EKS-AIM-00281
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00281
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR455.93.6E-137709965257
StatusUnreviewed
Ensembl ProteinENSAMEP00000003549
UniProt AccessionG1L9H7;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000003273ENSAMEP00000003549ENSAMET00000003687
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1339
Protein Sequence
(FASTA)
MRAKAALQVL GFLLNLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYEKCEVVM 60
GNLEVVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120
LNYNTNSSHA LRQLRFTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 180
RSCPPCHEAC KGRCWGPRPE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 240
TDCFACRLFN DSGACVRQCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 300
CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 360
LDFLITGLNG DPWHKIPALD PEKLNVFQTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420
RSLYNRGFSL LIMKNLNITS LGLRSLREIS AGRIYVSANR QLCYHHSLNW TRLLRGPAEE 480
RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGICV THCNFLNGEP 540
REFAHEAECF SCHPECRPME GAATCNGSGS DACAQCAHFR DGPHCVNSCP SGVLGAKGPI 600
YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQTLALISKT HLAVGLTVVV GLAVIFLILG 660
GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL ARIFKETELR KLKVLGSGVF 720
GTVHKGVWIP EGESIKIPVC IKVIEDKSGR QSFQDVTDHM LAIGSLDHAH IVRLLGLCPG 780
SSLQLVTQYL PLGSLLDHVR QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV 840
LLKSPSQVQV ADFGVADLLP PDDKQLLHSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT 900
VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI DENIRPTFKE 960
LANEFTRMAR DPPRYLVIKR ESGPGIPPGA EPPALTNKDL EEVELEPELE LDLDLEAEED 1020
GLATTLGSAL SLPVGTLNRP RGSQSLLSPS SGYMPMNQGN LGETCQESAV CGSGERCPRP 1080
ASLHPVPRGR LASESSEGHV TGSEAELQEK VSMCRSRSRS PRPRGDSAYH SQRHSLLTPV 1140
TPLSPPGLEE EDVNGYVMPD AHLKGTPSSR EGTLSSVGLS SVLGTEEEDE DDEYEYMNRR 1200
RRRSPTRPPR PSSLEELGYE YMDVGSDLSA SLGSTQSCPL NPGPLMPAAG TTPDEDYEYM 1260
NRRHGGGAPG GDYTAMGACP AAEQGYEEMR AFQGPGHHTP HVHCARLKTL RSLEATDSAF 1320
DNPDYWHSRL FPKANAQRT 1339
Nucleotide Sequence
(FASTA)
ATGAGGGCGA AGGCGGCTCT GCAGGTGCTG GGCTTCCTTC TCAACCTGGC CCGGGGCTCC 60
GAGGTGGGCA ACTCCCAGGC AGTGTGTCCT GGGACTCTGA ATGGGCTGAG TGTGACAGGT 120
GATGCCGAGA ACCAGTACCA GACCTTGTAC AAGCTTTACG AGAAGTGCGA GGTGGTGATG 180
GGGAACCTTG AGGTTGTGCT CACAGGACAC AATGCGGACC TCTCCTTCCT GCAGTGGATC 240
CGAGAAGTGA CCGGCTATGT CCTCGTGGCC ATGAATGAGT TCTCTACGCT GCCACTGCCC 300
AACCTCCGGG TGGTGCGGGG GACTCAGGTG TACGATGGGA AGTTTGCCAT CTTTGTCATG 360
TTGAACTATA ACACCAACTC CAGCCATGCT CTGCGCCAGC TCCGTTTTAC TCAGCTCACT 420
GAGATTCTGT CCGGGGGCGT TTATATTGAG AAGAATGATA AACTTTGTCA CATGGACACA 480
ATCGACTGGA GGGACATCGT GAGGGACCGA GATGCCGAGA TAGTGGTGAA GGACAATGGC 540
AGGAGCTGTC CCCCGTGTCA TGAGGCCTGC AAGGGGCGGT GCTGGGGTCC TAGACCAGAA 600
