EKS-AIM-00006
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00006
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph513.67.3E-155580839260
StatusUnreviewed
Ensembl ProteinENSAMEP00000002020
UniProt AccessionG1L560;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000001862ENSAMEP00000002020ENSAMET00000002101
OrganismAiluropoda melanoleuca
Functional Description
Protein Length945
Protein Sequence
(FASTA)
WEEVSGYDEN LNTIRTYQVC NVFEPNQNNW LLTTFINRRG AHRIYTEMRF TVRDCSSLPN 60
VPGSCKETFN LYYYETDSVI ATKKSAFWSE APYLKVDTIA ADESFSQVDF GGRLMKVNTE 120
VRSFGPLTRN GFYLAFQDYG ACMSLLSVRV FFKKCPSIVQ NFAVFPETMT GAESTSLVIA 180
RGTCIPNAEE VDVPIKLYCN GDGEWMVPIG RCTCKPGYEA ENSVACKACP AGMFKASQEA 240
EGCSHCPSNS RSPSEASPIC TCRTGYYRAD FDPPEVACTS VPSGPRNVIS IVNETSIILE 300
WHPPRETGGR DDVTYNIICR KCRADRRSCS RCDDNVEFVP RQLGLTECRV SISSLWAHTP 360
YTFDIQAVNG VSSKSPFPPQ HVSVNITTNQ AAPSTVPIMH QVSATMKSIT LSWPQPEQPN 420
GIILDYEIRY YEKEHNEFNS SMARSQTNTA RIDGLRPGMV YVVQVRARTV AGYGKFSGKM 480
CFQTLTDESS QLRETETLPS VFKLGVYGLK FLLTNIQCKV LCQNNSFSRA RGQSTEMTEQ 540
ESTLGHTSSP GMKIYIDPFT YEDPNEAVRE FAKEIDVSFV KIEEVIGAGE FGEVYKGRLK 600
LPGKREIYVA IKTLKAGYSE KQRRDFLSEA SIMGQFDHPN IIRLEGVVTK SRPVMIITEF 660
MENGALDSFL RQNDGQFTVI QLVGMLRGIA AGMKYLAEMN YVHRDLAARN ILVNSNLVCK 720
VSDFGLSRYL QDDTSDPTYT SSLGGKIPVR WTAPEAIAYR KFTSASDVWS YGIVMWEVMS 780
FGERPYWDMS NQDVINAIEQ DYRLPPPMDC PAALHQLMLD CWQKDRNSRP RFAEIVNTLD 840
KMIRNPASLK TVATITAVPS QPLLDRSIPD FTAFTTVDDW LSAIKMVQYR DSFLTAGFTS 900
LQLVTQMTSE DLLRIGVTLA GHQKKILNSI HSMRVQMSQS PTAMA 945
Nucleotide Sequence
(FASTA)
TGGGAGGAAG TCAGCGGCTA CGATGAAAAC CTGAACACCA TCCGCACCTA CCAGGTGTGC 60
AATGTCTTTG AGCCCAACCA GAACAACTGG CTCCTCACCA CCTTCATCAA CCGGCGGGGG 120
GCTCATCGCA TCTACACGGA GATGCGCTTC ACTGTGAGAG ACTGCAGCAG CCTCCCCAAC 180
GTCCCAGGCT CCTGCAAGGA GACCTTCAAC TTGTACTACT ATGAGACTGA CTCAGTTATT 240
GCCACCAAGA AGTCGGCCTT CTGGTCTGAG GCCCCCTACC TCAAAGTAGA CACCATTGCT 300
GCGGATGAGA GCTTCTCCCA GGTGGACTTC GGGGGAAGGT TGATGAAGGT CAACACAGAA 360
GTCAGGAGCT TTGGGCCTCT GACTCGGAAC GGTTTTTACC TCGCTTTCCA GGATTATGGG 420
GCCTGCATGT CTCTCCTTTC TGTGCGTGTC TTCTTCAAGA AGTGTCCCAG CATTGTGCAG 480
AATTTTGCGG TATTTCCAGA GACCATGACG GGGGCAGAGA GTACATCTCT GGTGATTGCT 540
CGGGGGACGT GCATCCCCAA CGCAGAGGAA GTAGACGTGC CCATCAAGCT CTACTGCAAT 600
GGGGATGGAG AGTGGATGGT GCCCATTGGG CGCTGCACCT GCAAGCCTGG CTATGAGGCT 660
GAGAACAGTG TGGCCTGCAA GGCCTGCCCC GCCGGGATGT TCAAGGCCAG CCAGGAAGCT 720
GAGGGGTGCT CCCACTGCCC CTCCAACAGC AGATCCCCTT CAGAGGCATC TCCCATCTGT 780
ACCTGTCGGA CCGGCTATTA CCGAGCGGAT TTTGACCCCC CAGAAGTGGC ATGCACTAGT 840
GTTCCATCAG GCCCCCGAAA TGTCATCTCC ATTGTCAATG AGACGTCCAT CATTCTGGAG 900
TGGCATCCGC CCAGGGAGAC GGGCGGGCGG GACGATGTGA CCTACAACAT CATCTGTAGA 960
AAGTGCCGCG CAGATCGTCG GAGCTGCTCC CGCTGTGACG ACAACGTGGA GTTTGTGCCC 1020
AGGCAGCTGG GCCTGACCGA GTGCCGAGTC TCCATCAGCA GCCTGTGGGC CCACACCCCT 1080
TACACATTCG ACATCCAGGC CGTCAACGGA GTCTCCAGCA AGAGCCCCTT CCCCCCACAG 1140
CATGTCTCCG TCAACATCAC CACAAACCAA GCTGCCCCTT CCACTGTTCC CATCATGCAC 1200
CAGGTCAGCG CCACCATGAA GAGCATCACC TTGTCCTGGC CACAGCCGGA GCAGCCCAAT 1260
GGTATCATCC TGGACTATGA GATCCGGTAC TATGAGAAGG AGCACAATGA GTTCAACTCC 1320
TCCATGGCCA GGAGCCAGAC CAACACGGCA CGGATCGATG GCCTACGGCC CGGCATGGTG 1380
TACGTGGTAC AAGTGCGTGC CCGCACGGTG GCCGGCTATG GCAAGTTCAG CGGCAAGATG 1440
TGCTTCCAGA CGCTGACGGA TGAAAGCTCT CAGCTGAGGG AAACTGAAAC TCTACCCTCA 1500
GTCTTTAAAC TTGGTGTCTA TGGACTAAAA TTTCTCCTCA CCAACATACA GTGTAAAGTC 1560
