATG ACTTTAAAGT GAAGCTGAGC AGCGAGCGGG AGCGGGTCGA GGACCTGTTT 60

GAATACGAGG GCTGCAAAGT TGGCCGAGGC ACTTATGGTC ACGTCTACAA AGCCAAGAGG 120

AAAGATGGGA AAGATGATAA AGACTATGCT TTAAAACAAA TAGAAGGAAC TGGGATCTCT 180

ATGTCGGCAT GTAGAGAAAT AGCATTACTT CGAGAGCTTA AGCATCCAAA TGTCATCTCT 240

CTTCAAAAGG TATTTCTGTC TCATGCTGAT AGGAAAGTAT GGCTTCTGTT TGACTACGCT 300

GAACATGACC TCTGGCATAT AATCAAGTTT CACAGAGCTT CTAAAGCAAA CAAGAAGCCA 360

GTTCAGTTAC CTCGGGGAAT GGTGAAGTCA CTATTATATC AGATCCTAGA TGGGATTCAC 420

TACCTGCATG CTAACTGGGT GTTGCACAGG GATTTGAAAC CTGCTAATAT TTTAGTTATG 480

GGTGAAGGTC CTGAGCGAGG AAGAGTAAAA ATTGCTGATA TGGGCTTTGC CCGATTATTT 540

AATTCACCTT TGAAGCCTTT AGCAGATTTG GATCCAGTAG TCGTAACATT CTGGTACCGA 600

GCCCCAGAAT TACTTCTTGG AGCGAGACAT TATACCAAAG CTATTGATAT TTGGGCTATA 660

GGGTGTATAT TTGCAGAACT ACTAACGTCA GAACCAATAT TTCACTGTCG ACAAGAGGAC 720

ATCAAAACTA GTAATCCTTA TCACCATGAC CAGCTGGACA GAATATTCAA TGTAATGGGA 780

TTTCCTGCAG ATAAAGATTG GGAAGATATA AAAAAGATGC CTGAACATTC AACATTAATG 840

AAAGATTTCA GAAGAAATAC GTATACCAAC TGCAGCCTTA TCAAGTATAT GGAAAAACAT 900

AAAGTTAAAC CAGATAGTAA AGCATTCCAC TTGCTTCAGA AGTTGCTTAC CATGGACCCA 960

ATAAAGCGAA TTACCTCAGA ACAGGCTATG CAGGATCCCT ATTTCTTAGA AGATCCACTT 1020

CCTACATCAG ATGTTTTTGC CGGTTGTCAA ATCCCTTACC CAAAACGAGA ATTTTTAACA 1080

GAAGAAGAAC CTGATGACAA AGGAGACAAA AAGAACCAGC AGCAGCAGCA GGGCAATAAC 1140

CATACTAATG GAACTGGTCA CCCAGGGAAT CAAGACAGCA GTCATACACA GGGACCCCCG 1200

TTGAAAAAAG TGAGAGTTGT TCCTCCTACC ACTACCTCAG GTGGACTAAT CATGACCTCA 1260

GACTATCAGC GTTCCAATCC ACATGCTGCC TATCCCAACC CTGGACCAAG CACATCACAG 1320

CCACAGAGCA GCATGGGATA CTCAACTACC TCCCAGCAGC CTCCACAGTA CTCACATCAG 1380

ACACACCGGT AC 1392

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkpvQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999999********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++dp

Q: 262   PADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPI  321

         ***************96644777777764455666644333354679*************

S: 271   kRisakealqhkyf  284

         kRi++++a+q++yf

Q: 322   KRITSEQAMQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPVQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PYHHDQLDRI FNVMGFPADK 240

DWEDIKKMPE HSTLMKDFRR NTYTNCSLIK YMEKHKVKPD SKAFHLLQKL LTMDPIKRIT 300

SEQAMQDPYF 310

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016592	; C:mediator complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

aml:100467099

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013