GACTGCCAGA CATTGACCAA GACCATCTGT GCCCCTCAGT GTAACGGTCA CTGCTTTGGG 660
CCCAACCCCA ACCAGTGCTG CCATGATGAG TGTGCGGGAG GCTGCTCAGG CCCTCAGGAC 720
ACAGACTGCT TTGCCTGTCG ACTCTTCAAT GACAGCGGGG CCTGTGTGCG CCAGTGTCCA 780
CAGCCCCTTG TTTACAACAA GCTCACGTTC CAGCTGGAAC CCAATCCCCA CACCAAGTAT 840
CAGTATGGTG GAGTTTGTGT AGCCAGCTGT CCCCATAACT TCGTGGTGGA TCAAACGTCT 900
TGCGTCCGGG CATGTCCTCC TGACAAGATG GAAGTAGATA AAAATGGACT CAAGATGTGT 960
GAACCTTGTG GGGGGCTGTG CCCCAAAGCC TGTGAGGGGA CAGGCTCGGG GAGCCGCTTC 1020
CAGACTGTGG ACTCCAGCAA CATCGATGGA TTTGTGAACT GCACCAAGAT CCTGGGAAAT 1080
CTGGACTTTC TTATCACTGG CCTCAATGGA GACCCCTGGC ACAAGATCCC TGCACTGGAC 1140
CCCGAGAAGC TCAATGTCTT CCAGACAGTA CGAGAGATCA CAGGTTACCT AAACATCCAG 1200
TCTTGGCCTC CCCACATGCA CAACTTCAGT GTCTTTTCCA ACCTGACAAC CATCGGGGGC 1260
AGAAGCCTGT ACAACCGGGG TTTCTCTTTG TTGATCATGA AGAACTTGAA TATAACATCT 1320
TTGGGCCTCC GATCTTTGAG AGAAATTAGT GCTGGGCGTA TCTACGTAAG TGCCAACAGG 1380
CAGCTCTGCT ACCACCATTC TCTGAACTGG ACCAGGCTGC TTCGGGGGCC TGCAGAAGAG 1440
AGACTAGACA TCAAGCATAA TCGGCCCCGC AGAGACTGCG TGGCAGAGGG TAAAGTGTGT 1500
GATCCTCTGT GCTCCTCTGG GGGATGCTGG GGCCCAGGTC CTGGTCAGTG CCTGTCCTGC 1560
CGAAACTACA GCCGAGGAGG TATCTGCGTG ACCCACTGCA ACTTTCTGAA TGGGGAGCCT 1620
CGTGAGTTTG CCCATGAGGC TGAATGCTTC TCCTGCCACC CGGAGTGCCG ACCCATGGAG 1680
GGTGCTGCCA CATGCAATGG CTCGGGCTCT GATGCTTGTG CTCAGTGTGC CCATTTTCGA 1740
GATGGGCCCC ACTGTGTGAA CAGCTGCCCC AGTGGAGTCC TCGGTGCCAA GGGCCCCATC 1800
TACAAGTACC CAGATGCTCA GAATGAATGT CGGCCCTGCC ATGAGAATTG CACCCAGGGG 1860
TGTAAGGGAC CAGAGCTACA AGACTGTTTA GGTCAAACAC TGGCACTGAT CAGCAAAACC 1920
CATCTGGCAG TGGGTTTAAC AGTGGTAGTG GGATTGGCAG TGATTTTCCT GATCCTGGGA 1980
GGCACTTTTC TCTATTGGCG TGGGCGCCGG ATTCAGAATA AGAGGGCTAT GAGGCGGTAC 2040
TTGGAACGGG GTGAGAGCAT AGAGCCTCTG GATCCCAGTG AGAAGGCTAA CAAAGTCTTG 2100
GCCAGAATCT TCAAAGAAAC AGAGCTGAGG AAGCTTAAAG TGCTTGGTTC AGGCGTCTTT 2160
GGAACCGTGC ACAAAGGAGT ATGGATTCCT GAGGGTGAAT CAATCAAGAT TCCAGTCTGC 2220
ATTAAAGTCA TTGAGGACAA GAGTGGACGG CAAAGTTTCC AAGATGTGAC CGATCATATG 2280
CTGGCCATTG GCAGCCTAGA CCATGCCCAC ATTGTACGGC TGCTGGGACT GTGCCCAGGG 2340
TCATCTCTGC AGCTCGTCAC TCAGTACTTG CCTCTGGGTT CCCTGCTGGA TCACGTGAGA 2400
CAACACCGTG GAGCACTGGG GCCCCAGCTG CTCCTCAACT GGGGAGTACA GATTGCTAAG 2460
GGGATGTACT ACCTTGAGGA GCATGGTATG GTGCATAGGA ACCTGGCGGC CCGAAATGTG 2520
CTACTGAAGT CACCCAGTCA GGTTCAGGTG GCAGATTTTG GGGTGGCTGA CCTGCTTCCC 2580
CCCGATGATA AGCAACTACT ACACAGTGAG GCCAAGACTC CAATTAAGTG GATGGCCCTG 2640
GAGAGTATCC ACTTTGGGAA ATACACACAC CAGAGTGACG TCTGGAGTTA CGGAGTGACC 2700
GTTTGGGAAC TGATGACCTT TGGGGCGGAG CCCTATGCTG GACTACGACT GGCTGAAGTA 2760
CCAGACCTGC TAGAGAAGGG GGAGCGATTG GCGCAGCCCC AGATCTGTAC CATTGATGTC 2820
TACATGGTCA TGGTCAAGTG TTGGATGATT GATGAGAACA TTCGTCCAAC CTTTAAAGAA 2880
CTAGCCAATG AGTTCACCAG GATGGCCCGA GACCCACCAC GGTATCTGGT CATAAAGAGA 2940
