EKS-AIM-00200
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00200
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2585.53.3E-17628384357
StatusUnreviewed
Ensembl ProteinENSAMEP00000003155
UniProt AccessionG1L8D9;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000003000ENSAMEP00000003155ENSAMET00000003285
OrganismAiluropoda melanoleuca
Functional Description
Protein Length453
Protein Sequence
(FASTA)
QAIFTQKNKL LADPLDTRRW QGFQLEEYLI GQSIGKGCSA AVYEATMPVL PQNLEVVKSI 60
RPLPGGGPDV IPREEEPASQ APAFPLAIKM MWNISAGSSS EAIFSTMSQE LVPASRAALA 120
GEYGAVTYRN RRFKGGPKQL APHPNIIRVF RAFTSSVPLL PGALVDYPDV LPPRLHPEGL 180
GHGRTLFLVM KNYPYTLRQY LRENTPSPRL ATVMVLQLLE AVDHLVQQGV AHRDLKSDNI 240
LLELDADGCP WLVITDFGCC LADERTGLQL PFTSWYVDRG GNGCLMAPEV STACPGPQAV 300
IDYSKADAWA VGALAYEIFG LSNPFYGQGR AHLESRSYQE AQLPALPESV PLEARQLVRS 360
LLQREASKRP SARVAANVLH LSLWGEHTLA LKHLQLDKII SWLLQQSAAT LLADRLTEKS 420
CVETKMKMLF LANLEYEALC QAALLLCFWR AAP 453
Nucleotide Sequence
(FASTA)
CAGGCAATTT TTACCCAGAA AAACAAGCTG CTTGCTGACC CTTTGGACAC CAGACGCTGG 60
CAGGGCTTCC AGCTGGAGGA GTATCTGATA GGGCAATCCA TTGGCAAGGG TTGCAGTGCT 120
GCTGTGTATG AAGCCACCAT GCCTGTGTTG CCCCAGAACC TGGAGGTGGT GAAGAGCATC 180
AGGCCTCTTC CAGGCGGAGG CCCAGATGTC ATTCCACGAG AAGAGGAGCC AGCTTCACAG 240
GCCCCTGCCT TTCCCTTAGC CATCAAGATG ATGTGGAATA TCTCGGCGGG CTCCTCCAGT 300
GAAGCCATCT TCAGCACAAT GAGCCAGGAG TTAGTCCCAG CTAGTCGAGC GGCCTTGGCC 360
GGGGAGTACG GAGCGGTCAC TTACAGAAAC AGAAGATTCA AGGGAGGTCC CAAGCAACTG 420
GCCCCTCATC CCAACATCAT CCGGGTCTTC CGTGCCTTCA CCTCCTCGGT ACCACTGCTG 480
CCAGGGGCCC TGGTCGACTA CCCTGACGTG CTGCCCCCAC GTCTTCACCC TGAAGGCCTG 540
GGCCACGGGC GGACTCTCTT CCTCGTTATG AAGAACTACC CCTATACGCT GCGCCAGTAC 600
CTTCGTGAGA ACACCCCGAG CCCCCGCCTC GCCACTGTGA TGGTCTTGCA GCTGCTGGAG 660
GCGGTGGATC ATCTGGTTCA ACAGGGCGTC GCACACAGAG ACTTAAAATC TGACAATATT 720
CTCTTGGAGT TGGATGCAGA TGGCTGTCCC TGGCTGGTGA TCACCGACTT CGGCTGCTGC 780
CTGGCTGACG AGCGCACCGG CCTGCAGCTG CCTTTTACCA GCTGGTACGT GGATCGGGGC 840
GGAAACGGCT GCCTGATGGC CCCAGAGGTG TCCACCGCCT GCCCTGGCCC CCAGGCGGTG 900
ATCGACTACA GCAAGGCGGA TGCCTGGGCC GTGGGTGCGC TCGCCTATGA GATCTTTGGG 960
CTCTCCAATC CCTTTTATGG CCAGGGCAGG GCCCACCTTG AAAGCCGCAG TTACCAGGAG 1020
GCTCAGCTGC CCGCACTGCC TGAGTCGGTG CCTCTGGAGG CAAGACAGCT GGTGAGGTCA 1080
CTGCTCCAGC GAGAGGCCAG CAAGAGACCA TCTGCCCGAG TAGCTGCTAA CGTACTTCAT 1140
TTAAGCCTCT GGGGTGAACA TACTCTAGCC CTGAAGCACC TACAACTAGA CAAGATAATC 1200
