EKS-AIM-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.1	2.0E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSAMEP00000002849

UniProt Accession

G1L7I3;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000002675	ENSAMEP00000002849	ENSAMET00000002970

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

969

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SVLELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRMKPFSE NEARHFMHQI 120

VTGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLTREAKD 240

LIHQLLRRNP ADRLSLSSVL DHPFMSRNST TRSKDLGTVE DSIDSGHATI STAITASSST 300

SVSGSFFDRR RLLIGQPLPN KVTIFPKNKN SSDFSSGDGS SLYTQWGNQE QETSNSGRGR 360

VTQDTEERPH SRYLRRAHSS DRSGTSNSQS RPKTHTMERC HSAEMLSKSK RSGVDESEER 420

YSPTNSNVNI FHFFKEKTSN SSGSFERPDN DQPRSNRLCP GKTPFPFPDQ TSQTEMVQQW 480

FGNLQIKAHL RENTEYNSIN PNGDFQGHPD LQDTSRNAWT DMRAKKSPDG SDNGHSAKQL 540

NTMKYMTAFQ SKPEIIQQES IFGSDPLSEQ SKTRDMEPPL GYQKRTLRGI TSPLTAYRLK 600

PIRQKTKKAV VSILDSEEVC VELLKEHASQ EYVKEVLQIS SDGKMITVFY PNDGRGFPLA 660

DRPPPPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS PKITYFTRYA KCILMENSPD 720

ADFEVWFYDG AKIHKTEDLI QVVEKTGKSY TLKCESEINS LKGEIKMYMD HANEGHRICL 780

ALESIISEEE KKSGSAPFFP VIVGRKPGNT SSPNALSPPT SVDPHYLMTD RASLNKMINS 840

AASPKPAPIP NENRMVTNEG RGFTAAVSGT NLSSSLKDCL PKSAQLLKSV FVKNVGWATQ 900

LTSGAVWVQF NDGSQLVVQA GVSSISYISP NGQTTRYGEN EKLPDYIKQK LQCLSSILLM 960

FSNPAPSFE 969

Nucleotide Sequence
(FASTA)

ATGGCGACTT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCTGGAATGG TGCAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAGTT GAAACATCCT TCCGTCTTGG AGCTGTATAA CTATTTTGAA 240

GATAGCAATT ATGTGTATCT AGTATTAGAA ATGTGCCATA ATGGAGAAAT GAACAGGTAT 300

CTAAAGAACA GAATGAAACC ATTCTCAGAA AACGAAGCTC GACACTTTAT GCACCAGATC 360

GTCACAGGAA TGTTGTATCT CCATTCTCAT GGTATATTAC ACCGGGACCT CACACTTTCT 420

AACCTCTTAC TTACCCGTAA TATGAACATC AAGATTGCCG ATTTTGGACT GGCAACTCAA 480

TTGAAAATGC CACATGAGAA GCACTATACA TTATGTGGAA CTCCTAATTA CATTTCACCA 540

GAAATTGCAA CTCGAAGTGC ACATGGACTT GAATCTGATG TTTGGTCCTT GGGCTGTATG 600

TTTTATACAT TGCTTATCGG GAGACCACCT TTTGACACTG ACACAGTCAA GAACACATTA 660

AATAAAGTAG TACTGGCAGA TTATGAAATG CCAACTTTTT TGACAAGAGA GGCCAAGGAC 720

CTTATTCACC AGTTACTTCG TAGAAATCCA GCAGATCGTT TAAGTCTGTC TTCAGTATTA 780

GACCATCCTT TTATGTCCCG AAATTCTACA ACAAGAAGTA AAGATTTAGG AACTGTAGAA 840

GATTCAATTG ACAGTGGACA TGCCACAATT TCTACTGCAA TTACGGCTTC TTCTAGTACC 900

AGTGTAAGTG GTAGTTTCTT TGACAGAAGA AGACTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAGTGACTA TATTTCCAAA GAATAAAAAT TCAAGTGATT TTTCTTCAGG AGATGGAAGC 1020

