EKS-AIM-00100
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00100
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec481.84.1E-145271521251
StatusUnreviewed
Ensembl ProteinENSAMEP00000003365
UniProt AccessionG1L8Z6;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000003170ENSAMEP00000003365ENSAMET00000003500
OrganismAiluropoda melanoleuca
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MICFSDNTIQ SIFCCCCCCS LQKRQVRTQI SLSKDEEFSE KYPQRRRLWS RELPSKKQSN 60
RDHVQPSKRK PLPPLPPSEV TEEKIQVKAL YDFLPREPCD LALKRSEEYL ILEKYNPHWW 120
KARDRLGNEG LIPSNYVTEN KLTNLEIYEW YHRNITRNQA ERILRQESKE GAFIVRDSRH 180
LGSYTISVFI KARRNMEATI KHYQIKKNDS GQWYVAERHL FQSIPDLIWY HQHNAAGLMT 240
RLRYPVGLMG SCLPATAGFS YEKWEIDPAE LAFVKEIGSG QFGVVHLGEW RAHIRVAIKA 300
ISEGSMSEED FIEEAKVMMK LSHSRLVQLY GVCIQQKPLY IVTEFMENGC LLSYLRDRRG 360
SLSREGLLSM CQDVCEGMEY LERNCFIHRD LAARNCLVNA ASIVKISDFG MTRYVLDDEY 420
ISSSGAKFPI KWSPPEVFHF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS 480
QGFRLYRPQL APMSIYEVMY SCWHEKPKGR PTFAELLQVL TEIAETW 527
Nucleotide Sequence
(FASTA)
ATGATCTGCT TTTCAGATAA TACCATCCAG TCGATTTTCT GTTGCTGTTG CTGCTGTTCA 60
TTGCAGAAGC GACAAGTAAG AACACAAATA AGCCTGAGCA AAGATGAAGA ATTTTCAGAA 120
AAATACCCTC AGCGTCGCAG GCTGTGGTCC AGGGAATTGC CAAGCAAGAA GCAATCCAAT 180
AGAGACCACG TGCAACCGTC AAAACGCAAG CCGCTGCCTC CCCTCCCACC CTCTGAGGTT 240
ACCGAAGAGA AGATCCAAGT AAAGGCACTG TATGATTTTC TGCCCAGAGA GCCGTGTGAC 300
TTAGCATTAA AGAGATCAGA GGAATACCTG ATACTGGAGA AGTATAACCC TCACTGGTGG 360
AAGGCAAGAG ACCGTTTGGG GAATGAAGGC TTAATCCCAA GCAACTATGT GACCGAAAAC 420
AAACTAACCA ATTTAGAAAT ATATGAGTGG TACCATAGAA ACATTACCAG AAATCAGGCA 480
GAACGTATTT TGAGACAAGA GTCTAAAGAA GGTGCATTTA TCGTCAGAGA TTCAAGACAT 540
TTGGGATCCT ACACAATTTC TGTGTTTATA AAAGCTAGAA GAAATATGGA GGCTACCATC 600
AAACATTACC AGATTAAAAA GAATGACTCA GGACAGTGGT ACGTGGCTGA AAGACACCTC 660
TTTCAATCAA TCCCTGACTT GATCTGGTAT CACCAGCACA ATGCGGCAGG TCTCATGACC 720
CGTCTCCGCT ACCCCGTTGG ACTGATGGGC AGCTGTTTGC CTGCCACAGC TGGTTTTAGC 780
TATGAAAAGT GGGAGATAGA TCCTGCTGAG TTGGCTTTTG TGAAGGAGAT TGGAAGCGGT 840
CAGTTTGGGG TGGTCCATTT AGGTGAATGG CGAGCCCACA TCCGGGTGGC CATCAAGGCC 900
ATCAGCGAAG GCTCCATGTC CGAAGAGGAT TTCATCGAAG AGGCTAAAGT GATGATGAAG 960
TTGTCTCATT CCAGGCTGGT GCAGCTCTAT GGAGTGTGCA TACAGCAGAA GCCGCTGTAC 1020
ATCGTCACCG AGTTTATGGA GAACGGCTGC TTGCTGAGCT ATCTCCGAGA CAGAAGGGGA 1080
TCACTTTCCA GGGAGGGGCT GCTGAGCATG TGCCAGGATG TCTGTGAAGG GATGGAGTAT 1140
CTGGAGAGGA ACTGCTTCAT TCATAGGGAC TTAGCAGCAA GGAATTGTCT GGTCAATGCT 1200
GCAAGTATAG TAAAAATATC AGACTTCGGA ATGACGAGGT ATGTTTTGGA TGATGAATAT 1260
ATCAGTTCTT CTGGAGCCAA GTTCCCAATC AAGTGGTCCC CTCCTGAAGT TTTCCATTTC 1320
AACAAGTACA GCAGCAAATC TGATGTCTGG TCATTTGGAG TTTTGATGTG GGAAGTTTTC 1380
ACAGAAGGAA AAATGCCGTT TGAAAATAAG TCAAATCTGC AAGTTGTGGA AGCCATTTCT 1440
CAAGGCTTCC GGCTGTACCG TCCTCAGCTG GCGCCCATGT CCATCTACGA AGTCATGTAC 1500
AGCTGCTGGC ATGAGAAACC GAAAGGCCGC CCGACATTTG CTGAACTCCT GCAGGTTCTC 1560
ACAGAGATTG CGGAAACCTG GTGA 1584
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         l+++ke+gsgqfgvv+lg+wra+i+vaikai eg+mseedfieeakvmmklsh++lvqly
Q: 271   LAFVKEIGSGQFGVVHLGEWRAHIRVAIKAISEGSMSEEDFIEEAKVMMKLSHSRLVQLY  330
         68**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+yivte++engcll ylr+++++l++e ll+mc+dvcegmeyler++fihrd
Q: 331   GVCIQQKPLYIVTEFMENGCLLSYLRDRRGSLSREGLLSMCQDVCEGMEYLERNCFIHRD  390
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+ +++vk+sdfg++ryvldd+y+ss+gakfp+kwsppev++++kyssksdvw
Q: 391   LAARNCLVNAASIVKISDFGMTRYVLDDEYISSSGAKFPIKWSPPEVFHFNKYSSKSDVW  450
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e+ksn +vve++s+g+rlyrp+la++++yevm+scw+ekp++r
Q: 451   SFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPQLAPMSIYEVMYSCWHEKPKGR  510
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+ l+
Q: 511   PTFAELLQVLT  521
         *******9986
Domain Sequence
(FASTA)
LAFVKEIGSG QFGVVHLGEW RAHIRVAIKA ISEGSMSEED FIEEAKVMMK LSHSRLVQLY 60
GVCIQQKPLY IVTEFMENGC LLSYLRDRRG SLSREGLLSM CQDVCEGMEY LERNCFIHRD 120
LAARNCLVNA ASIVKISDFG MTRYVLDDEY ISSSGAKFPI KWSPPEVFHF NKYSSKSDVW 180
SFGVLMWEVF TEGKMPFENK SNLQVVEAIS QGFRLYRPQL APMSIYEVMY SCWHEKPKGR 240
PTFAELLQVL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
aml:100464564;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013