EKS-AIM-00375
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00375
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR583.91.3E-175609942334
StatusUnreviewed
Ensembl ProteinENSAMEP00000002502
UniProt AccessionG1L6I7;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000002354ENSAMEP00000002502ENSAMET00000002610
OrganismAiluropoda melanoleuca
Functional Description
Protein Length992
Protein Sequence
(FASTA)
KAESKDAGFL FFTVVFSAMM FETITNQDLP VIKCVLISHK NNDSSLGISS SYPMASEPPE 60
DLGCALKPES TQAVYGAATV EVDMLASITL QVLVNTPGNI SCLWVFKHSS LNCQPHFDLQ 120
NRGVVSMVIL KMTETQAGEY LLFIQSEATN YTILFTVSIR STLLYTLRRP YFRKMENQDA 180
LVCISESIPE PTVEWVFCDS QSESCKGESP AVVTKEESVL RELFGTDIRC CARNELGREC 240
TKLFTIDLNQ TPQTTPPQLF LKVGEPLWIR CKAVHVNHGF GLSWELENKA LEEGSYFEMS 300
TYSTNRTMIR ILFAFVSSVG RNDTGYYTCS SSEHPSKSAL VTILEKGFIN ASKSSEDYEI 360
DQYEEFCFSV RFKAYPQIRC TWTFSRKSFP CEQSGLDDGY SISKFCNHKH QPGEYIFHAE 420
NDDAEFTKMF TLNIRRKPQV LAETSASQAS CSSDGYPLPS WTWKKCSDKS SNCTEEITEG 480
IWNIKANRKV FGQWVSSSTL NMSEAMKGFL VKCCAYNSLG TSCETILLNS SGPFPFIQDN 540
ISFYATVGLC LPFIAILTLL ICHKYKKQFR YESQLQMVQV TGSLDNEYFY IDFREYEYDL 600
KWEFPRENLE FGKVLGSGAF GKVMNATAYG ISKTGVSIQV AVKMLKEKAD SSEREALMSE 660
LKMMTHLGNH ENIVNLLGAC TLSGPIYLIF EYCCYGDLLN YLRNKREKFH RTWTEIFKEH 720
NFSFYPTFQS QPNSSMPGSR EVQIHQDLDH ISGFNGNSFQ SEDEIEYENQ KRLEEEEDLN 780
VLTFEDLLCF AYQVAKGMEF LEFKSCVHRD LAARNVLVTH GKVVKICDFG LARDIRNDSN 840
YVVRGNARLP VKWMAPESLF EGIYTIKSDV WSYGILLWEI FSLGVNPYPG IPVDANFYKL 900
IQSGFKMDQP FYATEEIYFI MQSCWAFDSR KRPSFPNLTS FLGCQLADAE EAMYQNMDGH 960
VSDRPSGYQN RRPYSREVDS GLLAPQGHGE DS 992
Nucleotide Sequence
(FASTA)
AAAGCTGAAT CAAAAGATGC AGGATTTTTG TTTTTTACAG TTGTTTTTTC AGCAATGATG 60
TTTGAGACTA TTACAAATCA AGATCTGCCT GTGATCAAGT GTGTTTTAAT CAGTCATAAG 120
AACAATGATT CATCACTGGG GATATCATCA TCGTATCCCA TGGCGTCAGA ACCTCCAGAA 180
GACCTCGGGT GTGCCTTGAA GCCTGAGAGC ACACAGGCAG TCTATGGAGC AGCCACTGTG 240
GAAGTGGACA TGTTGGCATC CATCACACTC CAAGTACTGG TCAACACCCC GGGGAACATT 300
TCCTGTCTCT GGGTCTTTAA ACACAGCTCC CTGAATTGCC AGCCACACTT TGATTTACAG 360
AACAGAGGAG TTGTTTCCAT GGTCATTTTG AAAATGACAG AAACCCAAGC TGGAGAATAC 420
CTACTTTTCA TTCAGAGTGA AGCTACCAAT TACACAATAC TGTTTACAGT GAGTATAAGA 480
AGTACACTGC TTTACACATT AAGGAGACCT TACTTCAGAA AAATGGAAAA TCAGGACGCC 540
CTGGTCTGCA TATCTGAGAG TATTCCAGAA CCGACCGTGG AATGGGTGTT CTGCGATTCA 600
CAGAGTGAAA GCTGTAAAGG GGAGAGTCCC GCTGTTGTTA CAAAGGAGGA AAGCGTGCTT 660
CGTGAGCTGT TTGGAACAGA CATAAGGTGC TGTGCAAGAA ACGAGCTGGG CAGGGAGTGT 720
ACCAAGCTGT TCACAATAGA TCTAAATCAA ACGCCTCAGA CCACACCGCC ACAGTTATTT 780
CTGAAAGTAG GGGAACCCTT GTGGATAAGG TGCAAAGCCG TTCATGTAAA CCACGGATTC 840
GGACTCAGCT GGGAGCTAGA AAATAAAGCC CTGGAAGAGG GCAGCTACTT CGAGATGAGT 900
ACCTATTCCA CAAACAGAAC TATGATACGG ATCCTGTTTG CTTTCGTATC ATCCGTGGGA 960
AGGAACGACA CCGGCTATTA CACCTGTTCC TCCTCAGAGC ATCCCAGTAA ATCAGCTCTG 1020
GTTACCATCC TAGAAAAGGG ATTTATAAAT GCTTCCAAAT CAAGTGAAGA TTATGAGATT 1080
GACCAGTATG AAGAGTTTTG TTTTTCTGTC AGGTTTAAAG CATACCCACA AATCAGATGT 1140
ACATGGACCT TCTCTCGAAA ATCGTTTCCT TGTGAGCAGA GTGGCCTTGA TGATGGGTAC 1200
AGCATATCTA AGTTTTGCAA CCATAAACAC CAGCCAGGAG AATATATATT CCATGCAGAA 1260
AATGATGATG CCGAATTCAC AAAGATGTTC ACGCTGAACA TAAGAAGGAA GCCTCAGGTG 1320