AGTCTTTATA CTCAGTGGGG AAATCAAGAA CAAGAAACCA GTAATAGTGG AAGGGGAAGA 1080

GTGACCCAGG ATACAGAAGA AAGGCCACAT TCTCGATACC TACGTAGAGC CCATTCCTCT 1140

GATAGATCTG GCACTTCTAA TAGTCAGTCT CGACCAAAAA CACATACAAT GGAACGATGT 1200

CACTCAGCAG AAATGCTTTC AAAATCCAAA AGATCAGGAG TAGATGAAAG TGAAGAAAGA 1260

TACTCACCTA CAAACAGCAA TGTCAATATT TTTCATTTCT TTAAAGAAAA GACATCCAAT 1320

AGTTCTGGAT CTTTTGAAAG ACCTGATAAT GATCAACCAC GCTCCAATCG TCTTTGTCCA 1380

GGAAAAACTC CTTTTCCATT TCCAGACCAG ACATCACAGA CTGAAATGGT ACAACAGTGG 1440

TTTGGAAATC TGCAAATAAA GGCTCATTTA AGAGAAAATA CTGAATACAA CAGCATTAAC 1500

CCAAACGGAG ATTTCCAAGG CCATCCAGAT TTGCAGGACA CATCAAGAAA TGCTTGGACT 1560

GATATGCGAG CCAAAAAGAG CCCTGATGGT TCTGATAATG GGCATTCTGC AAAACAGCTG 1620

AATACCATGA AATACATGAC TGCATTTCAA AGTAAACCTG AGATAATTCA ACAAGAATCT 1680

ATTTTTGGCT CAGATCCTCT TTCTGAACAA AGCAAGACTA GGGATATGGA GCCACCATTG 1740

GGTTATCAGA AACGTACATT ACGAGGCATT ACATCTCCTT TGACTGCTTA CAGGTTAAAA 1800

CCGATTAGAC AGAAAACCAA AAAGGCTGTG GTTAGCATAC TTGATTCCGA GGAGGTATGT 1860

GTGGAACTTC TAAAGGAGCA TGCATCTCAA GAATATGTGA AAGAAGTTCT TCAAATATCT 1920

AGTGACGGAA AGATGATCAC TGTTTTCTAT CCTAACGATG GAAGAGGTTT TCCTCTTGCT 1980

GATAGACCAC CACCCCCTAC TGACAACATC AGTAGGTACA GCTTTGACAA TTTACCAGAG 2040

AAGTACTGGC GAAAATATCA ATATGCTTCC AGATTTGTAC AGCTTGTAAG ATCTAAATCA 2100

CCCAAAATAA CTTATTTTAC AAGATATGCT AAATGTATTT TGATGGAGAA TTCCCCTGAT 2160

GCTGATTTTG AGGTTTGGTT TTATGATGGA GCAAAGATAC ACAAAACCGA AGATTTAATT 2220

CAGGTGGTTG AGAAGACTGG GAAATCTTAT ACCTTAAAAT GTGAAAGTGA AATTAATAGC 2280

TTGAAAGGGG AAATAAAAAT GTATATGGAC CATGCAAATG AGGGCCATCG TATTTGCTTA 2340

GCCCTGGAAT CCATAATTTC AGAAGAGGAG AAGAAAAGTG GAAGTGCCCC CTTTTTCCCA 2400

GTAATTGTAG GAAGAAAACC TGGTAATACT AGTTCACCTA ACGCCTTATC ACCTCCTACT 2460

TCTGTGGATC CACACTACCT GATGACAGAT AGAGCATCTT TGAATAAAAT GATAAATAGT 2520

GCTGCTTCTC CAAAACCGGC ACCAATACCT AATGAAAATC GAATGGTTAC AAATGAAGGA 2580

CGTGGCTTTA CGGCTGCAGT TTCTGGAACA AACCTCTCTT CTAGTCTAAA AGATTGTCTT 2640

CCTAAATCAG CACAACTTTT GAAATCTGTT TTTGTGAAAA ATGTTGGTTG GGCTACACAG 2700

TTAACTAGTG GAGCTGTGTG GGTTCAATTC AATGATGGGT CCCAGTTGGT CGTGCAGGCA 2760

GGAGTGTCTT CTATCAGTTA TATATCACCA AATGGTCAAA CAACTAGGTA TGGAGAAAAT 2820

GAAAAATTAC CAGATTACAT CAAACAGAAA TTACAGTGTC TTTCATCCAT CCTTTTGATG 2880

TTTTCTAATC CAGCTCCTAG TTTTGAATAA 2910

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         +++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qiv+g++ylh++

Q: 72    VLELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRmKPFSENEARHFMHQIVTGMLYLHSHG  131

         ********************************99**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ l++eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLTREAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

VLELYNYFED SNYVYLVLEM CHNGEMNRYL KNRMKPFSEN EARHFMHQIV TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLTREAKDL IHQLLRRNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication
GO:0060707	; P:trophoblast giant cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013