EKS-AIM-00263
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00263
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR433.14.7E-130204490287
StatusUnreviewed
Ensembl ProteinENSAMEP00000001935
UniProt AccessionG1L4X5;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000001811ENSAMEP00000001935ENSAMET00000002012
OrganismAiluropoda melanoleuca
Functional Description
Protein Length504
Protein Sequence
(FASTA)
MTCDPPRRGL LMLLMALGLT RGDPVKPSWG PLVTCTCESP HCKGPTCQGA WCTVVLVREE 60
GHHPQEHRGC GSLHEELCRG RPTEFVNHYC CYSPLCNHNV SLVLEATQTP PEQPKVDGQL 120
PLILGPVLAL LVLGALGALG LWHVRRRQEK PRGLHSELGE SSLILKASEQ GDSMLGDLLD 180
SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG LWHGESVAVK IFSSRDEQSW 240
FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQGS 360
DYLDIGNNPR VGTKRYMAPE VLEEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIVNGIVE 420
DYRPPFYDVV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR 480
LTALRVKKTL QKLSTGLQKP KVTH 504
Nucleotide Sequence
(FASTA)
ATGACCTGCG ACCCCCCCAG GAGAGGCCTT CTGATGCTTC TGATGGCCTT GGGCCTGACC 60
CGGGGCGACC CTGTGAAGCC CTCTTGGGGT CCGCTGGTGA CCTGCACCTG TGAGAGCCCG 120
CACTGCAAGG GGCCTACGTG CCAGGGGGCC TGGTGCACGG TCGTGCTGGT GCGGGAGGAG 180
GGCCACCACC CCCAGGAACA CCGGGGCTGT GGGAGCCTGC ACGAGGAGCT GTGCCGGGGG 240
CGCCCCACCG AGTTCGTCAA CCACTACTGC TGCTACAGCC CCCTCTGCAA CCACAACGTG 300
TCCCTGGTGC TGGAGGCCAC CCAAACTCCT CCGGAGCAGC CGAAGGTAGA TGGCCAGCTG 360
CCTCTGATCC TGGGCCCCGT GCTGGCCTTG TTGGTCCTGG GGGCCCTGGG CGCCCTGGGC 420
CTGTGGCATG TCCGGCGGAG GCAGGAGAAG CCGCGGGGCC TGCACAGCGA GCTGGGGGAG 480
TCCAGCCTCA TCCTGAAGGC ATCCGAGCAG GGGGACAGCA TGCTGGGGGA TCTCCTGGAC 540
AGTGACTGCA CCACGGGCAG TGGCTCAGGA CTCCCCTTCC TGGTGCAAAG GACAGTGGCG 600
CGGCAGGTGG CCCTCGTGGA GTGTGTAGGC AAGGGCCGCT ATGGCGAGGT GTGGCGTGGC 660
TTGTGGCATG GTGAGAGCGT GGCTGTCAAA ATCTTCTCTT CGAGGGATGA ACAGTCCTGG 720
TTCCGGGAGA CTGAGATCTA CAATACAGTG CTGCTCAGAC ACGACAACAT CCTAGGCTTT 780
ATCGCCTCCG ACATGACGTC CCGCAACTCA AGCACGCAGC TGTGGCTCAT CACGCACTAC 840
CACGAGCACG GCTCGCTCTA CGACTTTCTG CAGAGGCAGA CGCTGGAGCC CCAGCTGGCC 900
CTGAGGCTAG CTGTGTCGGC CGCCTGCGGC CTGGCTCACC TGCACGTGGA GATCTTCGGC 960
ACGCAGGGCA AGCCGGCCAT CGCCCACCGA GACCTCAAAA GCCGCAACGT CCTGGTCAAG 1020
AGCAACCTGC AGTGCTGCAT TGCCGACCTG GGCCTAGCTG TGATGCACTC CCAGGGTAGC 1080
GATTACCTGG ACATCGGCAA CAACCCGCGA GTGGGCACCA AGCGGTACAT GGCCCCCGAG 1140
GTGCTGGAAG AACAGATCCG CACCGACTGC TTCGAGTCCT ACAAGTGGAC AGACATCTGG 1200
GCCTTTGGCC TGGTGCTGTG GGAGATTGCC CGTCGGACCA TTGTCAACGG CATCGTGGAG 1260
GACTACAGGC CCCCCTTCTA TGATGTGGTG CCCAATGATC CCAGCTTTGA GGACATGAAG 1320
AAGGTGGTGT GTGTAGATCA GCAGACCCCC ACCATCCCCA ACCGGCTGGC TGCAGACCCG 1380
GTCCTCTCAG GCCTGGCTCA GATGATGCGG GAGTGCTGGT ACCCCAACCC CTCTGCCCGC 1440
CTCACTGCAC TGCGCGTCAA GAAGACACTG CAGAAACTCA GCACCGGTCT CCAGAAGCCC 1500
AAAGTGACTC ACTAG 1515
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 204   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  263
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+g
Q: 264   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQG  323
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv
Q: 324   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  381
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         lee++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+mk
Q: 382   LEEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  440
         ********************************99.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalrvkk+l
Q: 441   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRVKKTL  490
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALRL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLE 180
EQIRTDCFES YKWTDIWAFG LVLWEIARRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240
CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRVKKTL 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-FEC-00267
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-LOA-00291
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
aml:100482358;
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013