EKS-AIM-00432

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00432

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	415.3	1.2E-124	64	359	296

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003739

UniProt Accession

G1LA16;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003514	ENSAMEP00000003739	ENSAMET00000003888

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MSLHLLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDIWSVG CIMGEMVCHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 360

VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 420

VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR 464

Nucleotide Sequence
(FASTA)

ATGAGCCTCC ATTTATTGTA CTACTGCAGT GAACCAACCT TGGATGTGAA AATTGCCTTT 60

TGTCAGGGAT TCGATAAACA AGTGGATGTG TCATATATTG CCAAACATTA CAACATGAGC 120

AAAAGCAAAG TTGACAACCA ATTCTACAGT GTGGAAGTGG GAGACTCAAC CTTCACAGTT 180

CTTAAGCGCT ACCAGAATTT GAAGCCTATT GGCTCTGGGG CTCAGGGAAT AGTTTGTGCT 240

GCGTACGATG CTGTTCTTGA CAGAAATGTG GCCATTAAGA AGCTCAGCAG ACCCTTTCAG 300

AACCAAACGC ATGCCAAGAG AGCTTACCGG GAGCTGGTCC TCATGAAGTG TGTGAACCAT 360

AAAAACATTA TTAGTTTATT AAATGTCTTC ACACCCCAGA AAACATTGGA GGAGTTCCAA 420

GATGTTTACT TAGTAATGGA ACTGATGGAT GCCAACTTGT GTCAGGTGAT TCAGATGGAA 480

TTAGACCACG AGCGAATGTC TTACCTGCTG TACCAAATGT TGTGTGGCAT CAAGCACCTT 540

CACTCTGCTG GAATTATTCA CAGGGATTTA AAACCAAGTA ACATTGTAGT CAAGTCTGAT 600

TGTACATTGA AAATCCTCGA CTTTGGACTG GCCAGGACGG CAGGCACAAG CTTCATGATG 660

ACTCCTTATG TGGTTACACG TTATTATAGA GCCCCCGAGG TTATTCTGGG AATGGGCTAC 720

AAGGAGAACG TGGATATATG GTCTGTGGGA TGCATTATGG GAGAAATGGT TTGCCACAAA 780

ATCCTCTTTC CAGGAAGGGA CTATATTGAC CAGTGGAACA AGGTAATTGA ACAACTAGGA 840

ACACCATGTC CGGAATTCAT GAAGAAATTG CAACCTACAG TAAGAAACTA TGTGGAGAAT 900

CGGCCCAAGT ATGCAGGACT CACCTTCCCC AAGCTCTTTC CAGATTCCCT CTTCCCAGCG 960

GACTCTGAGC ACAATAAACT CAAAGCCAGC CAAGCCAGGG ACTTACTGTC AAAGATGCTA 1020

GTGATTGACC CAGCAAAAAG GATATCAGTG GATGACGCCT TACAGCACCC TTACATCAAT 1080

GTGTGGTACG ACCCTGCCGA AGTGGAAGCG CCTCCACCTC AGATTTATGA CAAACAGTTG 1140

GATGAAAGAG AACACACCAT TGAAGAATGG AAAGAACTTA TCTACAAGGA AGTAATGAAT 1200

TCGGAAGAAA AGACTAAAAA CGGTGTTGTA AAAGGACAAC CTTCTCCTTC AGGTGCAGCA 1260

GTGAACAGCA GTGAGAGTCT CCCTCCGTCT TCGTCTGTCA ACGACATCTC CTCCATGTCC 1320

ACTGACCAGA CCCTGGCATC CGACACTGAC AGCAGCCTGG AAGCCTCAGC AGGACCCCTG 1380

GGTTGTTGCA GGTGA 1395

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++ +k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 240   YKENVDIWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 299   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  358

         *****************************99*****************************

S: 289   l  289

Q: 359   I  359

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVCHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

aml:100477951

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013