AGCTGGCTCC TCCAGCAGTC AGCTGCCACT CTGTTGGCCG ACAGGCTCAC AGAAAAGAGC 1260
TGCGTGGAAA CCAAGATGAA GATGTTATTT CTAGCCAACC TGGAGTATGA AGCGCTGTGC 1320
CAGGCAGCCC TGCTCCTCTG CTTCTGGAGA GCAGCCCCGT GA 1362
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgll.gkevtvvlaeidqesavaakkfp  59
         ylig+++gkgc+aavyeat++ l+q+le+ k++  l g +++v+ +e+++   + a++fp
Q: 28    YLIGQSIGKGCSAAVYEATMPVLPQNLEVVKSIRPLpGGGPDVIPREEEPA--SQAPAFP  85
         99******************************9877699999999887765..56899**
S: 60    laiklmfnieadssseallksmsqelvpasrvaldgeygav..........pkllakhPn  109
         laik+m+ni+a+sssea++++msqelvpasr+al+geygav          pk+la+hPn
Q: 86    LAIKMMWNISAGSSSEAIFSTMSQELVPASRAALAGEYGAVtyrnrrfkggPKQLAPHPN  145
         ************************************************************
S: 110   ivrvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqd  169
         i+rv+raf++sv+llP+al+dyPd+lp+rl+peglg+g+tl+lvmk+y+ tlr+yl +++
Q: 146   IIRVFRAFTSSVPLLPGALVDYPDVLPPRLHPEGLGHGRTLFLVMKNYPYTLRQYLRENT  205
         ************************************************************
S: 170   rstrlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkv  229
         +s+rla+++++qlleavdhlv++gvahrdlksdnil+eld d++P+lvi+dfGCclad+ 
Q: 206   PSPRLATVMVLQLLEAVDHLVQQGVAHRDLKSDNILLELDADGCPWLVITDFGCCLADER  265
         ************************************************************
S: 230   dglrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPf  289
         +gl+lp++s++vd+GGn++lmaPe+sta pGp+avi+y+kad+WavGalayeifglsnPf
Q: 266   TGLQLPFTSWYVDRGGNGCLMAPEVSTACPGPQAVIDYSKADAWAVGALAYEIFGLSNPF  325
         ************************************************************
S: 290   ygegkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         yg+g+a+les+syqeaqlPalpesvp e+rqlv++ll+reaskr+sa++aanvl+lsl+
Q: 326   YGQGRAHLESRSYQEAQLPALPESVPLEARQLVRSLLQREASKRPSARVAANVLHLSLW  384
         **********************************************************9
Domain Sequence
(FASTA)
YLIGQSIGKG CSAAVYEATM PVLPQNLEVV KSIRPLPGGG PDVIPREEEP ASQAPAFPLA 60
IKMMWNISAG SSSEAIFSTM SQELVPASRA ALAGEYGAVT YRNRRFKGGP KQLAPHPNII 120
RVFRAFTSSV PLLPGALVDY PDVLPPRLHP EGLGHGRTLF LVMKNYPYTL RQYLRENTPS 180
PRLATVMVLQ LLEAVDHLVQ QGVAHRDLKS DNILLELDAD GCPWLVITDF GCCLADERTG 240
LQLPFTSWYV DRGGNGCLMA PEVSTACPGP QAVIDYSKAD AWAVGALAYE IFGLSNPFYG 300
QGRAHLESRS YQEAQLPALP ESVPLEARQL VRSLLQREAS KRPSARVAAN VLHLSLW 357
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013