CTATGTCAAA ATAACTCCTT TTCTAGGGCA AGAGGACAGA GCACTGAGAT GACAGAACAG 1620
GAGAGCACTC TGGGCCACAC AAGCTCCCCA GGGATGAAGA TCTACATTGA CCCCTTCACT 1680
TATGAGGACC CCAACGAAGC TGTCCGGGAG TTTGCCAAGG AGATTGATGT ATCTTTTGTG 1740
AAAATTGAAG AGGTCATCGG AGCAGGGGAG TTCGGAGAGG TGTACAAGGG GCGCCTGAAA 1800
CTTCCGGGCA AGAGGGAAAT CTATGTGGCC ATCAAGACGC TGAAGGCCGG GTACTCGGAG 1860
AAGCAGCGTC GGGACTTTCT GAGCGAGGCC AGCATCATGG GCCAGTTTGA CCATCCCAAC 1920
ATCATCCGCC TGGAAGGCGT GGTCACCAAG AGTCGGCCCG TCATGATCAT CACGGAGTTC 1980
ATGGAGAACG GGGCTTTGGA TTCTTTCCTC AGGCAAAATG ACGGACAGTT CACGGTGATC 2040
CAGCTGGTGG GGATGCTCAG GGGTATTGCC GCAGGCATGA AGTACCTGGC CGAGATGAAC 2100
TATGTGCATC GGGACCTGGC TGCTAGGAAC ATCCTGGTCA ACAGTAACCT GGTGTGCAAG 2160
GTGTCTGACT TTGGCCTTTC CCGCTACCTC CAGGATGACA CCTCAGACCC TACCTACACC 2220
AGCTCCTTGG GAGGGAAGAT CCCCGTGAGA TGGACAGCTC CAGAGGCCAT TGCCTACCGC 2280
AAGTTCACGT CTGCCAGCGA TGTCTGGAGC TACGGGATTG TCATGTGGGA AGTCATGTCA 2340
TTTGGAGAGA GACCCTATTG GGATATGTCC AACCAAGATG TCATCAATGC CATTGAGCAG 2400
GACTACCGGC TGCCCCCACC CATGGACTGT CCAGCTGCCC TACACCAGCT CATGCTGGAC 2460
TGTTGGCAGA AGGACCGTAA CAGCCGGCCC CGCTTTGCAG AGATTGTCAA CACCCTGGAC 2520
AAGATGATCC GAAACCCGGC AAGTCTCAAG ACTGTGGCAA CCATCACCGC CGTGCCTTCC 2580
CAGCCCCTGC TAGACCGCTC CATTCCAGAC TTCACGGCCT TTACCACCGT GGATGACTGG 2640
CTCAGTGCCA TCAAAATGGT CCAGTACAGG GACAGCTTCC TCACCGCTGG CTTCACCTCC 2700
CTCCAGCTGG TCACCCAGAT GACATCAGAA GACCTCCTGA GAATAGGGGT CACCTTAGCA 2760
GGTCATCAGA AGAAGATCCT GAACAGCATT CATTCTATGA GGGTCCAGAT GAGTCAGTCA 2820
CCAACGGCAA TGGCATGA 2838
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 580   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  639
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+mengaldsflr++dgqftviqlvgmlrGia+gmkyl++m
Q: 640   NIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM  699
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay
Q: 700   NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  759
         *******************************99999*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml
Q: 760   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  819
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f++iv++l
Q: 820   DCWQKDRNSRPRFAEIVNTL  839
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIITE FMENGALDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLAEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRY LQDDTSDPTY TSSLGGKIPV RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240
DCWQKDRNSR PRFAEIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00012
EKS-CAJ-00006
EKS-CAF-00006
EKS-CAP-00013
EKS-DAR-00002
EKS-EQC-00006
EKS-FEC-00003
EKS-GAM-00002
EKS-GAG-00006
EKS-GAA-00007
EKS-GOG-00005
EKS-HOS-00006
EKS-ICT-00005
EKS-LOA-00005
EKS-MAM-00005
EKS-MEG-00005
EKS-MIM-00001
EKS-MOD-00007
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORN-00008
EKS-ORC-00006
EKS-ORL-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-PES-00006
EKS-PEM-00001
EKS-POA-00004
EKS-RAN-00006
EKS-SAH-00004
EKS-SUS-00004
EKS-TAG-00013
EKS-TAR-00007
EKS-TEN-00005
EKS-XET-00003
EKS-XIM-00006
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0001525; P:angiogenesis
GO:0048593; P:camera-type eye morphogenesis
GO:0031589; P:cell-substrate adhesion
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0021631; P:optic nerve morphogenesis
GO:0051965; P:positive regulation of synapse assembly
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013