EKS-AIM-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	359.4	1.3E-107	20	303	284

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003370

UniProt Accession

G1L901;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003163	ENSAMEP00000003370	ENSAMET00000003505

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

354

Protein Sequence
(FASTA)

LESSFGRQMA VDVKSRAKRY EKLDFLGEGQ FATVYKARDK NTNQIVAIKK IKLGHRSEAK 60

DGINRTALRE IKLLQELSHP NIIGLLDAFG HKSNISLVFD FMETDLEVII KDNSLVLTPS 120

HIKAYMLMTL QGLEYLHQHW ILHRDLKPNN LLLDENGVLK LADFGLAKSF GSPNRAYTHQ 180

VVTRWYRAPE LLFGARMYGV GVDMWAVGCI LAELLLRVPF LPGDSDLDQL TRIFETLGTP 240

TEEQWPDMCS LPDFVTFKSF PGIPLQHIFI AAGDDLLDLI QGLFLFNPCT RITATQALKT 300

KYFSNRPGPT PGCQLPRPNC PLETLKEQSN PAVATKRKRT QALEQGGLPK KLIF 354

Nucleotide Sequence
(FASTA)

TTGGAGTCGA GTTTTGGGCG ACAGATGGCG GTGGACGTGA AGTCGCGAGC AAAGCGTTAT 60

GAAAAACTGG ACTTCCTCGG GGAGGGACAG TTTGCCACGG TTTACAAGGC CAGAGACAAG 120

AACACCAACC AAATTGTCGC CATTAAGAAA ATAAAACTTG GGCATAGATC AGAAGCTAAG 180

GATGGTATAA ATAGAACAGC CTTAAGAGAA ATAAAATTAT TACAGGAGCT AAGTCATCCA 240

AATATAATTG GTCTCCTTGA TGCTTTTGGA CATAAATCTA ATATTAGTCT TGTGTTTGAT 300

TTTATGGAAA CTGATCTGGA GGTTATAATA AAGGATAATA GTCTTGTGCT GACACCATCA 360

CATATCAAAG CCTACATGTT GATGACTCTT CAAGGGTTAG AATATTTACA TCAACATTGG 420

ATTCTACATA GGGATCTAAA ACCAAACAAC TTGTTGCTAG ATGAAAATGG AGTTCTAAAA 480

TTGGCAGATT TTGGCCTGGC CAAATCATTT GGGAGCCCCA ATAGAGCTTA TACACATCAG 540

GTTGTAACCA GGTGGTATCG GGCCCCCGAG TTACTCTTTG GAGCTAGAAT GTATGGCGTA 600

GGTGTGGACA TGTGGGCTGT TGGCTGTATA TTAGCAGAGC TGCTTCTAAG GGTTCCTTTT 660

TTGCCAGGAG ATTCAGACCT TGATCAACTA ACAAGAATAT TTGAAACTTT GGGCACACCA 720

ACTGAGGAAC AGTGGCCTGA CATGTGTAGT CTTCCAGATT TCGTGACATT TAAGAGTTTT 780

CCTGGAATCC CGTTACAACA CATCTTCATT GCAGCAGGAG ACGACTTGCT AGATCTCATA 840

CAAGGCTTAT TCTTATTTAA CCCATGTACT CGAATTACAG CGACACAGGC ATTGAAAACT 900

AAGTATTTCA GTAATCGGCC AGGGCCAACA CCTGGATGTC AGCTGCCAAG ACCAAACTGT 960

CCACTGGAAA CTTTAAAGGA GCAGTCAAAT CCAGCTGTAG CAACAAAACG GAAGAGAACA 1020

CAGGCCTTGG AACAAGGAGG ATTACCCAAG AAGCTAATTT TTTAG 1065

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 20    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  79

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 80    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  137

         ***********.99**********************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 138   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  197

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp++  +

Q: 198   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDFV-T  256

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ + ++ ++ ldl++ l+ ++p +Ri+a++al++kyf

Q: 257   FKSFPGIPLQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYF  303

         9999999******99999****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDFVTFKS 240

FPGIPLQHIF IAAGDDLLDL IQGLFLFNPC TRITATQALK TKYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013