EKS-AIM-00097

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00097

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	492.7	1.9E-148	342	592	251

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003329

UniProt Accession

G1L8V1;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003081	ENSAMEP00000003329	ENSAMET00000003461
ENSAMEG00000003081	ENSAMEP00000003320	ENSAMET00000003452

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

603

Protein Sequence
(FASTA)

LFLKNRYEIT MLQGRGEKKK YRKGFIDVSK IKCVEIVKND EGVIPCQNKY PFQVVHDANT 60

LYIFAPSAQS RDRWVKKLKE EIKNNNNIMI KYHPKFWADG SYQCCRQTEK LAPGCEKYNL 120

FESSIKKALP PAPETKKRRP PPPIPPEEED NSEEIVVAMY DFQATEAHDL RLERGKEYII 180

LEKNDVHWWR ARDKYGSEGY IPSNYVTGKK SNNLDQYEWY CRNTNRSKAE QLLRTEDKEG 240

GFMVRDSSQP GMYTVSLYTK FGGEGSSGFR HYHIKETTTS PKKYYLAEKH AFGSIPEIIE 300

YHKHNAAGLV TRLRYPVSTK EKNAPTTAGF SYEKWEINPS ELTFMRELGS GLFGVVRLGK 360

WRAQYKVAIK AIREGAMCEE DFIEEAKVMM KLTHPKLVQL YGVCTQQKPI YIVTEFMERG 420

CLLNFLRQRQ GHFSRDVLLS MCQDVCEGME YLERNSFIHR DLAARNCLVN EAGVVKVSDF 480

GMARYVLDDQ YTSSSGAKFP VKWCPPEVFN YSRFSSKSDV WSFGVLMWEI FTEGKMPFEK 540

NTNYEVVTMV TRGHRLYRPK LASKYVYEVM LRCWQEKPEG RPSFEDMLRT IDELVECEET 600

SGR 603

Nucleotide Sequence
(FASTA)

TTATTTCTAA AGAATAGATA TGAGATTACT ATGCTTCAGG GTAGAGGAGA AAAAAAAAAA 60

TACAGAAAGG GATTTATTGA CGTTTCAAAA ATCAAGTGTG TGGAAATAGT GAAGAATGAT 120

GAGGGTGTTA TTCCCTGCCA AAATAAATAT CCATTTCAGG TTGTCCATGA TGCTAACACA 180

CTTTACATTT TTGCACCTAG TGCACAAAGC AGGGACCGGT GGGTGAAGAA GTTAAAAGAA 240

GAAATAAAGA ACAACAATAA TATTATGATT AAATATCATC CTAAATTTTG GGCAGACGGA 300

AGTTATCAGT GTTGCAGACA AACTGAAAAA TTAGCACCTG GATGCGAAAA ATATAACCTT 360

TTTGAGAGTA GTATAAAAAA AGCACTACCT CCAGCACCAG AAACAAAGAA GCGAAGGCCT 420

CCCCCACCAA TTCCACCTGA AGAAGAAGAC AATAGTGAAG AAATCGTTGT AGCCATGTAT 480

GATTTCCAAG CAACAGAGGC ACATGATCTC AGATTAGAGA GAGGCAAAGA GTATATTATA 540

TTAGAAAAGA ATGATGTTCA TTGGTGGAGA GCAAGAGATA AATATGGGAG TGAAGGATAT 600

ATCCCAAGTA ATTATGTAAC AGGAAAGAAA TCAAACAACT TAGACCAATA TGAGTGGTAT 660

TGCAGAAATA CGAATAGAAG CAAAGCAGAA CAGCTCCTCA GAACTGAAGA TAAAGAAGGT 720

GGTTTTATGG TAAGGGATTC CAGTCAACCA GGCATGTATA CGGTCTCCCT TTATACAAAG 780

TTTGGAGGTG AGGGCTCGTC AGGTTTCAGG CATTATCATA TAAAGGAAAC AACAACATCC 840

CCAAAGAAGT ATTATCTGGC AGAAAAACAT GCATTTGGTT CAATTCCTGA AATTATTGAA 900

TATCATAAGC ACAATGCAGC AGGACTTGTC ACAAGACTGC GGTACCCAGT TAGTACGAAG 960

GAGAAGAATG CACCAACCAC TGCAGGATTC AGCTATGAAA AATGGGAGAT CAATCCTTCA 1020

GAGCTGACCT TTATGAGGGA ACTAGGGAGC GGACTGTTTG GAGTGGTGAG GCTCGGCAAG 1080

TGGAGAGCTC AGTACAAAGT GGCAATCAAA GCTATTAGGG AAGGTGCCAT GTGTGAGGAA 1140

GACTTTATAG AAGAAGCTAA AGTGATGATG AAGCTGACAC ACCCGAAGCT GGTACAACTT 1200

TATGGTGTAT GCACCCAGCA GAAACCAATT TACATTGTTA CCGAGTTCAT GGAAAGGGGC 1260

TGTCTTCTGA ATTTCCTCCG ACAGAGACAA GGTCATTTTA GTAGAGATGT GCTGCTGAGC 1320

ATGTGTCAAG ATGTGTGTGA AGGGATGGAG TACCTGGAGA GAAACAGCTT CATTCACAGA 1380

GATCTGGCTG CCAGAAATTG TCTAGTAAAT GAGGCGGGAG TTGTGAAAGT ATCAGATTTT 1440

GGAATGGCCA GGTACGTTCT GGACGATCAG TACACAAGTT CCTCTGGTGC AAAATTTCCA 1500

GTGAAGTGGT GTCCGCCCGA GGTGTTTAAT TACAGTCGCT TTAGTAGCAA ATCGGATGTC 1560

TGGTCATTTG GTGTTTTAAT GTGGGAAATA TTCACTGAAG GCAAAATGCC TTTTGAGAAA 1620

AACACCAACT ATGAAGTGGT AACCATGGTT ACCCGGGGCC ACCGACTCTA TAGGCCGAAG 1680

TTGGCGTCCA AATATGTATA CGAGGTGATG CTGAGATGTT GGCAGGAGAA ACCAGAGGGA 1740

AGGCCTTCCT TTGAAGATAT GCTGCGCACA ATAGATGAAC TAGTCGAGTG TGAAGAAACT 1800

TCTGGAAGAT AA 1812

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam+eedfieeakvmmkl+hpklvqly

Q: 342   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY  401

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr++++++++++ll+mc+dvcegmeyler+sfihrd

Q: 402   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD  461

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e+ vvkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 462   LAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  521

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwe+f+egk+p+ek++n+evv++v+rg+rlyrpklask+vyevm +cw+ekpe+r

Q: 522   SFGVLMWEIFTEGKMPFEKNTNYEVVTMVTRGHRLYRPKLASKYVYEVMLRCWQEKPEGR  581

         ************************************************************

S: 241   ptfkellsale  251

         p+f+++l+++

Q: 582   PSFEDMLRTID  592

         ********995

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HFSRDVLLSM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVNE AGVVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEIF TEGKMPFEKN TNYEVVTMVT RGHRLYRPKL ASKYVYEVML RCWQEKPEGR 240

PSFEDMLRTI D 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

aml:100463806

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013