EKS-AIM-00430
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00430
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK425.01.3E-1279293285
StatusUnreviewed
Ensembl ProteinENSAMEP00000002578
UniProt AccessionG1L6R3;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK12
Gene Synonyms/Alias MAPK12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000002456ENSAMEP00000002578ENSAMET00000002689
OrganismAiluropoda melanoleuca
Functional Description
Protein Length349
Protein Sequence
(FASTA)
TAWEVRAVYQ DLQPVGSGAY GAVCSSGDSR TGAKVAIKKL YRPFQSELFA KRAYRELRLL 60
KHMRHENVIG LLDVFTPDET LDDFTDFYLV MLFMGTDLGK LMKHEKLSED RIQFLVYQML 120
KGLKYIHAAG VIHRDLKPGN LAVNEDCELK ILDFGLARQA DSEMTGYVVT RWYRAPEVIL 180
NWMRYTQTVD VWSAGCIMAE MITGKTLFKG SDHLDQLKEI MKVTGTPPAD FVQRLQSADA 240
KNYMEGLPEL EKKDFASILT NASPLAVNLL EKMLVLDAER RVTAAEALTH PYFESLRDTE 300
DEPKAQKYDE SFDDMDRTLD EWKRVTYKEV LSFKPPLQLG TKVSKETAL 349
Nucleotide Sequence
(FASTA)
ACGGCTTGGG AGGTGCGCGC CGTGTACCAG GACCTGCAGC CCGTGGGCTC CGGCGCCTAC 60
GGCGCGGTGT GCAGCTCGGG TGACAGCCGC ACGGGCGCCA AGGTGGCCAT CAAGAAGCTG 120
TACCGGCCCT TCCAGTCGGA GCTCTTCGCC AAGCGCGCCT ACCGCGAGCT GCGCCTGCTC 180
AAGCACATGC GCCACGAGAA CGTCATCGGG CTGCTGGACG TGTTCACGCC TGATGAAACC 240
CTGGATGATT TCACAGACTT TTACCTGGTG ATGCTGTTCA TGGGGACTGA CCTGGGAAAG 300
CTCATGAAGC ACGAGAAACT GAGCGAGGAC CGAATCCAGT TCCTTGTCTA CCAGATGCTG 360
AAGGGGCTGA AGTACATCCA CGCTGCTGGC GTCATCCACA GGGACCTGAA GCCTGGCAAC 420
CTGGCCGTGA ATGAGGACTG TGAGCTGAAG ATTCTGGACT TCGGCCTGGC GAGGCAGGCA 480
GACAGCGAAA TGACTGGGTA TGTGGTGACC CGGTGGTATC GGGCACCCGA GGTCATCTTG 540
AACTGGATGC GCTACACACA GACAGTGGAC GTCTGGTCAG CGGGCTGCAT CATGGCGGAG 600
ATGATCACGG GGAAGACGCT GTTTAAGGGC AGTGACCACC TGGACCAGCT GAAGGAGATC 660
ATGAAGGTGA CAGGGACGCC TCCCGCTGAC TTTGTGCAGA GGCTGCAGAG TGCGGACGCA 720
AAGAACTACA TGGAGGGCCT CCCCGAGTTG GAGAAGAAGG ATTTTGCCTC CATCCTGACT 780
AATGCAAGCC CTCTGGCTGT GAACCTCCTG GAGAAAATGC TGGTGCTAGA TGCAGAGCGG 840
CGGGTGACGG CGGCCGAGGC GCTGACCCAC CCCTACTTTG AGTCACTGCG CGACACGGAG 900
GACGAGCCCA AGGCCCAGAA GTACGATGAG TCCTTCGATG ATATGGACCG CACGCTGGAC 960
GAGTGGAAAC GTGTCACATA TAAAGAAGTG CTCAGCTTCA AGCCTCCCCT GCAGTTGGGG 1020
ACCAAGGTCT CCAAGGAGAC GGCTCTG 1047
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++l+p+g+Gayg v+s+ d+rt+ +vaikkl rpfq+e  akr++REl+llk+++heN+
Q: 9     YQDLQPVGSGAYGAVCSSGDSRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV  68
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i lldvftp+e+l++++d+Ylv+ +m+tdL k++k++kls+++i++l+yq+l+glky+H+
Q: 69    IGLLDVFTPDETLDDFTDFYLVMLFMGTDLGKLMKHEKLSEDRIQFLVYQMLKGLKYIHA  128
         ************************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a+viHrDlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++l++++
Q: 129   AGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMR  184
         **********************************9....*********************
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         yt++vD+Ws+GCI+aE++tgk+lf+g+d++dql++i++v+gtp ++f+++++s  a+ny+
Q: 185   YTQTVDVWSAGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPADFVQRLQSADAKNYM  244
         ************************************************************
S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         + lp+ +kkdf++++++as+ a++Llek+Lvld+++R++++eaL+hpY+
Q: 245   EGLPELEKKDFASILTNASPLAVNLLEKMLVLDAERRVTAAEALTHPYF  293
         ************************************************6
Domain Sequence
(FASTA)
YQDLQPVGSG AYGAVCSSGD SRTGAKVAIK KLYRPFQSEL FAKRAYRELR LLKHMRHENV 60
IGLLDVFTPD ETLDDFTDFY LVMLFMGTDL GKLMKHEKLS EDRIQFLVYQ MLKGLKYIHA 120
AGVIHRDLKP GNLAVNEDCE LKILDFGLAR QADSEMTGYV VTRWYRAPEV ILNWMRYTQT 180
VDVWSAGCIM AEMITGKTLF KGSDHLDQLK EIMKVTGTPP ADFVQRLQSA DAKNYMEGLP 240
ELEKKDFASI LTNASPLAVN LLEKMLVLDA ERRVTAAEAL THPYF 285
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00447
EKS-BOT-00461
EKS-CAJ-00471
EKS-CAF-00462
EKS-CAP-00495
EKS-DAR-00870
EKS-EQC-00455
EKS-GAM-00269
EKS-GAA-00569
EKS-HOS-00471
EKS-LOA-00477
EKS-MAM-00460
EKS-MEG-00381
EKS-MUM-00492
EKS-MUP-00461
EKS-MYL-00458
EKS-NOL-00419
EKS-ORN-00583
EKS-ORC-00436
EKS-ORL-00532
EKS-OTG-00468
EKS-PAT-00441
EKS-PES-00404
EKS-PEM-00254
EKS-POA-00454
EKS-RAN-00474
EKS-SAH-00439
EKS-TAG-00528
EKS-TAR-00575
EKS-TEN-00575
EKS-TUT-00169
EKS-XET-00611
EKS-XIM-00575
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
GO:0045445; P:myoblast differentiation
GO:0018105; P:peptidyl-serine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008352; MAPK_p38.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR01773; P38MAPKINASE.
Created Date20-Feb-2013