GAGAGTGGGC CTGGAATCCC CCCTGGGGCA GAGCCCCCTG CTCTGACAAA CAAGGACCTG 3000
GAGGAGGTGG AGCTGGAGCC AGAACTAGAG CTAGACCTGG ACTTGGAGGC AGAGGAGGAC 3060
GGTCTGGCGA CCACACTAGG CTCTGCCCTC AGCCTGCCAG TTGGAACACT TAATCGGCCC 3120
CGTGGGAGCC AGAGCCTTTT AAGCCCATCA TCTGGATATA TGCCTATGAA CCAGGGTAAT 3180
CTTGGGGAGA CTTGCCAGGA GTCTGCAGTT TGTGGGAGCG GTGAGCGGTG CCCTCGTCCA 3240
GCCTCTTTGC ACCCAGTGCC ACGGGGACGC CTGGCATCAG AGTCCTCAGA GGGCCATGTG 3300
ACAGGCTCTG AGGCTGAGCT CCAGGAGAAG GTGTCAATGT GTAGGAGCCG GAGCCGGAGC 3360
CCACGGCCAC GTGGAGACAG TGCCTACCAT TCCCAGCGCC ACAGCCTGCT CACTCCTGTC 3420
ACCCCACTGT CCCCACCAGG GTTAGAGGAA GAGGATGTCA ATGGATATGT CATGCCAGAT 3480
GCACACCTCA AAGGTACTCC CTCCTCCCGG GAAGGCACCC TTTCTTCAGT GGGCCTCAGT 3540
TCTGTCCTGG GTACTGAAGA AGAAGATGAA GACGATGAGT ATGAATACAT GAACCGGAGG 3600
AGAAGGCGCA GTCCAACTCG TCCCCCTAGG CCCAGTTCTC TCGAAGAGCT GGGTTATGAG 3660
TACATGGATG TGGGATCAGA CCTCAGTGCT TCCCTGGGCA GCACACAGAG TTGCCCACTC 3720
AACCCTGGGC CCCTCATGCC CGCTGCTGGC ACAACCCCAG ATGAGGACTA TGAATATATG 3780
AATCGGCGAC ATGGCGGAGG AGCCCCTGGG GGAGATTACA CAGCCATGGG CGCCTGCCCA 3840
GCAGCTGAGC AGGGGTATGA AGAGATGAGA GCTTTCCAGG GGCCTGGACA CCATACCCCC 3900
CACGTCCATT GTGCCCGCCT CAAAACTCTC CGTAGTTTAG AAGCCACTGA CTCTGCTTTT 3960
GATAACCCTG ATTACTGGCA TAGCAGGCTT TTCCCCAAGG CTAATGCTCA GAGAACATAA 4020
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh
Q: 709   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQDVTDHMLAIGSLDH  768
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+
Q: 769   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  828
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 829   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  888
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw
Q: 889   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  948
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 949   MIDENIRPTFKELANEF  965
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQDVTD HMLAIGSLDH 60
AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00291
EKS-BOT-00299
EKS-CAJ-00306
EKS-CAF-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-DRM-00152
EKS-EQC-00291
EKS-FEC-00285
EKS-GAM-00190
EKS-GAA-00372
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORN-00390
EKS-ORC-00282
EKS-ORL-00361
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-SUS-00263
EKS-TAR-00393
EKS-TEN-00390
EKS-TUT-00065
EKS-XET-00373
EKS-XIM-00380
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016328; C:lateral plasma membrane
GO:0005524; F:ATP binding
GO:0030296; F:protein tyrosine kinase activator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0014037; P:Schwann cell differentiation
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
aml:100468735;
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013