EKS-AIM-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	471.4	5.2E-142	77	327	251

Status

Unreviewed

Ensembl Protein

ENSAMEP00000002724

UniProt Accession

G1L758;

Protein Name

Protein Synonyms/Alias

Gene Name

AURKB

Gene Synonyms/Alias

AURKB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000002580	ENSAMEP00000002724	ENSAMET00000002842

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

344

Protein Sequence
(FASTA)

MAQKENAYPW PYGRQMTQPG LNTLPQRVPR KDPATPSALV LMSRSNAQPT AAPGQKVVEN 60

SSGTPNFSTR SFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH 120

QLRREIEIQA HLQHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSR TFDEQRTATI 180

MEELADALMY CHGKKVIHRD IKPENLLLGL QGELKIADFG WSVHAPSLRR KTMCGTLDYL 240

PPEMIEGRTH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPAGA 300

QDLVSKLLKH SPSERLPLAQ VSAHPWVRAH SRRVLPPSAL QSAP 344

Nucleotide Sequence
(FASTA)

ATGGCGCAGA AGGAGAACGC CTACCCCTGG CCCTACGGCC GGCAGATGAC TCAGCCTGGC 60

CTGAACACCC TGCCCCAGAG AGTCCCCCGG AAGGACCCTG CCACCCCGTC TGCGCTTGTC 120

CTCATGAGCC GCTCCAATGC CCAGCCCACA GCTGCCCCTG GCCAGAAGGT GGTGGAGAAC 180

AGCAGTGGGA CACCCAACTT CTCAACGCGC TCCTTCACCA TCGACGACTT TGAGATCGGG 240

CGTCCTCTGG GCAAAGGCAA GTTTGGAAAC GTGTACTTGG CTCGGGAGAA GAAAAGCCAT 300

TTCATTGTGG CTCTCAAGGT CCTCTTCAAG TCTCAGATAG AAAAGGAGGG CGTGGAGCAC 360

CAGCTGCGGA GGGAGATCGA AATCCAGGCC CATCTGCAGC ACCCCAACAT CCTGCGACTC 420

TACAACTATT TCTACGACCG ACGAAGGATC TACTTGATTC TGGAGTACGC CCCCCGCGGG 480

GAGCTCTACA AGGAGCTGCA GAAGAGCCGC ACTTTCGACG AGCAGCGAAC AGCCACGATC 540

ATGGAGGAGC TGGCCGACGC TCTGATGTAC TGCCACGGGA AGAAGGTCAT TCACAGAGAC 600

ATCAAGCCAG AGAATCTGCT CCTGGGGCTC CAGGGCGAGC TGAAGATCGC GGACTTCGGC 660

TGGTCTGTGC ATGCCCCCTC CCTGAGGAGG AAGACGATGT GCGGCACCTT GGACTACCTG 720

CCCCCAGAAA TGATTGAAGG GCGCACGCAT AACGAGAAGG TGGATCTCTG GTGCATCGGA 780

GTCCTCTGCT ACGAGCTGCT GGTGGGAAAC CCGCCCTTCG AGAGCGCCTC CCACAATGAG 840

ACGTATCGGC GCATCGTCAA GGTGGACCTG AAGTTCCCCG CGTCTGTGCC CGCGGGAGCG 900

CAGGACCTCG TCTCCAAACT GCTCAAGCAC AGCCCCTCAG AGCGGCTGCC CCTGGCCCAG 960

GTCTCCGCGC ACCCGTGGGT GCGAGCCCAC TCCCGGAGGG TGCTGCCGCC CTCCGCCCTT 1020

CAGTCTGCCC CCTGA 1035

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         feiGr+lGkGkfGnvylarekks+fivalkvlfk+q+ekegve+qlrreieiq+hl+hpn

Q: 77    FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLQHPN  136

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrly+yf+d++r+ylileyaprGelykelqks+++deqr+a+++eeladal+y+h kkv

Q: 137   ILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELADALMYCHGKKV  196

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllg++gelk+adfGwsvhaps +rkt+cGtldylppem+egr+++ekvdl

Q: 197   IHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRTHNEKVDL  256

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl  240

         w++GvlcyellvG+ppfes+s++ety+ri+kvdlk+p+sv++ga+dl+skllk+ p+erl

Q: 257   WCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPAGAQDLVSKLLKHSPSERL  316

         ************************************************************

S: 241   tladvlahpwi  251

         +la+v+ahpw+

Q: 317   PLAQVSAHPWV  327

         **********8

Domain Sequence
(FASTA)

FEIGRPLGKG KFGNVYLARE KKSHFIVALK VLFKSQIEKE GVEHQLRREI EIQAHLQHPN 60

ILRLYNYFYD RRRIYLILEY APRGELYKEL QKSRTFDEQR TATIMEELAD ALMYCHGKKV 120

IHRDIKPENL LLGLQGELKI ADFGWSVHAP SLRRKTMCGT LDYLPPEMIE GRTHNEKVDL 180

WCIGVLCYEL LVGNPPFESA SHNETYRRIV KVDLKFPASV PAGAQDLVSK LLKHSPSERL 240

PLAQVSAHPW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0032133	; C:chromosome passenger complex
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0034644	; P:cellular response to UV
GO:0002903	; P:negative regulation of B cell apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0071777	; P:positive regulation of cell cycle cytokinesis
GO:0034501	; P:protein localization to kinetochore
GO:0051256	; P:spindle midzone assembly involved in mitosis

KEGG

aml:100478843

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013