EKS-AIM-00236

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00236

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	248.9	4.8E-74	51	313	263

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003415

UniProt Accession

G1L944;

Protein Name

Protein Synonyms/Alias

Gene Name

STK11

Gene Synonyms/Alias

STK11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003233	ENSAMEP00000003415	ENSAMET00000003551

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

443

Protein Sequence
(FASTA)

SRMDVADPQQ MGMFTEGELM SVGMDTFIHR IDSTEVIYQP RRKRAKLIGK YLMGDLLGEG 60

SYGKVKEVLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK NVIQLVDVLY 120

NEEKQKHRTY MVMEYCVCGM QEMLDSVPEK RFPVCQAHGY FCQLVDGLEY LHSQGIVHKD 180

IKPGNLLLTT SGTLKISDLG VAEALHPFAE DDTCRTSQGS PAFQPPEIAN GLDTFSGFKV 240

DIWSAGVTLY NITTGLYPFE GDNIYKLFEN IGKGDYTIPG DCGPPLSDLL RGMLEYEPAR 300

RFSIQQIRQH SWFRKKHPPA EELVPIPPST DCKDRWRGMT VVPYLEDLHG CADDNGEEDL 360

FDIEDDIIYT QDFTVPGQVP EEEAGQNGQS RGPPKVVCMN GTESAQLSTK SKVERRASAA 420

SNPTRKACSA SSKIRRLSAC KQQ 443

Nucleotide Sequence
(FASTA)

TCCAGGATGG ATGTGGCCGA CCCGCAGCAG ATGGGCATGT TTACAGAGGG GGAGCTGATG 60

TCCGTGGGGA TGGACACGTT CATCCACCGC ATCGACTCCA CGGAAGTCAT CTACCAGCCC 120

CGGCGCAAGC GGGCCAAGCT CATCGGCAAG TACTTGATGG GAGACCTGCT GGGGGAGGGG 180

TCCTACGGCA AGGTGAAGGA GGTGCTGGAC TCGGAGACGC TGTGCAGGAG AGCTGTCAAA 240

ATCCTCAAGA AGAAGAAGTT GCGAAGGATC CCCAACGGGG AGGCGAACGT CAAGAAGGAA 300

ATCCAACTTC TGAGGAGATT ACGGCACAAA AATGTCATCC AGCTGGTGGA CGTGTTGTAC 360

AATGAAGAGA AGCAGAAACA CCGCACGTAT ATGGTGATGG AGTACTGCGT GTGCGGCATG 420

CAGGAGATGC TGGACAGCGT GCCAGAGAAG CGCTTCCCCG TGTGCCAGGC CCACGGGTAC 480

TTCTGCCAGC TGGTGGACGG CCTGGAGTAC TTGCACAGCC AGGGCATCGT GCACAAGGAC 540

ATCAAGCCGG GCAACCTGCT GCTTACCACC AGCGGCACGC TCAAGATCTC CGACCTGGGT 600

GTGGCTGAGG CACTGCACCC TTTTGCTGAG GACGATACGT GCCGCACGAG CCAGGGCTCC 660

CCAGCATTCC AGCCTCCTGA GATTGCCAAT GGCCTCGACA CCTTCTCTGG CTTTAAGGTG 720

GACATCTGGT CAGCTGGGGT CACTCTCTAT AACATCACCA CAGGCCTGTA CCCGTTCGAG 780

GGGGACAACA TCTACAAGTT GTTTGAGAAC ATCGGGAAGG GAGACTACAC GATCCCGGGT 840

GACTGCGGCC CCCCGCTCTC GGACTTGCTG AGAGGGATGC TGGAATACGA GCCAGCCAGG 900

AGGTTCTCCA TACAGCAGAT CAGACAACAC AGCTGGTTCC GGAAGAAGCA CCCGCCAGCT 960

GAGGAGCTGG TGCCCATCCC ACCGAGCACA GACTGCAAGG ATCGCTGGCG CGGCATGACG 1020

GTGGTGCCCT ACCTGGAGGA CCTGCACGGC TGTGCTGACG ACAACGGGGA GGAGGACCTG 1080

TTCGATATCG AGGATGACAT CATCTATACT CAGGACTTCA CGGTGCCCGG ACAGGTCCCA 1140

GAGGAGGAGG CTGGTCAGAA CGGGCAGAGC CGGGGCCCAC CCAAAGTGGT GTGCATGAAT 1200

GGCACAGAGT CGGCCCAGCT GAGCACCAAA TCAAAGGTGG AGCGCCGGGC CAGTGCGGCC 1260

TCCAACCCCA CCCGCAAGGC CTGCTCGGCC AGCAGCAAGA TCCGCCGGTT GTCGGCTTGC 1320

AAGCAGCAAT GA 1332

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+

Q: 51    YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHK  110

         778999******************************965334567***************

S: 59    niikllevi....etkkklylvleyasgg..eLfdyieekgrlkekearklfkqlvsavk  112

         n+i+l++v+    ++k+++y+v+ey+  g  e++d +  ++r++  +a+ +f qlv++++

Q: 111   NVIQLVDVLyneeKQKHRTYMVMEYCVCGmqEMLDSV-PEKRFPVCQAHGYFCQLVDGLE  169

         ********97654556779******998888*****6.8899******************

S: 113   YlhskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPell  169

         Ylhs+givH+D+Kp Nlll++++++ki+D+G+a+    f e+++++t++Gsp++++Pe+

Q: 170   YLHSQGIVHKDIKPGNLLLTTSGTLKISDLGVAEalhPFAEDDTCRTSQGSPAFQPPEIA  229

         *********************************966567788******************

S: 170   kg.kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesL  228

         +g ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg+++ip  + + l++L

Q: 230   NGlDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYTIPGDCGPPLSDL  289

         99899*******************************************************

S: 229   lrklLvvdpekRatieeilkhewl  252

         lr +L+ +p++R++i++i++h+w+

Q: 290   LRGMLEYEPARRFSIQQIRQHSWF  313

         ***********************7

Domain Sequence
(FASTA)

YLMGDLLGEG SYGKVKEVLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK 60

NVIQLVDVLY NEEKQKHRTY MVMEYCVCGM QEMLDSVPEK RFPVCQAHGY FCQLVDGLEY 120

LHSQGIVHKD IKPGNLLLTT SGTLKISDLG VAEALHPFAE DDTCRTSQGS PAFQPPEIAN 180

GLDTFSGFKV DIWSAGVTLY NITTGLYPFE GDNIYKLFEN IGKGDYTIPG DCGPPLSDLL 240

RGMLEYEPAR RFSIQQIRQH SWF 263

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0016020	; C:membrane
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0030295	; F:protein kinase activator activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043276	; P:anoikis
GO:0060070	; P:canonical Wnt receptor signaling pathway
GO:0007050	; P:cell cycle arrest
GO:0030010	; P:establishment of cell polarity
GO:0042593	; P:glucose homeostasis
GO:0051645	; P:Golgi localization
GO:0072332	; P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0030308	; P:negative regulation of cell growth
GO:0060770	; P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0050772	; P:positive regulation of axonogenesis
GO:0030511	; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0046777	; P:protein autophosphorylation
GO:0051896	; P:regulation of protein kinase B signaling cascade
GO:0030111	; P:regulation of Wnt receptor signaling pathway
GO:0010212	; P:response to ionizing radiation
GO:0007286	; P:spermatid development
GO:0001894	; P:tissue homeostasis
GO:0001944	; P:vasculature development

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013