CTAGCCGAGA CGTCAGCAAG TCAGGCTTCA TGTTCCTCTG ACGGCTACCC CTTACCATCT 1380
TGGACCTGGA AGAAGTGTTC AGACAAGTCT TCCAACTGCA CAGAGGAGAT CACAGAAGGA 1440
ATCTGGAATA TAAAGGCTAA CAGAAAAGTG TTCGGCCAGT GGGTATCGAG CAGCACCCTT 1500
AACATGAGTG AGGCCATGAA AGGATTCCTG GTGAAGTGTT GTGCCTACAA TTCCCTTGGC 1560
ACATCTTGTG AAACAATCCT TTTAAACTCG TCAGGGCCCT TCCCTTTCAT CCAAGACAAC 1620
ATCTCCTTCT ATGCAACAGT CGGGCTTTGT CTTCCCTTCA TTGCCATTCT AACCTTGCTA 1680
ATTTGTCACA AGTACAAAAA GCAATTTAGG TATGAGAGCC AGCTGCAAAT GGTACAGGTG 1740
ACTGGCTCTT TGGATAATGA GTACTTCTAC ATTGATTTCA GAGAATATGA ATATGATCTC 1800
AAATGGGAGT TTCCAAGAGA AAATTTAGAA TTTGGAAAAG TACTAGGATC AGGTGCTTTC 1860
GGAAAAGTGA TGAATGCAAC AGCTTATGGA ATTAGTAAAA CAGGAGTCTC GATCCAGGTG 1920
GCAGTCAAAA TGCTGAAAGA AAAGGCAGAC AGTTCTGAAA GAGAGGCTCT CATGTCTGAA 1980
CTCAAAATGA TGACTCACCT GGGAAACCAC GAGAATATCG TGAATCTGCT GGGGGCATGC 2040
ACACTGTCAG GACCAATTTA CTTGATTTTT GAATATTGTT GCTATGGTGA TCTTCTCAAC 2100
TATCTAAGAA ATAAAAGAGA AAAATTTCAC AGGACATGGA CAGAGATTTT CAAGGAACAC 2160
AATTTCAGTT TTTACCCCAC TTTCCAATCA CAACCAAATT CCAGTATGCC TGGTTCAAGA 2220
GAAGTTCAGA TACACCAGGA CTTGGATCAT ATCTCAGGGT TCAATGGGAA TTCATTTCAA 2280
TCCGAAGATG AAATTGAATA TGAAAACCAA AAAAGGCTGG AAGAAGAAGA GGACTTGAAT 2340
GTGCTGACAT TTGAAGACCT TCTTTGCTTT GCCTATCAAG TTGCCAAAGG AATGGAATTT 2400
CTGGAATTTA AGTCGTGTGT TCACAGAGAC CTGGCAGCCA GGAACGTGCT CGTGACCCAC 2460
GGGAAAGTGG TGAAGATTTG CGATTTCGGA CTGGCCCGGG ATATCAGGAA TGACTCCAAC 2520
TATGTTGTCA GGGGCAACGC TCGTCTGCCC GTAAAGTGGA TGGCCCCTGA GAGCTTATTT 2580
GAGGGGATCT ACACCATAAA GAGTGACGTC TGGTCGTATG GAATATTACT CTGGGAAATA 2640
TTCTCGCTTG GTGTCAATCC GTACCCTGGT ATTCCGGTTG ATGCTAATTT CTATAAACTC 2700
ATTCAAAGCG GATTTAAGAT GGATCAGCCG TTTTATGCTA CGGAAGAAAT ATACTTTATA 2760
ATGCAATCCT GCTGGGCTTT TGACTCAAGG AAACGGCCGT CCTTCCCCAA TCTAACTTCA 2820
TTTTTGGGAT GTCAGCTGGC AGACGCCGAA GAAGCGATGT ATCAGAACAT GGATGGCCAC 2880
GTCTCAGACC GTCCTTCCGG CTACCAGAAC AGGCGACCTT ACAGTAGAGA GGTGGATTCC 2940
GGGCTCCTGG CTCCCCAGGG TCATGGCGAA GACTCCTAG 2979
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk+++hlG
Q: 609   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLG  668
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 669   NHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRNKREKFHRTWTEIFKEHNFSFYPT-  727
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d++++s ++ ++++se++ +++++++   +eeed
Q: 728   ------FQSQPNSSMPGSRE-VQIHQDLDHISGFNGNSFQSEDEIEYENQKRL--EEEED  778
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardi++d
Q: 779   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIRND  838
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 839   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  898
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 899   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  942
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTHLG 60
NHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRNKREK FHRTWTEIFK EHNFSFYPTF 120
QSQPNSSMPG SREVQIHQDL DHISGFNGNS FQSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDIRND SNYVVRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013