EKS-AIM-00056

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00056

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	384.1	3.8E-115	4	265	262

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003740

UniProt Accession

G1LA17;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK1

Gene Synonyms/Alias

CDK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003520	ENSAMEP00000003740	ENSAMET00000003889

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

265

Protein Sequence
(FASTA)

MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 60

PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQFM DSSLVKSYLY QILQGIVFCH 120

SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 180

YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 240

FPKWKPGSLA SHVKNLDENG LDLLS 265

Nucleotide Sequence
(FASTA)

ATGGAAGATT ATACCAAAAT AGAGAAAATT GGAGAAGGTA CCTATGGAGT TGTGTATAAG 60

GGTAGACACA AAACTACAGG TCAAGTGGTA GCCATGAAGA AAATCAGACT AGAAAGTGAA 120

GAGGAAGGGG TTCCTAGTAC TGCAATTCGG GAAATTTCTC TATTAAAAGA ACTTCGTCAT 180

CCAAATATAG TCAGTCTTCA AGATGTGCTT ATGCAAGATT CCAGGTTATA TCTCATCTTT 240

GAATTCCTTT CCATGGATCT CAAGAAATAC TTAGATTCCA TCCCTCCTGG TCAGTTCATG 300

GATTCTTCAC TTGTTAAGAG TTATTTGTAC CAAATCCTAC AAGGGATTGT GTTTTGCCAC 360

TCCAGAAGAG TTCTGCACAG AGACTTAAAA CCTCAAAATC TATTGATTGA TGACAAAGGA 420

ACAATTAAAT TGGCTGATTT TGGCCTTGCC CGAGCTTTTG GAATACCTAT TAGAGTATAC 480

ACACATGAGG TGGTAACACT CTGGTATAGA TCTCCAGAAG TATTGCTGGG GTCAGCTCGC 540

TACTCAACTC CAGTTGACAT TTGGAGTATA GGCACCATAT TTGCAGAATT AGCAACCAAG 600

AAACCACTTT TCCATGGGGA TTCAGAAATC GATCAACTCT TCAGAATTTT CAGAGCTTTG 660

GGCACTCCCA ATAATGAAGT GTGGCCAGAA GTGGAATCTT TACAAGACTA TAAGAATACA 720

TTTCCCAAGT GGAAACCAGG AAGCCTGGCA TCCCATGTTA AAAACTTGGA TGAAAATGGC 780

TTGGATCTGC TCTCG 795

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y+k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+ni

Q: 4     YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v+L++v++ ++++lyL+fefl++dLkk+l++ +    ++++ vks+l+q+l+g+ ++Hs+

Q: 64    VSLQDVLM-QDSRLYLIFEFLSMDLKKYLDSIPPGqFMDSSLVKSYLYQILQGIVFCHSR  122

         ********.99********************98764789999******************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf+ p + yt+evvTlwYr+Pe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vDiWs+g i+ael+t+kplf+g+seidql+rif+ lgtp+++vwpev++l++yk++fp

Q: 183   TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldlle  262

         k+k+ +l+++vk+l+e++ldll+

Q: 243   KWKPGSLASHVKNLDENGLDLLS  265

         ********************995

Domain Sequence
(FASTA)

YTKIEKIGEG TYGVVYKGRH KTTGQVVAMK KIRLESEEEG VPSTAIREIS LLKELRHPNI 60

VSLQDVLMQD SRLYLIFEFL SMDLKKYLDS IPPGQFMDSS LVKSYLYQIL QGIVFCHSRR 120

VLHRDLKPQN LLIDDKGTIK LADFGLARAF GIPIRVYTHE VVTLWYRSPE VLLGSARYST 180

PVDIWSIGTI FAELATKKPL FHGDSEIDQL FRIFRALGTP NNEVWPEVES LQDYKNTFPK 240

WKPGSLASHV KNLDENGLDL LS 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030496	; C:midbody
GO:0005634	; C:nucleus
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007095	; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0034501	; P:protein localization to kinetochore

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013