EPS-AIM-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	236.8	3.5E-70	94	344	251

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003249

UniProt Accession

G1L8N0;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003084	ENSAMEP00000003249	ENSAMET00000003380

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLV RSGGSHVRRR VLLSSRLLQD DKRLTPTCHT STTEPRCSRF DPDGSGRPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASH IGKRKENEDR FVSAQLTDEV 120

LYFAVYDGHG GPAAADFCHT HMEKCIMDLL PKEKNLETVL TLAFLEIDKA FAKHAHLSAD 180

ATLLTSGTTA TVALVRDGIE LVVASVGDSR AILCRKGKPM KLTIDHTPER KDEKTRIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPS EAAHAVIEQA IQYGSEDNST AVVVPFGAWG KYKNSEINFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCCACAG CTGCCTTAAT TACTTTGGTT AGAAGTGGTG GGAGCCACGT GAGAAGGAGA 60

GTGCTGCTGA GCTCCCGCCT ACTGCAGGAC GACAAGCGGC TGACACCCAC CTGCCACACC 120

TCCACTACTG AGCCTAGGTG TTCTCGGTTT GACCCGGATG GCAGCGGGCG TCCAGCCACC 180

TGGGACAATT TTGGGATCTG GGATAACCGC ATCGATGAGC CCATTCTGCT GCCGCCCAGC 240

ATTAAGTATG GCAAGCCAAT TCCCAAAATC AGTCTGGAAA ACGTAGGCTG TGCCTCGCAC 300

ATTGGCAAAC GAAAAGAGAA TGAAGACCGG TTTGTCAGCG CTCAGCTAAC GGATGAGGTC 360

CTGTACTTTG CCGTGTATGA CGGGCACGGC GGACCTGCAG CTGCTGATTT CTGTCACACT 420

CACATGGAGA AATGCATCAT GGATTTGCTT CCTAAGGAGA AGAATTTGGA AACTGTGTTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCC TTTGCAAAGC ACGCCCACCT GTCTGCTGAT 540

GCAACCCTTC TGACCTCTGG GACTACTGCA ACAGTAGCCC TGGTGAGAGA TGGTATTGAA 600

CTGGTTGTAG CCAGTGTTGG GGATAGCCGG GCTATTTTGT GTAGAAAAGG AAAACCCATG 660

AAGCTGACCA TTGACCATAC TCCAGAAAGA AAAGATGAAA AAACCAGGAT CAAGAAATGT 720

GGTGGTTTTG TAGCTTGGAA TAGTTTGGGA CAGCCTCACG TGAATGGCAG ACTTGCAATG 780

ACAAGGAGTC TTGGAGATTT GGATCTTAAA ACCAGTGGTG TGATAGCAGA ACCAGAAACA 840

AAGAGGATTA AGCTGCATCA TGCCGATGAC AGCTTCCTGG TCCTCACTAC GGATGGAATT 900

AACTTCATGG TGAATAGTCA AGAGATCTGT GACTTTGTCA ATCAGTGCCA TGATCCCAGT 960

GAAGCAGCCC ATGCTGTGAT TGAGCAGGCA ATACAGTATG GTAGTGAAGA TAACAGTACT 1020

GCGGTAGTAG TGCCTTTTGG TGCCTGGGGA AAATACAAGA ACTCAGAAAT CAACTTCTCA 1080

TTCAGCAGAA GCTTTGCCTC CAGTGGACGA TGGGCCTGA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s  g+r+e ed++ s    +   + +d++ +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASHIGKRKENEDRFVS----A---QLTDEVLYFAVYDGHGGPAAADFCHTHMEKCI  146

         57899999999999999954....2...2334589*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e++++++l+ aFl++d+++   ++++l+ d+    sG+ta+val++d  +

Q: 147   MDLLP----KEKNLETVLTLAFLEIDKAF--AKHAHLSADAtlltSGTTATVALVRDGiE  200

         ***87....********************..67776677767899*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va vGdSra+Lcr+gk+++l+ dH+p+r+dE+ Ri++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKTRIKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R+lGdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSLGDLDLKtSGVIAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICDFVNQCHD--  318

         **********566************999999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++gs+dn +a+vv

Q: 319   --PSEAAHAVIEQAIQYGSEDNSTAVVV  344

         ..***********************997

Domain Sequence
(FASTA)

NVGCASHIGK RKENEDRFVS AQLTDEVLYF AVYDGHGGPA AADFCHTHME KCIMDLLPKE 60

KNLETVLTLA FLEIDKAFAK HAHLSADATL LTSGTTATVA LVRDGIELVV ASVGDSRAIL 120

CRKGKPMKLT IDHTPERKDE KTRIKKCGGF VAWNSLGQPH VNGRLAMTRS LGDLDLKTSG 180

VIAEPETKRI KLHHADDSFL VLTTDGINFM VNSQEICDFV NQCHDPSEAA HAVIEQAIQY 240

GSEDNSTAVV V 251

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013